Nonparametric estimation of waiting time distributions in a Markov model based on current status data

We construct nonparametric estimators of state waiting time distribution functions in a Markov multistate model using current status data. This is a particularly difficult problem since neither the entry nor the exit times of a given state are directly observed. These estimators are obtained, using the Markov property, from estimators of counting processes of state entry and exit times, as well as, the size of “at risk” sets of state entry and transitions out of that state. Consistency of our estimators is established. Finite-sample behavior of our estimators is studied by simulation, in which we show that our estimators based on current status data compare well with those based on complete data. We also illustrate our method using a pubertal development data set obtained from the NHANES III [1997. NHANES III Reference Manuals and Reports (CD-ROM). Analytic and Reporting Guidelines: The Third National Health and Nutrition Examination Survey (1988–94). National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD] study.     

Temporal prediction of future state occupation in a multistate model from high-dimensional baseline covariates via pseudo-value regression

In many complex diseases such as cancer, a patient undergoes various disease stages before reaching a terminal state (say disease free or death). This fits a multistate model framework where a prognosis may be equivalent to predicting the state occupation at a future time t. With the advent of high-throughput genomic and proteomic assays, a clinician may intent to use such high-dimensional covariates in making better prediction of state occupation. In this article, we offer a practical solution to this problem by combining a useful technique, called pseudo-value (PV) regression, with a latent factor or a penalized regression method such as the partial least squares (PLS) or the least absolute shrinkage and selection operator (LASSO), or their variants. We explore the predictive performances of these combinations in various high-dimensional settings via extensive simulation studies. Overall, this strategy works fairly well provided the models are tuned properly. Overall, the PLS turns out to be slightly better than LASSO in most settings investigated by us, for the purpose of temporal prediction of future state occupation. We illustrate the utility of these PV-based high-dimensional regression methods using a lung cancer data set where we use the patients’ baseline gene expression values.     

The effects of internal resources and partnership quality on firm performance: An examination of Indian BPO providers

Firms from developed nations are increasingly resorting to business process outsourcing (BPO) as part of their global sourcing strategy. Although BPO is a growing practice, there has been limited empirical attention in understanding the phenomenon, particularly from the perspective of provider firms that execute important business processes for their overseas clients. In this paper we focus on the resources and capabilities that are utilized by the providers in fulfilling their clients' sourcing needs. Using resource-based view and social exchange as theoretical foundations, we argue that providers' human capital, organizational capital, management capability, and partnership quality are crucial assets that are deemed valuable by the clients and are utilized by the providers in attaining higher performance. Using a sample of Indian BPO providers, we empirically test three models (direct, mediating and moderating) to understand how these assets impact firm-level performance. Results show that resources and capabilities relate to performance in varying measures and partnership quality has partial-mediating and moderating effects on these relationships. We conclude by discussing the theoretical and practical implications of the study and highlighting avenues of future inquiry.     

Does Outsourcing Really Improve Firm Performance? Empirical Evidence and Research Agenda

The phenomenon of outsourcing has spawned a rich body of scholarly work in the last two decades. Yet, the answer to one important question has remained elusive: Does outsourcing really improve firm performance? Addressing this question is important as firms across nations continue to embark on the practice of outsourcing to save operating costs and remain competitive. Scholars, practitioners and policy‐makers need to understand whether and how outsourcing benefits the firm. However, no comprehensive review of empirical evidence has been published so far that can address this question. This study reviews 57 empirical research articles that investigated the outsourcing–firm performance relationship in 47 peer‐reviewed scholarly journals over a 20‐year time‐span (1996–2015). The articles differ widely in research scope, context, level of analysis, data source, time‐span, industry sector, extent of outsourcing and measure of performance. The findings suggest that outsourcing can produce positive, negative, mixed, moderated or no significant impact on the firm. This study also provides useful directions for future research on outsourcing and firm performance.     

FPT algorithms for Connected Feedback Vertex Set

We study the recently introduced Connected Feedback Vertex Set (CFVS) problem from the view-point of parameterized algorithms. CFVS is the connected variant of the classical Feedback Vertex Set problem and is defined as follows: given a graph G=(V,E) and an integer k, decide whether there exists F?V, |F|??k, such that G[V?F] is a forest and G[F] is connected. We show that Connected Feedback Vertex Set can be solved in time O(2 ^O(k) n ^O(1)) on general graphs and in time $O(2^{O(\sqrt{k}\log k)}n^{O(1)})$ on graphs excluding a fixed graph H as a minor. Our result on general undirected graphs uses, as a subroutine, a parameterized algorithm for Group Steiner Tree, a well studied variant of Steiner Tree. We find the algorithm for Group Steiner Tree of independent interest and believe that it could be useful for obtaining parameterized algorithms for other connectivity problems.     

First-order random coefficient integer-valued autoregressive processes

A first-order random coefficient integer-valued autoregressive (RCINAR(1)) model is introduced. Ergodicity of the process is established. Moments and autocovariance functions are obtained. Conditional least squares and quasi-likelihood estimators of the model parameters are derived and their asymptotic properties are established. The performance of these estimators is compared with the maximum likelihood estimator via simulation.     

Testing equality of survival distributions when the population marks are missing

This paper introduces a nonparametric approach for testing the equality of two or more survival distributions based on right censored failure times with missing population marks for the censored observations. The standard log-rank test is not applicable here because the population membership information is not available for the right censored individuals. We propose to use the imputed population marks for the censored observations leading to fractional at-risk sets that can be used in a two sample censored data log-rank test. We demonstrate with a simple example that there could be a gain in power by imputing population marks (the proposed method) for the right censored individuals compared to simply removing them (which also would maintain the right size). Performance of the imputed log-rank tests obtained this way is studied through simulation. We also obtain an asymptotic linear representation of our test statistic. Our testing methodology is illustrated using a real data set.     

Analyzing clustered count data with a cluster-specific random effect zero-inflated Conway–Maxwell–Poisson distribution

Count data analysis techniques have been developed in biological and medical research areas. In particular, zero-inflated versions of parametric count distributions have been used to model excessive zeros that are often present in these assays. The most common count distributions for analyzing such data are Poisson and negative binomial. However, a Poisson distribution can only handle equidispersed data and a negative binomial distribution can only cope with overdispersion. However, a Conway–Maxwell–Poisson (CMP) distribution [4] can handle a wide range of dispersion. We show, with an illustrative data set on next-generation sequencing of maize hybrids, that both underdispersion and overdispersion can be present in genomic data. Furthermore, the maize data set consists of clustered observations and, therefore, we develop inference procedures for a zero-inflated CMP regression that incorporates a cluster-specific random effect term. Unlike the Gaussian models, the underlying likelihood is computationally challenging. We use a numerical approximation via a Gaussian quadrature to circumvent this issue. A test for checking zero-inflation has also been developed in our setting. Finite sample properties of our estimators and test have been investigated by extensive simulations. Finally, the statistical methodology has been applied to analyze the maize data mentioned before.