Sleep disturbance as a clinical sign for severe hypogonadism: efficacy of testosterone replacement therapy on sleep disturbance among hypogonadal men without obstructive sleep apnea

Objective: The present subanalysis of the EARTH study investigates the effects of one year testosterone replacement therapy (TRT) on sleep disturbance among hypogonadal men without obstructive sleep apnea.

Methods: Sleep disturbance was defined as three or more points in question 4 of the aging males symptoms (AMS) questionnaire. All participants completed the AMS scale, International Prostatic Symptoms Score (IPSS), Sexual Health Inventory for Men (SHIM) and Short Form 36 (SF-36) health survey at baseline and after 12?months. Sexual symptoms were also evaluated based on three AMS subscores (Q15, 16 and 17).

Results: We identified 100 patients with sleep disturbance, of whom 48 (24 each in the TRT and control groups) were ultimately included for analysis. All SF-36 categories , AMS scale, IPSS and SHIM score subdomains were significantly worse in patients with sleep disturbance than in those without disturbance. Statistically significant differences in sleep disturbance, erectile symptoms, sexual desire and some domains of the SF-36 were observed between the TRT and control groups after 12?months.

Conclusion: Sleep disturbance may be one of the clinical signs for severe hypogonadism. Moreover, TRT improved sleep conditions, sexual function and quality of life among hypogonadal men with sleep disturbance.     

One-host one-parasitoid system: Population dynamics of a zygaenid mothPryeria sinica Moore in an undisturbed habitat

Summary The population dynamics ofPryeria sinica was investigated in an undisturbed area in 1976–1979. We analyzed the process stabilizing the local population by the life table approach for immature stages and the mark-recapture method for the adult stage. Females usually layed about 130 eggs in an egg-mass. The shape of the survivorship curve was convex and was characterized by a relatively low mortality in the egg and larval stages and by a relatively high mortality in the prepupal and pupal stages. The low mortality in the early stage seemed to be not only due to the peculiar life cycle of this species (larvae develop in early spring when natural enemies are not active) but due to their protective nest-webs, larval warning coloration and repellent smell. The high mortality after cocooning was caused by severe parasitization byAgrothereutes minousubae. The number of adult in the population varied by 2.10-fold, which was less than that of other gregarious moths. The life table data and field observations suggest that adult female dispersal would have acted as a stabilizing factor, andA. minousubae as a conditioning factor on the dynamics of the moth population.     

Characterization of Balanced Fractional 3 m Factorial Designs of Resolution III

We consider a fractional 3 ^m factorial design derived from a simple array (SA), which is a balanced array of full strength, where the non negligible factorial effects are the general mean and the linear and quadratic components of the main effect, and m ≥ 2. In this article, we give a necessary and sufficient condition for an SA to be a balanced fractional 3 ^m factorial design of resolution III. Such a design is characterized by the suffixes of indices of an SA.     

Existence conditions for balanced fractional 3m factorial designs of resolution R({00, 10, 01, 20, 11})

We consider a fractional 3^m factorial design derived from a simple array (SA) such that the non negligible factorial effects are the general mean, the linear and the quadratic components of the main effect, and the linear-by-linear and the linear-by-quadratic components of the two-factor interaction. If these effects are estimable, then a design is said to be of resolution R({00, 10, 01, 20, 11}). In this paper, we give a necessary and sufficient condition for an SA to be a balanced fractional 3^m factorial design of resolution R({00, 10, 01, 20, 11}). Such a design is concretely characterized by the suffixes of the indices of an SA.     

Characterization of information matrices for balanced two-level fractional factorial designs of odd resolution derived from two-symbol simple arrays

We consider a balanced fractional 2^m factorial design of resolution 2?+1 which permits estimation of all factorial effects up through ?-factor interactions under the situation in which all (?+1)-factor and higher order interactions are to be negligible for an integer satisfying [m/2]<lE;?m, where [x] denotes the greatest integer not exceeding x. This paper investigates algebraic structure of the information matrix of such a design derived from a simple array through that of an atomic array. We obtain an explicit expression for the irreducible matrix representation based on the above design and its algebraic properties. The results in this paper will be useful to characterize the designs under consideration.     

Characterizing the Risk of Infection from Mycobacterium tuberculosis in Commercial Passenger Aircraft Using Quantitative Microbial Risk Assessment

Quantitative microbial risk assessment was used to predict the likelihood and spatial organization of Mycobacterium tuberculosis ( Mtb ) transmission in a commercial aircraft. Passenger exposure was predicted via a multizone Markov model in four scenarios: seated or moving infectious passengers and with or without filtration of recirculated cabin air. The traditional exponential ( k  = 1) and a new exponential ( k  = 0.0218) dose-response function were used to compute infection risk. Emission variability was included by Monte Carlo simulation. Infection risks were higher nearer and aft of the source; steady state airborne concentration levels were not attained. Expected incidence was low to moderate, with the central 95% ranging from 10⁻⁶ to 10⁻¹ per 169 passengers in the four scenarios. Emission rates used were low compared to measurements from active TB patients in wards, thus a "superspreader" emitting 44 quanta/h could produce 6.2 cases or more under these scenarios. Use of respiratory protection by the infectious source and/or susceptible passengers reduced infection incidence up to one order of magnitude.