Analysis of microtubule dynamics using growth curve models

Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics.     

Intra-ethnic fissures in ethnic movements: the rise of Mohajir identity politics in post-1971 Pakistan

The article charts the rise of Mohajir identity politics in Pakistan since 1971. Most accounts of Mohajir identity politics have focused mainly on one actor, that is, the Mohajir (now Muttahida) Qaumi Movement and their politics and secondly, have remained silent on intra-ethnic fissures within the Mohajir community. The present article builds on and criticises such accounts for their partiality and presents a more nuanced understanding of politics within the Mohajir community. On the theoretical plane, it criticises modernist and primordialist accounts of ethnicity and nationalism, both of which portray a homogenous picture of ethnic groups as based on unity and shared aims. It is shown that unity and shared aims are at best, a chimera, and that intra-ethnic fissure is as important to understand as is inter-ethnic conflict when it comes to analysing ethnic movements.     

Priority Topics in the Study of Environmental Risk in Developing Countries: Report on a Workshop Held at the East–West Center, August, 1988

The rapid industrialization occurring in developing regions of the world brings not only economic benefits, but changes in the types and severity of health and environmental problems that each region experiences. As the industrialized world moves toward the use of risk assessment methodologies to aid in problem evaluation and regulatory and policy decision analysis, it seems inevitable that these methodologies will be applied globally. The changes brought about by rapid industrialization, however, must be viewed within the context of societies that are still struggling with the more traditional and basic environmental problems associated with urban and rural poverty. The urgency of development and the lack of adequate resources for characterizing health and environmental changes, often present under these circumstances, offer special challenges to the application of risk assessment methodologies.     

A Child Labour Estimator: A Case of Bahawalpur Division

Social Indicators Research - Child labor is a distressing issue. There have been many attempts to estimate its magnitude. It is attempted here to develop an estimator to assess the magnitude of...     

A cross-country comparison of alcohol,tobacco, and marijuana use among youth who are employed,in school or out of the labor force and school (OLFS)

Labor force and school attachment may influence alcohol, tobacco, and marijuana use in the US and Canada. Differences in social welfare provision, which provide protections for individuals with insecure attachments to the labor force or education, may in turn impact the behavior and health of youth in these countries. Yet, there is little research to understand the health consequences for youth of being out of the labor force and school (OLFS). Data of 25–29 year old participants of the National Longitudinal Survey of Youth (year 2010) and the Canadian Community Health Survey (2009–2010) were used to examine differences in substance use by labor force and school attachment. Logistic regression suggests that OLFS in the US and Canada were less likely to report alcohol uptake and more likely to use tobacco compared to employed youth. Unemployment was differentially associated with substance use behaviors by country. Country of residence and subsequent exposure to social welfare policy does not appear to impact substance use behaviors among OLFS. However, associations of unemployment and gender by country indicates differences in substance use behavior. More research should seek to understand factors that influence alcohol, tobacco, and marijuana use among OLFS and unemployed youth.     

The welfare state as a context for children's development: a study of the effects of unemployment and unemployment protection on reading literacy scores

Data were analysed from the Organization for Economic Cooperation and Development (OECD) Program for International Student Assessment (PISA) to examine whether the relationship between parental unemployment status and child reading literacy is modified by the level of unemployment protection provided by the nation. The sample consisted of 61,946 children, nested in 3,918 schools among 17 market economies. The results of multi-level analyses indicated that, after controlling for a range of individual, family and school covariates, children with unemployed fathers in all countries had significantly lower reading literacy scores than those of employed fathers (β = −8.84, SE = 2.01). The contextual effect of unemployment protection was not significant after accounting for fathers' employment status (β = −18.63, SE = 16.26). However, there was a significant negative interaction between unemployment protection and fathers' unemployment, yielding the unexpected suggestion that, in countries with higher levels of unemployment protection, children with unemployed fathers fare worse, both in relation to children with unemployed fathers in lower protection countries, and in comparison with children with employed fathers (β = −26.96, SE = 8.08). Possible explanations are advanced for this result, including the potential for a 'discouraged child effect' arising from the potential association between unemployment protection and higher local unemployment rates (though unemployment rates at the national level were not significant).     

The relevance of thinking-by-analogy for investors’ willingness-to-pay: An experimental study

People tend to think by analogies. We investigate whether thinking-by-analogy matters for investors’ willingness-to-pay for a risky asset in a laboratory experiment. We find that thinking-by-analogy has a strong influence when the assets in question have similar (but not identical) payoffs. The hypothesis of thinking-by-analogy or coarse thinking clearly outperforms other hypotheses including the hypothesis of arbitrage-free or rational pricing. When the similarity between the payoffs is reduced, the risk neutral and risk averse hypotheses outperform the hypothesis of thinking-by-analogy. Regardless of the similarity between the payoffs, the arbitrage-free or rational pricing remains the hypothesis with the worst performance.