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1.
Craig H. Mallinckrodt Christopher J. Kaiser John G. Watkin Michael J. Detke Geert Molenberghs Raymond J. Carroll 《Pharmaceutical statistics》2004,3(3):171-186
The last observation carried forward (LOCF) approach is commonly utilized to handle missing values in the primary analysis of clinical trials. However, recent evidence suggests that likelihood‐based analyses developed under the missing at random (MAR) framework are sensible alternatives. The objective of this study was to assess the Type I error rates from a likelihood‐based MAR approach – mixed‐model repeated measures (MMRM) – compared with LOCF when estimating treatment contrasts for mean change from baseline to endpoint (Δ). Data emulating neuropsychiatric clinical trials were simulated in a 4 × 4 factorial arrangement of scenarios, using four patterns of mean changes over time and four strategies for deleting data to generate subject dropout via an MAR mechanism. In data with no dropout, estimates of Δ and SEΔ from MMRM and LOCF were identical. In data with dropout, the Type I error rates (averaged across all scenarios) for MMRM and LOCF were 5.49% and 16.76%, respectively. In 11 of the 16 scenarios, the Type I error rate from MMRM was at least 1.00% closer to the expected rate of 5.00% than the corresponding rate from LOCF. In no scenario did LOCF yield a Type I error rate that was at least 1.00% closer to the expected rate than the corresponding rate from MMRM. The average estimate of SEΔ from MMRM was greater in data with dropout than in complete data, whereas the average estimate of SEΔ from LOCF was smaller in data with dropout than in complete data, suggesting that standard errors from MMRM better reflected the uncertainty in the data. The results from this investigation support those from previous studies, which found that MMRM provided reasonable control of Type I error even in the presence of MNAR missingness. No universally best approach to analysis of longitudinal data exists. However, likelihood‐based MAR approaches have been shown to perform well in a variety of situations and are a sensible alternative to the LOCF approach. MNAR methods can be used within a sensitivity analysis framework to test the potential presence and impact of MNAR data, thereby assessing robustness of results from an MAR method. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
2.
Craig J. Thompson 《The Sociological quarterly》2003,44(1):81-107
Social critics of the natural health movement charge that it indoctrinates consumers in a therapeutic consumerist ideology. This "dominated consumer" thesis ignores that socially situated individuals must negotiate a plethora of institutionally specific power structures aiming to classify and govern their identities. Accordingly, resistance toward specific institutional constructions of identity can be produced through marketplace ideologies. I explore this understudied ideological effect by analyzing the narratives of women who are using natural health alternatives to resist their ascribed medico-administrative identities. Natural health's therapeutic ideology enables these women to contest the degenerative implications of their medical diagnoses and, conversely, to reconstruct their chronic illnesses as an opportunity for discovering their inner regenerative potential and expanding their spiritual horizons. This analysis has implications for prior studies suggesting that resistance toward the technocratic and bureaucratic aspects of conventional medicine exemplifies a Foucauldian "care of the self." I argue that a postmodern adaptation of Foucauldian theory is needed to address the complex interrelationships among the care of the self, medical consumerism, and the therapeutic ideology of the natural health marketplace. 相似文献
3.
Craig H. Mallinckrodt John G. Watkin Geert Molenberghs Raymond J. Carroll 《Pharmaceutical statistics》2004,3(3):161-169
Missing data, and the bias they can cause, are an almost ever‐present concern in clinical trials. The last observation carried forward (LOCF) approach has been frequently utilized to handle missing data in clinical trials, and is often specified in conjunction with analysis of variance (LOCF ANOVA) for the primary analysis. Considerable advances in statistical methodology, and in our ability to implement these methods, have been made in recent years. Likelihood‐based, mixed‐effects model approaches implemented under the missing at random (MAR) framework are now easy to implement, and are commonly used to analyse clinical trial data. Furthermore, such approaches are more robust to the biases from missing data, and provide better control of Type I and Type II errors than LOCF ANOVA. Empirical research and analytic proof have demonstrated that the behaviour of LOCF is uncertain, and in many situations it has not been conservative. Using LOCF as a composite measure of safety, tolerability and efficacy can lead to erroneous conclusions regarding the effectiveness of a drug. This approach also violates the fundamental basis of statistics as it involves testing an outcome that is not a physical parameter of the population, but rather a quantity that can be influenced by investigator behaviour, trial design, etc. Practice should shift away from using LOCF ANOVA as the primary analysis and focus on likelihood‐based, mixed‐effects model approaches developed under the MAR framework, with missing not at random methods used to assess robustness of the primary analysis. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
4.
Craig C. Lundberg 《International Journal of Value-Based Management》1992,5(1):107-117
This paper focuses upon an as yet under-explored factor believed to underlie most managerial and organizational behavior variables—work ideology. Work ideologies are surveyed for several convenience samples of students and managers to show their ability to be studied and that patterned differences may be discovered. In addition, the historical origins and meanings of four major work ideologies are discussed. 相似文献
5.
6.
Craig Stow 《Risk analysis》2002,22(1):185-185
7.
Gary Craig 《Social Policy & Administration》1992,26(2):129-143
This paper briefly reviews the deteriorating position of the poor in the UK in recent years; summarizes the range of action and research initiatives that has developed to address the problem of poverty; and suggests an agenda of principles to inform further action and research. 相似文献
8.
"This article examines the probable effects of the North American Free Trade Agreement (NAFTA) on migration from Mexico to the United States, disputing the view that expansion of jobs in Mexico could rapidly reduce undocumented migration. To the extent that NAFTA causes Mexican export agriculture to expand, migration to the United States will increase rather than decrease in the short run. Data collected in both California and the Mexican State of Baja California show that indigenous migrants from southern Mexico typically first undertake internal migration, which lowers the costs and risks of U.S. migration. Two features of employment in export agriculture were found to be specially significant in lowering the costs of U.S. migration: first, working in export agriculture exposes migrants to more diverse social networks and information about U.S. migration; second, agro-export employment in northern Mexico provides stable employment, albeit low-wage employment, for some members of the family close to the border (especially women and children) while allowing other members of the family to assume the risks of U.S. migration." 相似文献
9.
Sussman S Galaif ER Newman T Hennesy M Pentz MA Dent CW Stacy AW Moss MA Craig S Simon TR 《Evaluation review》1997,21(1):94-123
Little documentation exists regarding the functioning of formalized adolescent groups as drug abuse prevention agents. Two studies are described that were conducted at high schools whose students are at high risk for drug abuse. Twenty-one schools were randomly assigned to one of three conditions: (a) standard care, (b) classroom drug abuse education only, or (c) classroom plus school-as-community. Results of the first study indicated that the school-as-community component--which involved weekly meetings and periodic events at seven schools--was implemented as planned, drug abused focused, and perceived as productive in discouraging drug abuse. In the second study, staff in the classroom plus school-as-community condition self-reported involvement in the greatest number of community activities across the school year, compared with staff from the other two conditions. These two studies support the feasibility of formalized groups of high-risk youth to promote drug-free events. 相似文献
10.
Environmental scanning is a broadly defined concept, having first received attention from scholars in the late 1960s. Over the years a number of similar and overlapping constructs have emerged in management literature. The aim of this study, via a systematic review and thematic analysis of relevant empirical research, is to consolidate foundation environmental scanning knowledge, demonstrate how scanning research has developed and fragmented over time, and propose an agenda for future research. The first contribution of our review is a new typology of environmental scanning research made up of five discrete research views, which provides a more comprehensive and contemporary overview of the field than previous studies. The second is a proposed agenda for future research that explicitly acknowledges the role of technology, an area that is presently underdeveloped in foundation scanning literature. The third contribution is to signpost future directions for research on scanning and organisational performance using a number of theoretical perspectives. The overall outcome of our review is to move scanning research on from increasingly incremental contributions concerned with context to a place where the changing role of technology and the mechanisms through which environmental scanning contributes to competitive advantage can be more thoroughly understood. 相似文献