An Evaluation of Risk Estimation Procedures for Mixtures of Carcinogens

The estimation of health risks from exposure to a mixture of chemical carcinogens is generally based on the combination of information from several available single compound studies. The current practice of directly summing the upper bound risk estimates of individual carcinogenic components as an upper bound on the total risk of a mixture is known to be generally too conservative. Gaylor and Chen (1996, Risk Analysis) proposed a simple procedure to compute an upper bound on the total risk using only the upper confidence limits and central risk estimates of individual carcinogens. The Gaylor-Chen procedure was derived based on an underlying assumption of the normality for the distributions of individual risk estimates. In this paper we evaluated the Gaylor-Chen approach in terms of the coverage probability. The performance of the Gaylor-Chen approach in terms the coverages of the upper confidence limits on the true risks of individual carcinogens. In general, if the coverage probabilities for the individual carcinogens are all approximately equal to the nominal level, then the Gaylor-Chen approach should perform well. However, the Gaylor-Chen approach can be conservative or anti-conservative if some or all individual upper confidence limit estimates are conservative or anti-conservative.     

Bayesian Nonlinear Regression for the Air Pollution Effects on Daily Clinic Visits in Small Areas of Taiwan

We consider the complete clinic visit records and environmental monitoring data at 50 townships and city districts where ambient air monitoring stations of Taiwan Air Quality Monitoring Stations are located. A Bayesian analysis is carried out using regression spline model on principal components obtained from several pollutant covariables. The appropriate model is selected using Bayesian model averaging. A brief account of our results is provided for the elderly patients group.     

Wavelet-based Bayesian nonlinear regression for the air pollution effects on clinic visits in small areas of Taiwan

We revisit the complete clinic visit records and environmental monitoring data at 50 townships and city districts of Taiwan. Extending the earlier analyses, here we consider a Bayesian analysis using Daubechies wavelet. Appropriate model selection is also considered using Bayesian model averaging. Temperature, dew point, and NO₂ and CO of the current day and the previous day are identified as the pollutants in different areas of the island following some spatial pattern.     

A two-phase approach to estimating time-varying parameters in the capital asset pricing model

Following the development of the economy and the diversification of investment, mutual funds are a popular investment tool nowadays. Choosing excellent targets from hundreds of mutual funds has become more and more crucial to investors. The capital asset pricing model (CAPM) has been widely used in the capital cost estimation and performance evaluation of mutual funds. In this study, we propose a new two-phase approach to estimating the time-varying parameters of CAPM. We implemented a simulation study to evaluate the efficiency of the proposed method and compared it with the commonly used state space and rolling regression methods. The results showed that the new method is more efficient in most scenarios. Meanwhile, the proposed approach is very practical and it is unnecessary to judge and adjust the estimating process for different situations. Finally, we applied the proposed method to equity mutual funds in the Taiwan stock market and reported the performances of two funds for demonstration.     

Can the Web-Form WHOQOL-BREF be an Alternative to the Paper-Form?

The purpose of this study was to test whether the web version is an alternative to the paper version of the short version of the World Health Organization Quality of Life assessment (WHOQOL-BREF). Two studies were conducted. Study 1 used crossover self-controlled trials with 80 participants to compare the web and paper versions and to determine the test–retest reliability of the web version. Study 2 used data from 1,016 web participants to analyze the internal consistency and concurrent and construct validity of the web version. The correlations of domain scores between the web and paper versions ranged from 0.71 to 0.85. Dependent t tests showed no significant differences in domain scores between these two versions. The intra-class correlation coefficients (ICC) for test–retest reliability of web version ranged from 0.79 to 0.91. The Cronbach’s α for internal consistency reliability ranged from 0.60 to 0.83. Multiple regression models indicated that the web version has good concurrent validity. Confirmatory factor analysis (CFA) for the second-order hierarchical factor model also supported the construct validity of the web version. The web version of the WHOQOL-BREF can be the alternative to the paper version for health-related quality of life (HR-QOL) evaluation.     

Odds ratio for a single 2 × 2 table with correlated binomials for two margins

While analyzing 2 × 2 contingency tables, the log odds ratio for measuring the strength of association is often approximated by a normal distribution with some variance. We show that the expression of that variance needs to be modified in the presence of correlation between two binomial distributions of the contingency table. In the present paper, we derive a correlation-adjusted variance of the limiting normal distribution of log odds ratio. We also propose a correlation adjusted test based on the standard odds ratio for analyzing matched-pair studies and any other study settings that induce correlated binary outcomes. We demonstrate that our proposed test outperforms the classical McNemar’s test. Simulation studies show the gains in power are especially manifest when sample size is small and strong correlation is present. Two examples of real data sets are used to demonstrate that the proposed method may lead to conclusions significantly different from those reached using McNemar’s test.