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We consider a problem of estimating the minimum effective and peak doses in the presence of covariates. We propose a sequential strategy for subject assignment that includes an adaptive randomization component to balance the allocation to placebo and active doses with respect to covariates. We conclude that either adjusting for covariates in the model or balancing allocation with respect to covariates is required to avoid bias in the target dose estimation. We also compute optimal allocation to estimate the minimum effective and peak doses in discrete dose space using isotonic regression.  相似文献   
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In this study, we take the perspective of the individual manager in order to understand the role of culture in managerial sensemaking on interaction within business relationships. Extant literature has found business-to-business relationships and interaction between managers to be an essential part of conducting business. However, it has mostly ignored the role of culture in the process. This has not accounted for the possibility that managers with different cultural backgrounds may differently make sense about business interactions.  相似文献   
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Trade and environment issues in APEC   总被引:1,自引:0,他引:1  
The central argument of this article is that regional economic integration must be complemented by the creation of regional frameworks for environmental management. Beyond working to expand market access, Asia-Pacific Economic Cooperation Mechanism (APEC) countries must cooperate to create conditions which provide incentives for sustainable resource and ecosystem use. In this way, trade and environmental policies can mutually reinforce each other. In one way or another, it is likely that environmental issues will be on the agenda. The crucial issue is how deep and broad will be the integration of trade and environmental concerns. This article suggests some guiding principles and innovative strategies.  相似文献   
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This study focused on the possible links between parental residential and partnering transitions (a parent's move out of the household, introduction of a new maternal and paternal partner) and the initiation of romantic relationships in adolescence. Using data from a prospective cohort study of Dutch adolescents (the TRacking Adolescents' Individual Lives Survey; N = 1,513), recurrent event discrete‐time models with random effects were estimated, controlling for the initial family structure and quality of family climate. The results demonstrated that when all 3 events were considered, only the initiation of a new romantic relationship by the mother was associated with an increase in the odds of initiating a romantic relationship for the adolescent.  相似文献   
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This work examines what role children play in the re-partnering process in five European countries (Norway, France, Germany, Romania, and the Russian Federation) by addressing the following research questions: (1) To what extent do men and women differ in their re-partnering chances?; (2) Can gender differences in re-partnering be explained by the presence of children?; (3) How do the custodial arrangements and the child’s age affect the re-partnering chances of men and women? We use the partnership and parenthood histories of the participants in the first wave of the Generations and Gender Survey (United Nations, Generations and Gender Programme: Survey Instruments. United Nations, New York/Geneva, 2005) to examine the transition to moving in with a new partner following the dissolution of the first marital union, separately for men and women. The story that emerges is one of similarities in the effects rather than differences. In most countries, men are more likely to re-partner than women. This gender difference can be attributed to the presence of children as our analyses show that childless men and women do not differ in their probability to re-partner. Mothers with resident children are less likely to re-partner than non-mothers and a similar though often non-significant effect of resident children is observed for fathers. In most countries we find that as the child ages, the chances to enter a new union increase. In sum, our study indicates that children are an important factor in re-partnering and a contributor to the documented gender gap in re-partnering, and this holds throughout distinct institutional and cultural settings.  相似文献   
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Aboriginal foster parents were surveyed about their physical needs. Each was asked ‘What do you need physically to be a good foster parent?’ A total of 39 unique responses were made. They were grouped together by participants and the grouping data were analysed using multidimensional scaling and cluster analysis. Five concepts resulted from the analysis. The concepts included physical, financial and emotional resources, supplies and equipment, community, fitness and wellness. Results were compared and contrasted with the fostering literature.  相似文献   
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Aboriginal children are overrepresented in care. Aboriginal foster parents are underrepresented. There is a need to recruit and retain Aboriginal foster parents. In the study, Aboriginal foster parents were asked: “What do you need emotionally to be a good foster parent?” The results were analyzed using multidimensional scaling and cluster analysis, leading to eight concepts, including: awareness, contentment, self‐assurance, appreciation, resolve, space, caring, and commitment to one's values. These results were compared with the existing foster parent literature. Similarities and differences were described.  相似文献   
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