Administration of daily 5 mg tadalafil improves endothelial function in patients with benign prostatic hyperplasia

Introduction: Tadalafil is a promising phosphodiesterase (PDE) 5 inhibitor prescribed for erectile dysfunction (ED). Daily low dose (5?mg) of tadalafil has also been used for the treatment of male lower urinary tract symptoms (LUTS) associated with benign prostate hyperplasia (BPH). PDE5 inhibitors induce relaxation of smooth muscle cells in the urethra, prostate, bladder neck, and blood vessels. The aim of this study was to investigate the efficacy of tadalafil on vessels endothelial function, in patients with male LUTS symptoms associated with BPH.

Methods: The Institutional Review Board (IRB) approved this clinical study and informed consents had been obtained from 81 BPH patients.

The following male LUTS parameters: international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), voiding volume, max and mean voiding flow on voiding flowmetry examination and post-voiding residual urine (RU) were compared at 0, 1, 3, 6, and 12 months after a daily dose of 5?mg tadalafil.

In addition, erectile function was evaluated by the sexual health inventory for men (SHIM) score and vessels endothelial function and peripheral neuropathy were assessed by the brachial-ankle pulse wave velocity (baPWV), ankle brachial index (ABI), and vibration perception threshold (VPT) at 0, 3, 6, and 12 months after treatment.

Results: The mean age of 81 patients was 66.4?±?11.4 years old. Their prostate size was 30.2?±?22.1?ml.

Male LUTS parameters including IPSS, OABSS, and RU showed significant improvement from 1 to 12 months after tadalafil administration. Max and mean voiding flow was significantly increased at 6 months after tadalafil treatment.

The SHIM score showed significant improvement after 3 months. Whilst, the results of baPWV also showed significant improvement from 3 to 12 months. ABI was also significantly improved at 6 months. However, there was no change in the VPT at any time point.

Conclusions: Tadalafil is effective for both male LUTS and ED. It is also shown that tadalafil improves baPWV, which we can conclude that higher vessels elasticity has been obtained. This major finding of this study shows that tadalafil has the potency to improve vessels endothelial dysfunction in patients with BPH.     

The Influence of Maternal Socialization on Infants’ Social Evaluation in Two Cultures

Although a growing body of research has explored the early development of social evaluation, no research has directly compared social evaluations of infants between different cultures. In addition, there has been little understanding regarding socialization's effects on this ability. The goal of this study was to expand on earlier findings on social evaluation in infants by investigating a broader sample from two cultures, and to explore the influence of maternal socialization on infants’ social evaluation. Using the violation of expectations and the preferential reaching paradigm, four groups aged 6‐, 9‐, 12‐, and 15–18 months and their mothers from Japan and the United States (159 dyads) were compared in terms of spontaneous social evaluations. Japanese and European American infants showed similar performance in dishabituation to the inconsistent behavior and in their reaching preference for prosocial over antisocial agents, indicating that the emergence of spontaneous social evaluation is not culture‐specific. Furthermore, our study provides a novel finding regarding the relationship between mothers’ socially evaluative speech and infants’ preference for prosocial over antisocial agents. These results suggest that the development of sociomoral understanding results from complicated interactions among evolutionary, cognitive, and social factors.     

Exploring patterns of personal growth initiative and posttraumatic stress: A latent profile analysis

Objective: This study examined the inconsistent relationship found between personal growth initiative (PGI) and posttraumatic stress symptoms (PTSS) by exploring potential subgroups. In addition, after identifying the subgroups, potential predictors of these subgroups were examined. Participants: Participants were 534 undergraduate students who experienced a potentially traumatic event (PTE). Data collection occurred from March 2013 to December 2014. Methods: Because this was a preliminary study, archival data was used. Participants consisted of students who experienced a PTE within the past three years. Results: Latent profile analysis indicated a five-class model as the best-fitting model. Direct exposure and intentionality of the event were significant predictors of class membership; length of time since event and gender did not predict class membership. Conclusions: The current study provides a potential explanation of the inconsistent results between PGI and PTSS and also highlights the importance of acknowledging subgroups when utilizing PGI after a PTE.     

Study on workloads of human care worker with the introduction of IT system - the characteristics of work loads by observational research and the suggestions for KAIZEN

The purpose of this study was to clarify the characteristic of workloads on human care worker with the introduction of IT system, and suggested the support measures for KAIZEN in Japan. The investigation method is workflow line and hearing with a focus on work observation. The objects were 8 human care workers of the acute hospital that introduced an electronic system. By the introduction of the electronic chart, the nurse station sojourn time decreased, sickroom sojourn time increased, and time about direct nursing care to a patient increased. In addition, access to patient information became easy, and the offer of the health care service based on correct information came to be possible in real time. By The point of workflow line, it was effect that moving lengths decreased in order to install the electronic chart in patients' rooms. Though, it was a problem that it hasn't formed where to place the instruments such as sphygmomanometer, clinical thermometer and others.     

Development of the workflow kine systems for support on KAIZEN

In this paper, we introduce the new workflow line system consisted of the location and image recording, which led to the acquisition of workflow information and the analysis display. From the results of workflow line investigation, we considered the anticipated effects and the problems on KAIZEN. Workflow line information included the location information and action contents information. These technologies suggest the viewpoints to help improvement, for example, exclusion of useless movement, the redesign of layout and the review of work procedure. Manufacturing factory, it was clear that there was much movement from the standard operation place and accumulation residence time. The following was shown as a result of this investigation, to be concrete, the efficient layout was suggested by this system. In the case of the hospital, similarly, it is pointed out that the workflow has the problem of layout and setup operations based on the effective movement pattern of the experts. This system could adapt to routine work, including as well as non-routine work. By the development of this system which can fit and adapt to industrial diversification, more effective "visual management" (visualization of work) is expected in the future.     

Crime,Search, and Ex‐offenders’ Accessibility to Labor Markets

Rehabilitation for ex‐offenders has positive (e.g. more production) and negative (e.g. more crime) effects on society. We investigate the effect of rehabilitation on criminal behavior and the labor market using a search model. In the case where ex‐offenders cannot join the labor market, promoting rehabilitation for them may reduce crime. In such a case, the equilibrium allocation may be inefficient. Moreover, under the Hosios condition, equilibrium labor market tightness is lower than the efficient outcome because of crime, as the crime option raises the value of unemployed workers. Because this option works as a negative externality on matched firms, equilibrium tightness is lower than the optimal level.     

Not Just the Price of Food: Challenges of an Urban Agriculture Organization in Engaging Local Residents

This case study of a community‐supported agriculture (CSA) organization in New Orleans focuses on the lack of participation in the CSA market by the local residents despite its intentions, and how various constituencies diagnose the causes of the disengagement. Interview and ethnographic observation data indicate a general consensus on the economic constraints, but some non‐resident supporters of the organization attributed the issue to lack of knowledge about the food system or the benefits of local food consumption. The residents, on the other hand, pointed to spatial and sociocultural barriers that made the market and its location less accessible to them, including the produce selection and purchase options, convenience of access to the market, and the race‐related historical and spatial context of the market's location. These findings suggest that the food access concerns of the food justice movement may be more easily addressed than the food sovereignty concerns. Food as a unique resource poses an additional challenge for the movement to construct an effective food justice frame.