Facility Location with Dynamic Distance Functions

Facility location problems have always been studied with theassumption that the edge lengths in the network are static anddo not change over time. The underlying network could be used to model a city street networkfor emergency facility location/hospitals, or an electronic network for locating information centers. In any case, it is clear that due to trafficcongestion the traversal time on links changes with time. Very often, we have estimates as to how the edge lengths change over time, and our objective is to choose a set of locations (vertices) ascenters, such that at every time instant each vertex has a center close to it (clearly, the center close to a vertex may change over time). We also provide approximation algorithms as well as hardness results forthe K-center problem under this model. This is the first comprehensive study regarding approximation algorithmsfor facility location for good time-invariant solutions.     

Spatio-temporal change-point modeling

There is by now a substantial literature on spatio-temporal modeling. However, to date, there exists essentially no literature which addresses the issue of process change from a certain time. In fact, if we look at change points for purely time series data, the customary form is to propose a model involving a mean or level shift. We see little attempting to capture a change in association structure. Part of the concern is how to specify flexible ways to bridge the association across the time point and still ensure that a proper joint distribution has been defined for all of the data. Introducing a spatial component evidently adds further complication. We want to allow for a change-point reflecting change in both temporal and spatial association. In this paper we propose a constructive, flexible model formulation through additive specifications. We also demonstrate how computational concerns benefit from the availability of temporal order. Finally, we illustrate with several simulated datasets to examine the capability of the model to detect different types of structural changes.     

Modeling the Effectiveness of Respiratory Protective Devices in Reducing Influenza Outbreak

Outbreaks of influenza represent an important health concern worldwide. In many cases, vaccines are only partially successful in reducing the infection rate, and respiratory protective devices (RPDs) are used as a complementary countermeasure. In devising a protection strategy against influenza for a given population, estimates of the level of protection afforded by different RPDs is valuable. In this article, a risk assessment model previously developed in general form was used to estimate the effectiveness of different types of protective equipment in reducing the rate of infection in an influenza outbreak. It was found that a 50% compliance in donning the device resulted in a significant (at least 50% prevalence and 20% cumulative incidence) reduction in risk for fitted and unfitted N95 respirators, high‐filtration surgical masks, and both low‐filtration and high‐filtration pediatric masks. An 80% compliance rate essentially eliminated the influenza outbreak. The results of the present study, as well as the application of the model to related influenza scenarios, are potentially useful to public health officials in decisions involving resource allocation or education strategies.     

Nonparametric Bayesian Methods for Benchmark Dose Estimation

The article proposes and investigates the performance of two Bayesian nonparametric estimation procedures in the context of benchmark dose estimation in toxicological animal experiments. The methodology is illustrated using several existing animal dose‐response data sets and is compared with traditional parametric methods available in standard benchmark dose estimation software (BMDS), as well as with a published model‐averaging approach and a frequentist nonparametric approach. These comparisons together with simulation studies suggest that the nonparametric methods provide a lot of flexibility in terms of model fit and can be a very useful tool in benchmark dose estimation studies, especially when standard parametric models fail to fit to the data adequately.     

Disrupting the ‘life-cycle’ of violence in social relations: recommendations for anti-trafficking interventions from an analysis of pathways out of sex work for women in Eastern India

This article argues for the need to change the ways in which anti-human trafficking (AT) non-government organisations (NGOs) and their interventions in India frame and address violence in sex work. The article asserts that AT NGOs need to move beyond their ideological allegiances and infuse their interventions with a better understanding of the lived realities of women who are coerced into sex work. This argument is based on an analysis of women's pathways out of sex work in Eastern India, which include both finding independent routes, and also reliance on AT interventions. The research suggests that AT interventions need to acknowledge the centrality of social relationships in women's lives and experiences of violence. Social relations influence women's entry into sex work, affect their experiences within it, and shape their pathways out of sex work.     

Mumbai after 26/7 Deluge: Issues and Concerns in Urban Planning

There has been euphoria among the government circles recently to develop Mumbai as a world-class city before the 26/7 floods hit the city. The cities like Shanghai or Singapore were often cited as benchmarks for planning and development of Mumbai in the next decade. However, the dream has been shattered by the unprecedented flood of July 26. Lack of urban planning, unprecedented rains and the failure of the early warning system are some of the important factors for the tragedy. It is the time that Mumbai’s planning and developmental discourses can be unshackled from an illusion of Shanghai or Singapore.     

Bayesian Hidden Markov Modeling of Array CGH Data

Genomic alterations have been linked to the development and progression of cancer. The technique of comparative genomic hybridization (CGH) yields data consisting of fluorescence intensity ratios of test and reference DNA samples. The intensity ratios provide information about the number of copies in DNA. Practical issues such as the contamination of tumor cells in tissue specimens and normalization errors necessitate the use of statistics for learning about the genomic alterations from array CGH data. As increasing amounts of array CGH data become available, there is a growing need for automated algorithms for characterizing genomic profiles. Specifically, there is a need for algorithms that can identify gains and losses in the number of copies based on statistical considerations, rather than merely detect trends in the data.We adopt a Bayesian approach, relying on the hidden Markov model to account for the inherent dependence in the intensity ratios. Posterior inferences are made about gains and losses in copy number. Localized amplifications (associated with oncogene mutations) and deletions (associated with mutations of tumor suppressors) are identified using posterior probabilities. Global trends such as extended regions of altered copy number are detected. Because the posterior distribution is analytically intractable, we implement a Metropolis-within-Gibbs algorithm for efficient simulation-based inference. Publicly available data on pancreatic adenocarcinoma, glioblastoma multiforme, and breast cancer are analyzed, and comparisons are made with some widely used algorithms to illustrate the reliability and success of the technique.     

Order-free co-regionalized areal data models with application to multiple-disease mapping

With the ready availability of spatial databases and geographical information system software, statisticians are increasingly encountering multivariate modelling settings featuring associations of more than one type: spatial associations between data locations and associations between the variables within the locations. Although flexible modelling of multivariate point-referenced data has recently been addressed by using a linear model of co-regionalization, existing methods for multivariate areal data typically suffer from unnecessary restrictions on the covariance structure or undesirable dependence on the conditioning order of the variables. We propose a class of Bayesian hierarchical models for multivariate areal data that avoids these restrictions, permitting flexible and order-free modelling of correlations both between variables and across areal units. Our framework encompasses a rich class of multivariate conditionally autoregressive models that are computationally feasible via modern Markov chain Monte Carlo methods. We illustrate the strengths of our approach over existing models by using simulation studies and also offer a real data application involving annual lung, larynx and oesophageal cancer death-rates in Minnesota counties between 1990 and 2000.