Significance of the Dermal Route of Exposure to Risk Assessment

The skin is a route of exposure that needs to be considered when conducting a risk assessment. It is necessary to identify the potential for dermal penetration by a chemical as well as to determine the overall importance of the dermal route of exposure as compared with inhalation or oral routes of exposure. The physical state of the chemical, vapor or liquid, the concentration, neat or dilute, and the vehicle, lipid or aqueous, is also important. Dermal risk is related to the product of the amounts of penetration and toxicity. Toxicity involves local effects on the skin itself and the potential for systemic effects. Dermal penetration is described in large part by the permeability constant. When permeability constants are not known, partition coefficients can be used to estimate a chemical's potential to permeate the skin. With these concepts in mind, a tiered approach is proposed for dermal risk assessment. A key first step is the determination of a skin-to-air or skin-to-medium partition coefficient to estimate a potential for dermal absorption. Building a physiologically-based pharmacokinetic (PBPK) model is another step in the tiered approach and is useful prior to classical in vivo toxicity tests. A PBPK model can be used to determine a permeability constant for a chemical as well as to show the distribution of the chemical systemically. A detailed understanding of species differences in the structure and function of the skin and how they relate to differences in penetration rates is necessary in order to extrapolate animal data from PBPK models to the human. A study is in progress to examine anatomical differences for four species.     

Below the Tip of the Iceberg: Examining Early Childhood Participation in SNAP and TANF from Birth to Age Six

Population Research and Policy Review - In the United States, the SNAP and TANF programs provide financial support to low-income households with children. Yet, little is known about the extent of...     

“Oh,My God,I Hate You:” The Felt Experience of Being Othered for Being Thin

It is universally held among researchers and social critics that a thin ideal dominates current cultural conceptions of what is attractive, especially for women. Using interviews with eighteen women and men, this paper investigates an apparent paradox: how thin people negotiate a landscape where the attention they receive because of their thinness distresses them. Results indicate that thin people are often the target of unwanted comments about their size, comments produce an unpleasant state of self‐consciousness, and the expectation of unwanted social interaction will motivate thin individuals to avoid certain social situations. Results are interpreted in terms of thinness being a hypervisible condition that produces a breakdown of norms regarding civil inattention toward thinness and produces the experience of being othered by social perceivers.     

A first look at the need for enhanced support services for kinship caregivers

This article describes findings from a series of focus groups conducted with formal kinship caregivers in Maryland. The findings reveal that kinship caregivers are committed to providing safety and stability for the children placed with them. The findings also suggest that caregiving can be a significant adjustment for many kinship caregivers and that expanded support services are needed to enhance their relationship with the child welfare agency.