Optimal crossover designs when carryover effects are proportional to direct effects

Crossover designs are used for a variety of different applications. While these designs have a number of attractive features, they also induce a number of special problems and concerns. One of these is the possible presence of carryover effects. Even with the use of washout periods, which are for many applications widely accepted as an indispensable component, the effect of a treatment from a previous period may not be completely eliminated. A model that has recently received renewed attention in the literature is the model in which first-order carryover effects are assumed to be proportional to direct treatment effects. Under this model, assuming that the constant of proportionality is known, we identify optimal and efficient designs for the direct effects for different values of the constant of proportionality. We also consider the implication of these results for the case that the constant of proportionality is not known.     

Designs with Repeated Measurements on Any Number of Units over Varying Periods

In the usual repeated measurements designs (RMDs), the subjects are all observed for the same number of periods and the optimum RMDs require specified numbers of subjects, usually depending on the number of treatments to be used. In practice, it is sometimes not feasible to meet these requirements. To overcome this problem, alternative designs are suggested where any number of available subjects may be used and they may be observed for different periods. These designs are based on suitable serially balanced sequences which are shown to be optimal. Moreover, besides the usual direct and residual effects, the model considered has an extra term due to the interaction effect between them. The recommended designs are universally optimal in a very general class.     

Model-cum-design-based estimation of the prevalence rate of a disease in a locality using spatial smoothing

In this article, we study the problem of estimating the prevalence rate of a disease in a geographical area, based on data collected from a sample of locations within this area. If there are several locations with zero incidence of the disease, the usual estimators are not suitable and so we develop a new estimator, together with an unbiased estimator of its variance, which may be appropriately used in such situations. An application of this estimator is illustrated with data from a large-scale survey, which was carried out in the city of Kolkata, India, to estimate the prevalence rate of stroke. We show that spatial modelling may be used to smooth the observed data before applying our proposed estimator. Our computations show that this smoothing helps to reduce the coefficient of variation and such a model-cum-design-based procedure is useful for estimating the prevalence rate. This method may of course be used in other similar situations.     

D–optimality of a class of saturated main–effect plans and allied results

This paper applies the theory of unimodular matrices to prove that all saturated main effect plans of an s₁ × s₂ factorial are equivalent from the point of view of D–optimality and are hence all D–optimal. The A– and E–optimal plans in this context have also been derived. An application in sequential experimentation has been considered     

Imperfection Measures and the Production of Poverty: A Case Study of the Use of the Asset Index in Bangladesh

Social Indicators Research - This paper takes as its starting point the analytical distinction between a ‘difference-making’ approach and a ‘production approach’ to poverty,...     

Admissibility in factorial designs

The notion of admissibility in factorial designs has been introduced. It has been shown that factorial designs which are binary and have a C-matrix with property A are admissible.     

Privacy protection measures for randomized response surveys on stigmatizing continuous variables

We consider the situation where sample surveys are to be undertaken on sensitive or stigmatizing issues. For such surveys, direct questioning methods usually lead to non-compliance or incorrect responses and so, the randomized response technique, where the responses are collected through some randomization device, is found to be useful. A majority of the literature on these techniques focus on dichotomous sensitive variables, while some techniques are also available for continuous sensitive variables. In this article, we focus on the extent of privacy protection available in sample surveys to respondents for continuous response variables. We also propose two measures of privacy protection. We demonstrate that the parameters of our randomization scheme can be so chosen as to achieve a pre-assigned level of privacy protection while at the same time yielding efficient estimates. We also show some numerical comparisons.     

Cross-over Designs in the Presence of Higher Order Carry-overs

In cross-over experiments, where different treatments are applied successively to the same experimental unit over a number of time periods, it is often expected that a treatment has a carry-over effect in one or more periods following its period of application. The effect of interaction between the treatments in the successive periods may also affect the response. However, it seems that all systematic studies of the optimality properties of cross-over designs have been done under models where carry-over effects are assumed to persist for only one subsequent period. This paper proposes a model which allows for the possible presence of carry-over effects up to k subsequent periods, together with all the interactions between treatments applied at k + 1 successive periods. This model allows the practitioner to choose k for any experiment according to the requirements of that particular experiment. Under this model, the cross-over designs are studied and the class of optimal designs is obtained. A method of constructing these optimal designs is also given.     

Estimation of a sensitive proportion by Warner’s randomized response data through inverse sampling

It is difficult to obtain trustworthy data on stigmatizing matters like habits of tax evasion, drunken driving, etc., through direct queries. To overcome this difficulty, Warner introduced randomized response techniques to estimate the proportion of people bearing such a stigmatizing or sensitive characteristic in a given community. For simplicity in estimation he restricted to SRSWR and since then, several researchers have extended and applied this technique in various ways. All these results involve sampling with a pre-fixed number of draws. In this paper we employ inverse sampling with equal probabilities with replacement and show certain advantages in estimation using randomized response data by Warner’s device gathered through such a simple inverse sampling scheme.