The Effect of Evaluator Masculinity on Dyadic Hiring Decisions

Gender Issues - Research examining gender disparities in the workplace tends to focus on individual behavior rather than the behavior of teams or dyads, yet important workplace decisions such as...     

Predicting the Financial Vulnerability of Charitable Organizations

This article describes a model that can be used to predict which nonprofit organizations are vulnerable to financial problems. The model is based on financial indicators developed by Tuckman and Chang (1991), adapts methodologies that have been developed in the for‐profit sector to predict financial vulnerability, and was empirically tested using a multiyear Internal Revenue Service database provided by the National Center for Charitable Statistics. Both internal and external stakeholders can use the model when making allocation decisions during the strategic planning process and in evaluating financial risk.     

REVIEWS

Bigner, J. J., & Wetchler, J. L. (Eds.). (2004). Relationship therapy with same-sex couples .
Cling, B. J. (Ed.). (2004). Sexualized violence against women and children: A psychology and law perspective .
Folberg, J., Milne, A., & Salem, P., (Eds.). (2004). Divorce and family mediation: Models, techniques and applications .
Rholes, S. W., & Simpson, J. A. (Eds.). (2004). Adult attachment: Theory, research and clinical implications .
Sperry, L. (Ed.). (2004). Assessment of couples and families: Contemporary and cutting edge strategies .     

Modeling Receptor-Mediated Processes with Dioxin: Implications for Pharmacokinetics and Risk Assessment

Dioxin (2,3,7,8-tetrachlorodibenzo- p -dioxin; TCDD), a widespread polychlorinated aromatic hydrocarbon, caused tumors in the liver and other sites when administered chronically to rats at doses as low as 0.01 μg/kg/day. It functions in combination with a cellular protein, the Ah receptor, to alter gene regulation, and this resulting modulation of gene expression is believed to be obligatory for both dioxin toxicity and carcinogenicity. The U.S. EPA is reevaluating its dioxin risk assessment and, as part of this process, will be developing risk assessment approaches for chemicals, such as dioxin, whose toxicity is receptor-mediated. This paper describes a receptor-mediated physiologically based pharmacokinetic (PB-PK) model for the tissue distribution and enzyme-inducing properties of dioxin and discusses the potential role of these models in a biologically motivated risk assessment. In this model, ternary interactions among the Ah receptor, dioxin, and DNA binding sites lead to enhanced production of specific hepatic proteins. The model was used to examine the tissue disposition of dioxin and the induction of both a dioxin-binding protein (presumably, cytochrome P4501A2), and cytochrome P4501A1. Tumor promotion correlated more closely with predicted induction of P4501A1 than with induction of hepatic binding proteins. Although increased induction of these proteins is not expected to be causally related to tumor formation, these physiological dosimetry and gene-induction response models will be important for biologically motivated dioxin risk assessments in determining both target tissue dose of dioxin and gene products and in examining the relationship between these gene products and the cellular events more directly involved in tumor promotion.     

REVIEWS

Hardy, K. V., & Laszloffy, T. A. (2005). Teens who hurt: Clinical interventions to break the cycle of adolescent violence .
Hayes, S. C., Follette, V. M., & Linehan, M. M. (Eds.). (2004). Mindfulness and acceptance: Expanding the cognitive–behavioral tradition .
Swenson, C. C., Henggeler, S., Taylor, I., & Addison, O. (2005). Multisystemic therapy and neighborhood partnerships: Reducing adolescent violence and substance abuse .
Derrig-Palumbo, K., & Zeine, F. (2005). Online therapy: A therapist's guide to expanding your practice .     

REVIEWS

Spring, J. A. (2004). How can I forgive you: The courage to forgive, the freedom not to .
Germer, C. K., Siegel, R., & Fulton, P. (Ed.). (2005). Mindfulness and psychotherapy .
Atkinson, B. J. (2005). Emotional intelligence in couples therapy: Advances from neurobiology and the science of intimate relationships .
Guterman, J. T. (2006). Mastering the art of solution-focused counseling .
Harris, S., Ivey, D., & Bean, R. (2005). A practice that works: Strategies to complement your stand alone therapy practice .     

Accountability in Nonprofit Organizations

Accountability, Performance Reporting, Comprehensive Audit: An Integrated Perspective, by Guy LeClerc, W. David Moynagh, Jean-Pierre Boisclair, and Hugh R. Hanson. Ottawa: CCAF-FCVI (Canadian Comprehensive Auditing Foundation- Fondation Canadienne pour la Verification Integral), 1996. 373 pp., $85.00 (Canadian, plus shipping) cloth. Managing for Accountability: Preserving the Public Trust in Public and Nonprofit Organizations, by Kevin P. Kearns. San Francisco: Jossey-Bass, 1996. 255 pp., $27.95 cloth.