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Concurrent engineering has been widely accepted as a viable strategy for companies to reduce time to market and achieve overall cost savings. This article analyzes various risks and challenges in product development under the concurrent engineering environment. A three‐dimensional early warning approach for product development risk management is proposed by integrating graphical evaluation and review technique (GERT) and failure modes and effects analysis (FMEA). Simulation models are created to solve our proposed concurrent engineering product development risk management model. Solutions lead to identification of key risk controlling points. This article demonstrates the value of our approach to risk analysis as a means to monitor various risks typical in the manufacturing sector. This article has three main contributions. First, we establish a conceptual framework to classify various risks in concurrent engineering (CE) product development (PD). Second, we propose use of existing quantitative approaches for PD risk analysis purposes: GERT, FMEA, and product database management (PDM). Based on quantitative tools, we create our approach for risk management of CE PD and discuss solutions of the models. Third, we demonstrate the value of applying our approach using data from a typical Chinese motor company.  相似文献   
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In this work, we consider nonparametric estimation of QAL distribution in a three-state illness–death model. In our approach, we first write down the expression for the distribution of QAL in terms of the joint distribution of the sojourn times in the three states. The estimate of the QAL distribution is obtained by substituting the estimates of sojourn time distributions in the expression of the QAL distribution. The proposed nonparametric estimate, assuming independence between time to illness and sojourn time in the state of illness, is uniformly consistent. Asymptotic normality has also been established. An estimate of asymptotic variance has been obtained. The performance of the proposed estimator is investigated by simulation. A data set of the Stanford Heart Transplant program has been analyzed for illustration.  相似文献   
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This article proposes an intertemporal risk‐value (IRV) model that integrates probability‐time tradeoff, time‐value tradeoff, and risk‐value tradeoff into one unified framework. We obtain a general probability‐time tradeoff, which yields a formal representation form to reflect the psychological distance of a decisionmaker in evaluating a temporal lottery. This intuition of probability‐time tradeoff is supported by robust empirical findings as well as by psychological theory. Through an explicit formalization of probability‐time tradeoff, an IRV model taking into account three fundamental dimensions, namely, value, probability, and time, is established. The object of evaluation in our framework is a complex lottery. We also give some insights into the structure of the IRV model using a wildcatter problem.  相似文献   
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A mixture experiment is an experiment in which the response is assumed to depend on the relative proportions of the ingredients present in the mixture and not on the total amount of the mixture. In such experiment process, variables do not form any portion of the mixture but the levels changed could affect the blending properties of the ingredients. Sometimes, the mixture experiments are costly and the experiments are to be conducted in less number of runs. Here, a general method for construction of efficient mixture experiments in a minimum number of runs by the method for projection of efficient response surface design onto the constrained region is obtained. The efficient designs with a less number of runs have been constructed for 3rd, 4th, and 5th component of mixture experiments with one process variable.  相似文献   
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In this article, we consider a simple transient queuing system, i.e., a linear birth process with immigration in the presence of twin births. We find the differential-difference equation and also the probability-generating function (p.g.f.) for this process. Again, we generalize it into a linear birth process with immigration in the presence of both single birth or twin births and again for the case of multiple births. From the p.g.f. of linear birth process with immigration in the presence of twin births, we find some particular transient queuing processes like linear birth process with twin births and simple immigration process. Direct derivations of mean and variance of these processes are also discussed without using the generating functions.  相似文献   
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Dominant approaches to sustainability have focused on environmental governance with efficient mechanisms and technical quick-fixes for regulatory changes and policy reforms within the growth-centred economic model. However, they fail to develop an authentic ‘ecological citizenship’ for a more fundamental change in the framework of moral values guiding individuals' behaviour and attitude towards the environment and their choices to live lightly on earth. This article argues that the transformation to a sustainable society necessitates deeper moral changes and the development of an ecological morality at the individual level as the core of sustainability. The article examines the distinctiveness of the Gandhian approach to ‘ecological citizenship’ within his paradigm of non-violence and ethical holism as an alternative to the dominant thinking. Within his broader moral-philosophical framework, the paper focuses on Gandhi's theories of eco-localism, unity of life, economics of well-being, and the moral praxis of subordinating the material to moral development realized by the human self through an ‘inner revolution’ with a goal to improve the ‘quality of man’, moving beyond the conventional ‘fear–greed’ dichotomy as motivators of behaviour to bring about a societal transformation towards a sustainable society based on freedom, equity, justice, and peace.  相似文献   
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It is well‐known that a spontaneous reporting system suffers from significant under‐reporting of adverse drug reactions from the source population. The existing methods do not adjust for such under‐reporting for the calculation of measures of association between a drug and the adverse drug reaction under study. Often there is direct and/or indirect information on the reporting probabilities. This work incorporates the reporting probabilities into existing methodologies, specifically to Bayesian confidence propagation neural network and DuMouchel's empirical Bayesian methods, and shows how the two methods lead to biased results in the presence of under‐reporting. Considering all the cases to be reported, the association measure for the source population can be estimated by using only exposure information through a reference sample from the source population. Copyright © 2014 John Wiley & Sons, Ltd.  相似文献   
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