The impact of testosterone replacement therapy on glycemic control,vascular function,and components of the metabolic syndrome in obese hypogonadal men with type 2 diabetes

Objective: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2).

Study design: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n?=?28) was treated with testosterone undecanoate (1000?mg i.m. every 10?weeks) while group P (n?=?27) received placebo.

Methods: Anthropometrical and vascular measurements – flow-mediated dilatation (FMD) and intima media thickness (IMT) – biochemical and hormonal blood sample analyses were performed at the start of the study and after one year. Derived parameters (BMI, HOMA-IR, calculated free testosterone (cFT) and bioavailable testosterone (BT)) were calculated.

Results: TRT resulted in reduction of HOMA-IR by 4.64?±?4.25 (p?p?p?=?.005).

Conclusion: TRT normalized serum testosterone levels, improved glycemic control and endothelial function while exerting no ill effects on the study population.     

Pearson-Tukey Three-Point Approximations Versus Monte Carlo Simulation

Accuracy of the Pearson-Tukey three-point approximation is measured in units of standard deviation and compared with that of Monte Carlo simulation. Using a variety of well-known distributions, comparisons are made for the mean of a random variable and for common functions of one and two random variables. Comparisons are also made for the mean of an assortment of risk-analysis (Monte Carlo) models drawn from the literature. The results suggest that the Pearson-Tukey approximation is a useful alternative to simulation in risk-analysis situations.     

Energy modelling: A new challenge for management science

The Arab oil embargo in 1973 and the subsequent price rises and production restrictions have given birth to a distinct branch within Management Science: energy modelling. This paper gives a critical and selective review on energy modelling, an industry which though thriving in an era of general economic anxiety, is showing signs of arrogant immaturity. After giving a historical background, the paper classifies energy models into three groups: open loop demand or supply models; energy closed loop models; energy-economy closed loop models. For each group the problem area is analysed and some illustrative examples are described. In the last sections, an attempt is made to sum up the experience that has been gained with energy modelling: the basic deficiencies, the impact of this activity on policy formulation and its position within Management Science. It is concluded that energy models, though very poor forecasting devices, can be very useful to policy makers as tools for analysis; energy model developers must convince potential model users and for that purpose they can benefit immensely from the 35-year-long experience accumulated by their colleagues in Management Science.     

Large scale communication networks—Design and analysis

The paper discusses the problem of design and analysis of large scale communication systems. An iterative process, composed of a minimum cost network design algorithm and a network performance algorithm, is presented for the solution of these problems. Computational considerations, using these algorithms, are discussed.     

The use of strategic planning techniques in the United Kingdom

In this paper some of the techniques available for strategic planning are reviewed. Four techniques are presented, the experience curve, the growth-share matrix, the directional policy matrix and the PIMS program. The results of a survey into the use of these techniques in the United Kingdom are also presented.     

Maternal depression,parental attributions,and adolescent psychopathology: An evaluation using observational and video-mediated recall methods

Parenting styles associated with maternal depression are a risk factor for adolescent psychopathology, and maternal attributional styles may be a key mechanism in this relationship. Mother-adolescent dyads (N = 180; 96 male; ages 10–15) completed in-person interactions and then the mothers participated in a video-mediated recall procedure to assess maternal attributions. Maternal depression was associated with negative attributions. Negative attributions were associated with low parental acceptance, aggressive parenting, and low positive parenting. Positive maternal attributions were associated with less aggressive parenting, and more positive parenting during one interaction task. Adolescent externalizing behaviors were associated with negative attributions. Future research should evaluate whether maternal attributions mediate the association between maternal depression and both parenting behaviors and adolescent mental health.     

近四十年来韩国《史记》研究综述（1971—2010）

《史记》是中国史学中一部继往开来的不朽巨著,作者司马迁开创的以人物为中心的纪传体,在汉代以后一直是历代王朝正史所沿用的体制。司马迁修《史记》,不仅尊重历史事实,秉笔直书,而且还注意语言文字的锤炼,文句优美。他将叙事、抒情、说理的不同文体有机地综合起来,达到思想上、艺术上的高度统一,为后代文史创作提供了范例。《史记》不仅是中国纪传体史书的开创者,而且对后世的散文、小说、戏曲都产生了深远的影响。同时它也早已流传至国外,在汉文化圈国家中亦有不小的影响。其中,《史记》传入韩国,特别受到韩国知识界人士的关心和推崇,为韩国学术界所重视。到了1960年代中期,随着国家经济的发展,韩国整个社会的发展进入了一个历史的新时期,不仅国家面貌发生了根本性变化,学术文化事业也步入正轨,同时韩国学术界对中国学术文化的关心及研究也重新得到了高度重视。正是在这样的基础上,韩国学者对《史记》的翻译和研究有了较大的进展,在传播、普及和通俗化方面作出了积极的贡献。本文除简述《史记》在韩国的流传背景外,还分别论述自1971年至2010年近四十年来《史记》在当代韩国的翻译介绍与研究现状,并对其研究成果上存在的一些不足和空缺作一番客观的评价。     

Non‐linear Effects of Comparison Income in Quit Decisions: Status versus Signal!

This research note utilizes German matched employer–employee data to investigate the relationship between mobility and relative wage positions within establishments for workers without university degrees. The main innovation involves the examination of non‐linear effects, because previous literature mainly analyses mean linear effects. Our random‐effects probit estimates of mobility suggest a non‐linear U‐shaped effect with respect to relative standing. This is plausible because workers in low relative wage positions might quit because of their low status and those in high relative wage positions because of their low career advancement opportunities. Consideration of non‐linearities, thus, is a major improvement for the analysis of the effects of relative wage positions.     

Careers and productivity in an internal labor market

This paper contributes to the existing literature by evaluating the effects of age and tenure on careers and productivity within an internal labor market. We use the administrative personnel records of a long balanced panel of blue-collar workers from a manufacturing firm in Germany with a distinct classification of wage groups and unique information on workers’ productivity in form of suggestions for productivity improvement. Using robust locally weighted regression, our main findings suggest that the probability of promotion is highest for younger workers and early in the career. Older workers are less likely to be promoted. The likelihood of making a rewarded suggestion is inversely u-shaped with respect to tenure and age. Furthermore, workers’ ability and firm-specific human capital determine the workers’ careers and productivity.     

The Airline Discount Fare Allocation Problem

This paper describes a useful extension of the well-known, single-period inventory or newsboy problem. Given a fixed number of identical seats available on a scheduled airline flight, what percentage should be offered for early sale at a predetermined discount fare and what percentage reserved for later sale at a higher full fare? This two-tiered pricing strategy with early discount pricing might be appropriate in any situation in which the price sensitivity of the inventoried items decreases as the end of the period approaches. Similar to the newsboy problem solution, the decision rule that maximizes expected profit is expressed as a simple function of the percentage difference in the two fares and two carefully defined probabilities.