医疗需求与中国医疗费用增长——基于城乡老年医疗支出差异的视角

在人口老龄化和老年医疗支出城乡差异凸显的背景下,中国医疗费用增长部分源于合理的健康需求。利用中国营养与健康调查1991—2011年的八轮数据,构造出生组跟踪样本,分别考察城乡居民医疗支出的年龄效应,估算城乡老年医疗需求导致的费用上涨,可以发现:城市居民的人均医疗支出随年龄显著增加,但农村居民的人均医疗支出随年龄增长的趋势并不明显。而忽略出生组效应,会低估城乡老年医疗支出的差距。城乡老年医疗支出差距缩小,将导致医疗费用在2010—2030年年均实际增长约5.2%。在控制医疗总费用上涨的同时,医疗保险制度需根据老年医疗需求,调整医疗资源配置结构。     

Environmental Justice in the Context of Scientifi Uncertainty: On the Safety of Genetically Modifi Organisms

应对风险特别是科学不确定性所导致的风险，实现和维护环境正义是当今时代的 一个前沿核心议题。转基因生物安全为代表的科学不确定性背景下的环境正义，需要 建立在相应的科学研究基础之上，但在本质上乃是一种社会构建。对转基因生物技术 及其产品等现代科技的研发、应用和推广等活动，应当维护其市场自由，与此同时， 为了公共安全以及社会弱势群体的最大利益，还应当对相关科技活动进行必要的政府 干预和法律规制。     

Interval estimation for conformance proportions of multiple quality characteristics

A conformance proportion is an important and useful index to assess industrial quality improvement. Statistical confidence limits for a conformance proportion are usually required not only to perform statistical significance tests, but also to provide useful information for determining practical significance. In this article, we propose approaches for constructing statistical confidence limits for a conformance proportion of multiple quality characteristics. Under the assumption that the variables of interest are distributed with a multivariate normal distribution, we develop an approach based on the concept of a fiducial generalized pivotal quantity (FGPQ). Without any distribution assumption on the variables, we apply some confidence interval construction methods for the conformance proportion by treating it as the probability of a success in a binomial distribution. The performance of the proposed methods is evaluated through detailed simulation studies. The results reveal that the simulated coverage probability (cp) for the FGPQ-based method is generally larger than the claimed value. On the other hand, one of the binomial distribution-based methods, that is, the standard method suggested in classical textbooks, appears to have smaller simulated cps than the nominal level. Two alternatives to the standard method are found to maintain their simulated cps sufficiently close to the claimed level, and hence their performances are judged to be satisfactory. In addition, three examples are given to illustrate the application of the proposed methods.     

Inference and Decision Making for 21st-Century Drug Development and Approval

ABSTRACT

The cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making.     

Ethical Numbers: Ethics Training in U.S. Graduate Statistics Programs, 2013–2014

As important members of research teams, statisticians bear an ethical responsibility to analyze, interpret, and report data honestly and objectively. One way of reinforcing ethical responsibilities is through required courses covering a variety of ethics-related topics at the graduate level. We assessed ethics requirements for graduate-level statistics training programs in the United States for the 2013–2014 academic year using the websites of 88 universities, examining 103 biostatistics programs, and 136 statistics degree programs. We categorized programs’ ethics training requirements as required or not required. Thirty-one (35.1%) universities required an ethics course for at least some degree students. Sixty-two (25.5%) degree programs required an ethics course for at least some students. The majority (77.4%) of required courses were worth 0 or 1 credit. Of the 177 programs without an ethics requirement, 19 (10.7%) listed an ethics elective. Although a single ethics course is insufficient for instilling an ethical approach to science, degree programs that model expectations through coursework point to the value of ethics in science. More training programs should prepare statisticians to consider the ethical dimensions of their work through required coursework. Supplementary materials for this article are available online.     

Foreign-born and native-born migration in the U.S.: evidence from linked IRS administrative and census survey records

Journal of Population Research - This paper details efforts to link administrative records from the Internal Revenue Service (IRS) to American Community Survey (ACS) and 2010 Census microdata for...     

Institutional Constraints and Deforestation: An Application to Mexico

Following North (1990), this article hypothesizes that effective rural institutions may impose additional costs on tropical deforestation through agricultural conversion. This allows a formal agricultural household analysis of institutional constraints on deforestation and therefore a method of empirically testing whether there is any significant difference in the actual level of forest land conversion under institutional constraints compared to the level of conversion under pure open access. A dynamic panel analysis for agricultural planted area in Mexico at state level and over the 1960–85 period confirms that institutional constraints on land clearing affected deforestation during the pre-NAFTA era.     

Characterizations of two power indices for voting games with r alternatives

In the first three sections of this paper we present a set of axioms which provide a characterization of an extension of the Banzhaf index to voting games with r alternatives, such as the United Nations Security Council where a nation can vote “yes”, “no”, or “abstain”. The fourth section presents a set of axioms which characterizes a power index based on winning sets instead of pivot sets. Received: 4 April 2000/Accepted: 30 April 2001     

"人因"--现代灾害的主要致灾源

1999年自然灾害频发,如台湾、土耳其、希腊的大地震,苏丹、柬埔寨等地的洪水,肆虐美国的飓风……据联合国再保险公司的穆尼黑·雷先生统计,20世纪90年代全球自然灾害数量是60年代的3倍.地处伦敦的格赖恩灾害研究中心的科学家们分析,20世纪60年代和70年代,是全球地震相对沉寂的时期,人们对地震逐渐放松了警惕,很多富人在地震活跃带大兴土木,人口逐渐密集.因而土耳其等地的地震使那么多人伤亡,亦不足为奇.     

德国行政赔偿制度的特色与成因

德国行政赔偿制度有着不同于大陆法系国家和普通法系国家行政赔偿制度的特色,这种特色突出体现在行政赔偿基础的赔偿请求权和对行政赔偿案件进行救济的赔偿审理制度两个方面。德国行政赔偿制度的特色是由在漫长的历史过程中所形成的思想因素、制度因素和文化因素造就而成。