Three-level main-effects designs exploiting prior information about model uncertainty

To explore the projection efficiency of a design, Tsai, et al [2000. Projective three-level main effects designs robust to model uncertainty. Biometrika 87, 467–475] introduced the Q criterion to compare three-level main-effects designs for quantitative factors that allow the consideration of interactions in addition to main effects. In this paper, we extend their method and focus on the case in which experimenters have some prior knowledge, in advance of running the experiment, about the probabilities of effects being non-negligible. A criterion which incorporates experimenters’ prior beliefs about the importance of each effect is introduced to compare orthogonal, or nearly orthogonal, main effects designs with robustness to interactions as a secondary consideration. We show that this criterion, exploiting prior information about model uncertainty, can lead to more appropriate designs reflecting experimenters’ prior beliefs.     

Development of predictive signatures for treatment selection in precision medicine with survival outcomes

For survival endpoints in subgroup selection, a score conversion model is often used to convert the set of biomarkers for each patient into a univariate score and using the median of the univariate scores to divide the patients into biomarker‐positive and biomarker‐negative subgroups. However, this may lead to bias in patient subgroup identification regarding the 2 issues: (1) treatment is equally effective for all patients and/or there is no subgroup difference; (2) the median value of the univariate scores as a cutoff may be inappropriate if the sizes of the 2 subgroups are differ substantially. We utilize a univariate composite score method to convert the set of patient's candidate biomarkers to a univariate response score. We propose applying the likelihood ratio test (LRT) to assess homogeneity of the sampled patients to address the first issue. In the context of identification of the subgroup of responders in adaptive design to demonstrate improvement of treatment efficacy (adaptive power), we suggest that subgroup selection is carried out if the LRT is significant. For the second issue, we utilize a likelihood‐based change‐point algorithm to find an optimal cutoff. Our simulation study shows that type I error generally is controlled, while the overall adaptive power to detect treatment effects sacrifices approximately 4.5% for the simulation designs considered by performing the LRT; furthermore, the change‐point algorithm outperforms the median cutoff considerably when the subgroup sizes differ substantially.     

Is the Easy Life Always the Happiest? Examining the Association of Convenience and Well-Being in Taiwan

Social scientists have under-examined neighborhood stores and other “resources” and their relationships to community welfare and personal happiness. Because the presence of neighborhood conveniences may signify that a neighborhood caters to residents’ needs and smoothes out the hassles of their daily lives, it could be hypothesized that commercial amenities and services enhance individuals’ satisfaction with their neighborhoods, with their health, and even with their lives as a whole. This study used a national probability sample from Taiwan, a densely populated society in East Asia, to test if service-oriented commercial and religious enterprises in neighborhoods are associated with positive estimations of well-being by those who occupy these spaces. We empirically examine whether proximity to main roads, night markets and temples or proximity to smoky food stands and other shops that produce pungent products affects well-being. Our findings from multivariate analyses suggest that if nearby conveniences are conceived as annoyances, they tend to lower satisfaction with neighborhood, but they do not lower life satisfaction in general. In contrast, air quality, along with “peace and quietness” is reported by respondents to be key in enhancing general well-being. We discuss the policy implications in the concluding session.     

Point subtraction aggression paradigm: validity of a brief schedule of use

The Point Subtraction Aggression Paradigm (PSAP) is a validated behavioral measure of aggression in response to provocation. Canonically, multiple sessions continue until performance asymptotes, requiring significant time. We sought to examine whether use of the PSAP-first-session ("PSAP-FS") had acceptable construct validity for group data, potentially expanding the settings in which the PSAP may be useful. One hundred male and female young adult subjects completed the PSAP-FS and additional behavioral measures of aggression, and provided information related to risk factors. The PSAP-FS correlated significantly with known risk factors of aggression. The PSAP-FS, which measures aggression in the present, correlated well with measures of recent aggression and less strongly with life history of aggression. The PSAP-FS had satisfactory validity properties for use where group-level data are of interest.     

法藏敦煌藏文本P．T.99号《正说圣妙吉祥名》相关问题研究

文章将敦煌藏文写本P.T.99号中的写本<正说圣妙吉祥名>与<甘珠尔>中所收规范本进行比较,论述二者的异同和相互间的关系.对该经的最初传授者和翻译者,经考证认为是密宗大师无垢友和吐蕃译师聂·杂那.提出释智的汉译本应属西夏时期的译本,依据类似敦煌本的藏文本翻译,认为该经在汉藏佛教文化交流中占有重要地位.     

Benevolence-dominant,authoritarianism-dominant,and classical paternalistic leadership: Testing their relationships with subordinate performance

We propose a new typology of paternalistic leadership styles based on how leaders demonstrate authoritarianism and benevolence, the two essential components of this type of leadership. Benevolence-dominant paternalistic leadership refers to leaders' sole dependence on the use of benevolence without their strong assertion of authority, whereas authoritarianism-dominant paternalistic leadership is based mainly on authoritarianism itself; classical paternalistic leadership, which best fits early observations of paternalistic leaders, refers to the salient combination of both leadership components. We used two distinct samples and methods to test this typology and the association with subordinate performance. Across the two studies, a field investigation with Taiwanese military supervisor-subordinate dyads and a hypothetical scenario experiment with U.S. working adults, we found a positive relationship between classical paternalistic leadership and subordinate performance as strong as that between benevolence-dominant paternalistic leadership and performance. Our findings echo the phenomenon that paternalistic leaders tend to combine benevolence with authoritarianism to affect subordinate performance.     

Enabling robust assessment of QTc prolongation in early phase clinical trials

Since the implementation of the International Conference on Harmonization (ICH) E14 guideline in 2005, regulators have required a “thorough QTc” (TQT) study for evaluating the effects of investigational drugs on delayed cardiac repolarization as manifested by a prolonged QTc interval. However, TQT studies have increasingly been viewed unfavorably because of their low cost effectiveness. Several researchers have noted that a robust drug concentration‐QTc (conc‐QTc) modeling assessment in early phase development should, in most cases, obviate the need for a subsequent TQT study. In December 2015, ICH released an “E14 Q&As (R3)” document supporting the use of conc‐QTc modeling for regulatory decisions. In this article, we propose a simple improvement of two popular conc‐QTc assessment methods for typical first‐in‐human crossover‐like single ascending dose clinical pharmacology trials. The improvement is achieved, in part, by leveraging routinely encountered (and expected) intrasubject correlation patterns encountered in such trials. A real example involving a single ascending dose and corresponding TQT trial, along with results from a simulation study, illustrate the strong performance of the proposed method. The improved conc‐QTc assessment will further enable highly reliable go/no‐go decisions in early phase clinical development and deliver results that support subsequent TQT study waivers by regulators.     

An Examination of the Dual Model of Perfectionism and Adolescent Athlete Burnout: A Short-Term Longitudinal Research

The dual model of perfectionism (Slade and Owens, Behav Modificat 22(3):372–390, 1998) is adopted to examine the influence of adaptive and maladaptive perfectionism on adolescent athlete burnout in Taiwan. Participants were 188 high school adolescent student-athletes (M = 16.48, SD = .59). They were administered the Multidimensional Inventory of Perfectionism in Sport (Stoeber et al., Pers Individ Dif 43(1):131–141, 2007) and the Chinese Athlete Burnout Questionnaire (ABQ) (Lu et al., Phys Educ J 39(3):83–94, 2006). A field longitudinal design was used. In cross-sectional analyses, hierarchical multiple regressions indicated that adaptive perfectionism negatively predicted athlete burnout while maladaptive perfectionism had an inverse relationship with burnout. However, after controlling for the initial scores of burnout, neither adaptive nor maladaptive perfectionism significantly predicted athlete burnout after a three month interval. Possible mechanisms of this relation, limitations, and practical implications are discussed.