政府改革的时机与方案

政府职能扩大意味着纳税人要为行政部门提供的公共服务缴纳更多的税款——同时要求更多回报。为了满足这些期望,公共部门本身必须改革。     

Dealing with excess of zeros in the statistical analysis of magnetic resonance imaging lesion count in multiple sclerosis

Lesion count observed on brain magnetic resonance imaging scan is a common end point in phase 2 clinical trials evaluating therapeutic treatment in relapsing remitting multiple sclerosis (MS). This paper compares the performances of Poisson, zero‐inflated poisson (ZIP), negative binomial (NB), and zero‐inflated NB (ZINB) mixed‐effects regression models in fitting lesion count data in a clinical trial evaluating the efficacy and safety of fingolimod in comparison with placebo, in MS. The NB and ZINB models prove to be superior to the Poisson and ZIP models. We discuss the advantages and limitations of zero‐inflated models in the context of MS treatment. Copyright © 2012 John Wiley & Sons, Ltd.     

欧洲1958年以来的变革

由雅克·阿塔利（Jacques Attali）所主持的“法国经济增长解放委员会”向尼古拉·萨科齐提交了一份报告。由于受到了自由主义经济思想的启发，首批公开发表的建议把购买力中的许多问题归结为缺乏竞争力的结果。委员会引用了以前的一个著名例子：50年前由戴高乐将军主持拟订的阿尔芒-吕夫（Armand-Rueff）报告。这个报告旨在实现法国经济自由化，从而使得法国能够称霸欧洲。