Exposure Reconstruction for the TCDD-Exposed NIOSH Cohort Using a Concentration- and Age-Dependent Model of Elimination

Recent studies demonstrating a concentration dependence of elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suggest that previous estimates of exposure for occupationally exposed cohorts may have underestimated actual exposure, resulting in a potential overestimate of the carcinogenic potency of TCDD in humans based on the mortality data for these cohorts. Using a database on U.S. chemical manufacturing workers potentially exposed to TCDD compiled by the National Institute for Occupational Safety and Health (NIOSH), we evaluated the impact of using a concentration- and age-dependent elimination model (CADM) (Aylward et al., 2005) on estimates of serum lipid area under the curve (AUC) for the NIOSH cohort. These data were used previously by Steenland et al. (2001) in combination with a first-order elimination model with an 8.7-year half-life to estimate cumulative serum lipid concentration (equivalent to AUC) for these workers for use in cancer dose-response assessment. Serum lipid TCDD measurements taken in 1988 for a subset of the cohort were combined with the NIOSH job exposure matrix and work histories to estimate dose rates per unit of exposure score. We evaluated the effect of choices in regression model (regression on untransformed vs. ln-transformed data and inclusion of a nonzero regression intercept) as well as the impact of choices of elimination models and parameters on estimated AUCs for the cohort. Central estimates for dose rate parameters derived from the serum-sampled subcohort were applied with the elimination models to time-specific exposure scores for the entire cohort to generate AUC estimates for all cohort members. Use of the CADM resulted in improved model fits to the serum sampling data compared to the first-order models. Dose rates varied by a factor of 50 among different combinations of elimination model, parameter sets, and regression models. Use of a CADM results in increases of up to five-fold in AUC estimates for the more highly exposed members of the cohort compared to estimates obtained using the first-order model with 8.7-year half-life. This degree of variation in the AUC estimates for this cohort would affect substantially the cancer potency estimates derived from the mortality data from this cohort. Such variability and uncertainty in the reconstructed serum lipid AUC estimates for this cohort, depending on elimination model, parameter set, and regression model, have not been described previously and are critical components in evaluating the dose-response data from the occupationally exposed populations.     

Young Adult and Parent Perceptions of Facilitation: Associations with Overparenting,Family Functioning,and Student Adjustment

Overparenting occurs when parents engage in developmentally inappropriate involvement in their children’s lives. This topic is salient in the context of young adults attending college, as this developmental stage necessitates independent decision-making and adjustment on the part of these students. At the same time, the turbulence involved in this transition might engender parental interference and facilitation that could impact young adults’ adjustment and perceived family functioning. This study used structural equation modeling to examine overparenting, perceived interference, facilitation, student adjustment, and family functioning in 302 parent–young adult dyads. Results indicated that overparenting was associated with facilitation, but not interference. Whereas this association was negative for young adults, it was positive for parents. This pattern was also reflected in the indirect effects of overparenting on student adjustment through young adults’ versus parents’ perceived facilitation. Young adults appear to have better outcomes when they perceive their parents to be facilitating their goals.     

In Circle: A Healthy Relationship,Domestic Violence,and HIV Intervention for African American Couples

While marriage and healthy relationship education has grown, limited interventions have been developed specifically to support the development and flourishing of African American couples. African Americans are also disproportionately impacted by HIV/AIDS and are more likely to experience lethality and serious injury due to domestic violence compared to Whites. Despite this, African American couples have been resilient and managed to thrive in relationships. Little has been done to capture these strategies, build on cultural strengths, and design an intervention specifically crafted for this population. This article describes an intervention “In Circle” developed, implemented, and evaluated for African American couples to support healthy relationship and healthy marriage education. The intervention is based on an Ancient Egyptian value system and undergirded by three integrated theoretical perspectives. The article also includes implications for practice and research.     

Collective Bargaining and the Gender Pay Gap in the Printing Industry

This paper considers the effect of collective bargaining on the gender pay gap in the printing industry. This sector was subject to multi‐employer bargaining for around 90 years, until 2010. The article analyses gendered collective bargaining processes through the mechanism of symbolic power, that is, the power of interpretation and definition, and utilizes Walton and McKersie's seminal work on bargaining behaviour to understand the processes that have prevented the closing of the pay gap. It finds that symbolic power operates within the sub‐processes of attitudinal structuring and intra‐organizational bargaining to de‐legitimize women's role in equal pay bargaining, alongside distributive bargaining tactics that preclude equal pay bargaining, thereby creating the impression that women are irrelevant to bargaining processes and ensuring relative invisibility for issues of importance to equality bargaining.     

The Effects of Culture on the Meaning of Loneliness

The present study examined the influence of culturalbackground on the experience of loneliness. Threehundred and seventy five participants from NorthAmerica and 375 from Croatia volunteered to answer an82 item questionnaire which examined the quality oftheir loneliness experiences. The factors whichcomprise the experience of loneliness are Emotionaldistress, Social inadequacy and alienation, Growth anddiscovery, Interpersonal isolation, andSelf-alienation. Results indicated that culturalbackground, indeed, affects the experience ofloneliness. North Americans scored higher on all fivefactors, and a similar trend was evident when men andwomen were compared across cultures.     

Development and Consideration of Global Policies for Managing the Future Risks of Poliovirus Outbreaks: Insights and Lessons Learned Through Modeling

The success of the Global Polio Eradication Initiative promises to bring large benefits, including sustained improvements in quality of life (i.e., cases of paralytic disease and deaths avoided) and costs saved from cessation of vaccination. Obtaining and maintaining these benefits requires that policymakers manage the transition from the current massive use of oral poliovirus vaccine (OPV) to a world without OPV and free of the risks of potential future reintroductions of live polioviruses. This article describes the analytical journey that began in 2001 with a retrospective case study on polio risk management and led to development of dynamic integrated risk, economic, and decision analysis tools to inform global policies for managing the risks of polio. This analytical journey has provided several key insights and lessons learned that will be useful to future analysts involved in similar complex decision-making processes.     

Do We Have Tb Do This? The Children Act 1989 and Obtaining Children's Views in Early Childhood Settings

How do professionals working with young children seek not only to listen to them, but to identify what the children are really saying and to assess their opinion on matters of importance to them? This paper seeks to help people working in early years settings, looking at the evidence from research and day-to-day practice - both organisational and direct contact. Though the orientation is towards educators, other professionals will see common issues for their communication with young children.     

Disaster Relief as Social Action: A Weberian Look at Postdisaster Donation Behavior

Disaster relief involves a broad range of participants, which often results in a disjunction between actual disaster needs and the perception of appropriate strategies in relief provision. This research examines data collected through interviews with donation drive operators responding to Superstorm Sandy in 2012 and the May 2013 Oklahoma tornadoes. Using Weber's ideal types of social action to understand motivations for engaging in disaster relief, this article argues that motivations for participating in and organizing such drives influence donation strategies, and these motivations can be used to explain persistent donation of nonuseful materiel items. Findings indicate several different motivations for involvement and that donation type appeared linked to motivation. We suggest that motivation for engaging in social action is a valuable approach to better understanding donation behavior and, consequently, addressing the social problem of materiel convergence in the postdisaster environment.