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Background

Although there is consensus among many that exclusion of pregnant women from clinical research should be justified, there is uncertainty as to whether and why pregnant women themselves would be willing to participate even if they were found to be eligible. The objective was to identify the reasons why pregnant women participate in clinical research and thereby to distinguish between facilitators and barriers.

Methods

We conducted a systematic review of articles regarding pregnant women’s reasons for participation in clinical research. We used the PubMed/MEDLINE, EMBASE, PsycINFO and CINAHL databases and retrieved additional articles through manually searching the reference lists. We included all articles that reported on pregnant women’s reasons for participation in clinical research. We accumulated all reasons that were mentioned in the total of articles and collated them to themes, classifying these themes as a facilitator or a barrier.

Results

The search identified thirty articles that met the inclusion criteria. Themes classified as facilitators: aspirational benefits, collateral benefits, direct benefits, third party influence and lack of inconvenience. Themes classified as barriers: inconveniences, risks, randomisation, lack of trust in research enterprise, medical reasons and third party influence.

Conclusions

Pregnant women report mostly altruistic and personal reasons for their willingness to participate in clinical research, while barriers primarily relate to inconveniences. It appears that pregnant women’s described reasoning is similar to the described reasoning of non-pregnant research subjects. Enhancing the facilitators and overcoming the barriers is the next step to increase the evidence-base underlying maternal and foetal health.  相似文献   
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To develop and evaluate the Loneliness Literacy Scale for the assessment of short-term outcomes of a loneliness prevention programme among Dutch elderly persons. Scale development was based on evidence from literature and experiences from local stakeholders and representatives of the target group. The scale was pre-tested among 303 elderly persons aged 65 years and over. Principal component analysis and internal consistency analysis were used to affirm the scale structure, reduce the number of items and assess the reliability of the constructs. Linear regression analysis was conducted to evaluate the association between the literacy constructs and loneliness. The four constructs “motivation”, “self-efficacy”, “perceived social support” and “subjective norm” derived from principal component analysis captured 56 % of the original variance. Cronbach’s coefficient α was above 0.7 for each construct. The constructs “self-efficacy” and “perceived social support” were positively and “subjective norm” was negatively associated with loneliness. To our knowledge this is the first study developing a short-term indicator for loneliness prevention. The indicator contributes to the need of evaluating public health interventions more close to the intervention activities.  相似文献   
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This study aimed to advance insight into inter- and intrapersonal processes that may affect the associations between work-related boredom and employee well-being. We employed a daily perspective to examine (1) the relations between work-related boredom and depressed mood at the end of the workday and at the end of the evening after work; (2) whether these relations were stronger for employees with high work centrality (the importance of work to the individual); and (3) whether the indirect association between work-related boredom and depressed mood in the evening (via depressed mood at the end of the workday) was smaller on days during which employees’ basic psychological needs were satisfied after work. Data were collected by means of a 5-day diary study among 106 employees in various occupations in The Netherlands. The results showed that work-related boredom was positively related to both depressed mood at the end of the workday and depressed mood in the evening, but only for employees with high work centrality. Furthermore, daily need satisfaction after work mitigated the indirect relation between work-related boredom and depressed mood in the evening. Based on these findings it can be concluded that work centrality and need satisfaction should be taken into account in order to understand the association between work-related boredom and employee well-being.  相似文献   
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The aim of this study was to propose a tentative model of employment counseling based on 31 critical incident interviews with supervisors, employment counselors, and unemployed job seekers. The incidents (N= 599) mentioned in the interviews were inductively used to develop a category framework describing behaviors of employment counselors. On the basis of the interviews, categories, and incidents within these categories, the authors proposed a 4‐phase preliminary model of the employment counseling process. Findings suggest that employment counseling is a complex and dynamic process involving several distinct and consecutive steps focused on clients, governmental funding agencies, colleagues, and employers.  相似文献   
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