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Low dose risk estimation via simultaneous statistical inferences 总被引:2,自引:0,他引:2
Walter W. Piegorsch R. Webster West Wei Pan Ralph L. Kodell 《Journal of the Royal Statistical Society. Series C, Applied statistics》2005,54(1):245-258
Summary. The paper develops and studies simultaneous confidence bounds that are useful for making low dose inferences in quantitative risk analysis. Application is intended for risk assessment studies where human, animal or ecological data are used to set safe low dose levels of a toxic agent, but where study information is limited to high dose levels of the agent. Methods are derived for estimating simultaneous, one-sided, upper confidence limits on risk for end points measured on a continuous scale. From the simultaneous confidence bounds, lower confidence limits on the dose that is associated with a particular risk (often referred to as a bench-mark dose ) are calculated. An important feature of the simultaneous construction is that any inferences that are based on inverting the simultaneous confidence bounds apply automatically to inverse bounds on the bench-mark dose. 相似文献
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We discuss the issue of using benchmark doses for quantifying (excess) risk associated with exposure to environmental hazards. The paradigm of low-dose risk estimation in dose-response modeling is used as the primary application scenario. Emphasis is placed on making simultaneous inferences on benchmark doses when data are in the form of proportions, although the concepts translate easily to other forms of outcome data. 相似文献
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Walter R. Allen 《Sociological Forum》1995,10(4):569-592
Since 1965 hundreds of articles and books have been published about African American families. Nevertheless, our understanding of these families continues to be limited. There is a tendency to gloss over important within-group differences; thus, monolithic, stereotypic and inaccurance portrayals of Black family life are common. This paper sets aside debates of Black family pathology or viability, focusing instead on these families' essential character. The paper seeks to understand Black families on their own terms, locating them in relevant social, historical, political and cultural contexts. Key empirical patterns and trends reveal dramatic changes in Black family geographic location, headship, quality of life and socioeconomic status since 1950.A complex picture is revealed. There has been gradual but steady overall improvement alongside persistent, extreme racial disparties and pronounced class disparities among Black families. The proposed Black Family Socio-Ecological Context model specifies and connects institutional, interpersonal, environmental, temporal and cultural facts that shape the essential character of Black family life in such a way as to produce characteristics simultaneously shared and idiosyncratic. The model also provides an organized, systematic accounting of research and public policy issues relevant to the study of African American families.An early version co-authored with Richard A. English was presented during the National Council on Family Relations Meetings in Portland, Oregon, October 1980. 相似文献
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Spencer G. Niles Walter P. Anderson Gary Goodnough 《The Career development quarterly》1998,46(3):262-275
Responses to the Adult Career Concerns Inventory (ACCI: Super, Thompson, Lindeman, Myers, & Jordaan, 1988) were organized through cluster analysis to identify different ways in which adults use exploratory behavior to cope with career development tasks. Significant differences in life-role salience among the types of adult career explorers identified were also investigated. Findings indicated a variety of ways in which adults use exploratory behavior. However, no significant differences were found in life-role salience among the types of career explorers. The discussion explains how career counselors can interpret their clients' ACCI profiles to select appropriate career interventions. 相似文献
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Scholars still do not fully understand what activates cynicism in citizens. Although many expect that negative campaigning contributes to this, no consistent evidence has been found. This research introduces a new measure of appeals to cynicism that expands the commonly used positive–negative taxonomy of tone in advertising. Through a content analyses of more than 600 political advertisements aired during U.S. Senate elections, we identify the extent to which candidates use cynical appeals and the conditions under which these are used. We find that appeals to cynicism are common, are distinct from negative appeals, and that most often, ad sponsors target opponents with cynical appeals, describing them as selfish, dishonest and incompetent. Cynicism appears to be a central part of American campaign rhetoric, used by all sorts of candidates, regardless of party, in many different situations. The prevalence of appeals to cynicism may help explain rising cynicism among the public. 相似文献
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Narat Charupat Richard Deaves Travis Derouin Marcelo Klotzle Peter Miu 《Theory and Decision》2013,75(1):17-41
We find suggestive evidence that emotional balance has an impact on probability weighting incremental to demographic controls. Specifically, low negative affectivity (implying high emotional balance) tends to be a characteristic of those whose probability weighting functions exhibit lower curvature and more neutral elevation. In other words, emotional balance seems to push people in the direction of normative expected utility theory. 相似文献