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Several colorectal cancer (CRC) screening models have been developed describing the progression of adenomas to CRC. Currently, there is increasing evidence that serrated lesions can also develop into CRC. It is not clear whether screening tests have the same test characteristics for serrated lesions as for adenomas, but lower sensitivities have been suggested. Models that ignore this type of colorectal lesions may provide overly optimistic predictions of the screen‐induced reduction in CRC incidence. To address this issue, we have developed the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model that includes the adenoma‐carcinoma pathway and the serrated pathway to CRC as well as characteristics of colorectal lesions. The model structure and the calibration procedure are described in detail. Calibration resulted in 19 parameter sets for the adenoma‐carcinoma pathway and 13 for the serrated pathway that match the age‐ and sex‐specific adenoma and serrated lesion prevalence in the COlonoscopy versus COlonography Screening (COCOS) trial, Dutch CRC incidence and mortality rates, and a number of other intermediate outcomes concerning characteristics of colorectal lesions. As an example, we simulated outcomes for a biennial fecal immunochemical test screening program and a hypothetical one‐time colonoscopy screening program. Inclusion of the serrated pathway influenced the predicted effectiveness of screening when serrated lesions are associated with lower screening test sensitivity or when they are not removed. To our knowledge, this is the first model that explicitly includes the serrated pathway and characteristics of colorectal lesions. It is suitable for the evaluation of the (cost)effectiveness of potential screening strategies for CRC.  相似文献   
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This article reviews consumption practices concerning vintage, a fashion style based on used or retro‐style garments. Existing studies connect vintage with authenticity, nostalgia and identity. We explore how the vintage style deploys and comments on consumer culture, bypassing producers by wearing old garments to communicate ‘authentic’ identities. We argue that existing theories on consumption, fashion and subculture cannot fully explain vintage practices. Bypassing the dichotomies and one‐dimensional explanations of these theories, we show that vintage, with its ambivalent relation to both subcultural distinction practices and mainstream consumer culture, serves as a prism through which to examine and understand the complexities and subtleties of 21st century consumption practices.  相似文献   
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To achieve greater sustainability, governments need to continuously adapt their purchasing activities to innovations in the market. Sustainable procurement is a decision-making process in which the decisions of procurers determine if the full potential of sustainable procurement is used. The decisions and thus behaviour of procurers are therefore crucial for the successfulness of sustainable procurement. According to organizational theory, commitment to change could influence this behaviour. Hence, in the study, we examined if commitment to implement sustainable procurement increases sustainable procurement behaviour by Dutch public procurers and what determines this commitment to implement sustainable procurement are. Our study shows first that both affective commitment to implement sustainable procurement and procedural justice increase sustainable procurement behaviour. In addition, the results show that commitment to change acts as a mechanism between fit with vision, ecological sustainability attitude, procedural justice and sustainable procurement behaviour.  相似文献   
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Within the framework of an abstract system we establish the existing relationship between the following two solutions: The absorbing sets solution and the generalized stable sets solution.We are grateful to an anonymous referee for helpful comments. Financial support from the project 9/UPV-00035.321-13699/2001 is grateful acknowledged. Inarra gratefully acknowledges the hospitality of Brown University and the financial support from the Ministerio de Educación, Cultura y Deporte, PR 2003-0287.  相似文献   
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The labelling of disabilities in Indonesian society and legislation has changed over time. More recently, the grassroots has used the term difabel to allude to the conceptualisation of ‘differently able’. The persistence of the grassroots in defending the term difabel, while in the UNCRPD ratification era the elites have turned to using disabilitas, alerts us to the power of labels and the role they play. This article provides a critique of the issue of language and the labelling of people with impairments and how it influences the paradigm of policy and service responses, and thereby the future role of differently able people. Given the background on the evolved disability terminology, this article suggests that difabel should also be adopted into broader English usage (i.e. ‘diffability’). Such a term provides a more positive characterisation of people with impairments and reminds us of the importance of emphasising abilities and acknowledging differences.  相似文献   
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In this essay we identify and discuss some of the challenges currently faced by the Pacific Sociological Association (PSA) related to its governance. The PSA is not unlike other regional associations and faces similar challenges. The rapid growth in membership for the association has repeatedly placed strains on the governance structure, particularly on the office of the Executive Director. The formal organization of governance has not always matched the actual ways in which governing is carried out, almost entirely by volunteers. Although there is growth, there is also significant turnover in members from year to year and this presents a challenge for maintaining an active, vibrant organization. The governing structure of elected committees and officers has not changed with membership growth but the number of standing committees has increased dramatically, spreading the volunteer membership thin. To meet these challenges, we make several suggestions. We argue for the importance of maintaining a stable membership; that the PSA should continue its work to formally define roles and positions including a restructuring of its committees; and an emphasis should be placed on providing an intellectual home for the members of the PSA. We elaborate on these responses to the challenges faced by the PSA and suggest considerations for the association as it moves into the final decade of its first 100 years.  相似文献   
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In this article, we analyse how British tabloid newspapers represent relationships between mature British women and the younger Turkish toyboy lovers they meet (and sometimes look for) on their holiday; a practice that is often considered as the female counterpart to male sex tourism, albeit labelled differently as “romance tourism.” Employing a combination of thematic, lexical, narrative, and visual analysis, we examine how the British tabloids make sense of the contradicting social categories and power relations at play in these encounters, in particular with respect to age, gender, nation, and economic position. We consider these contradictions as typical for the intersectionality of gender identities, and use the tabloid stories about romance tourism as a means to study how such intersectionality becomes manifest in everyday practices. We find that the tabloids construct only one dimension of identity as key to women's lives, that is the one of motherhood and more abstractly of caring for others. In addition, they present women as highly vulnerable to exploitation by foreign, exotic others, who are portrayed either as evil con men or—in the sporadic upbeat, happy-ending story we found—as dependent and passive objects of women's desires.  相似文献   
8.
Qualitative Sociology - Embodied experiences are strongly felt, but hard to communicate or verbalize. This article examines people’s articulation and sense-making of their sexual sensations,...  相似文献   
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Why do some public organizations survive and others do not? The bureaucratic retrenchment efforts since the 1980s showed public administration scholars that the structure of the state has its own demography. Yet studies on the survival of public organizations tested different hypotheses using different methods and definitions. This review article reflects on the consequences of different takes on termination, it compares and reports on the main findings thus far and argues that we should study organizational survival focusing on transitions to build on existing empirical work.  相似文献   
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