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We study competition and coordination in a supply chain in which a single supplier both operates a direct channel and sells its product through multiple differentiated retailers. We study analytically the supply chain with symmetric retailers and find that the supplier prefers to have as many retailers as possible in the market, even if the retailers' equilibrium retail price is lower than that of the supplier, and even if the number of retailers and their cost or market advantage prevent sales through the direct channel. We find that the two‐channel supply chain may be subject to inefficiencies not present in the single‐channel supply chain. We show that several contracts known to coordinate a single‐channel supply chain do not coordinate the two‐channel supply chain; thus we propose a linear quantity discount contract and demonstrate its ability to perfectly coordinate the two‐channel supply chain with symmetric retailers. We provide some analytical results for the supply chain with asymmetric retailers and propose an efficient solution approach for finding the equilibrium. We find numerically that the supplier still benefits from having more retailers in the market and that linear quantity discount contracts can mitigate supply chain inefficiency, though they no longer achieve perfect coordination.  相似文献   
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The current study examined the impact of financial costs and self-reported economic pressure on the quality of life of patients with progressive neurological illness. Participants were 423 people from four illness groups in Australia. Participants completed measures of (a) quality of life, (b) income, (c) expenses, (d) economic pressure, (e) social support, (f) relationship satisfaction, and (g) severity of illness. There was a strong negative association between quality of life and economic pressure (but not income or expenses) for all groups. Subjective assessment of economic pressure was strongly associated with quality of life for people with motor neurone disease and multiple sclerosis. Implications of these results for assisting people with progressive neurological illnesses to cope with the financial changes that occur due to their illness are discussed.  相似文献   
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Elodie Adida 《Risk analysis》2011,31(10):1622-1631
An effective nonpharmaceutical intervention for influenza interrupts an exposure route that contributes significantly to infection risk. Herein, we use uncertainty analysis (point‐interval method) and Monte Carlo simulation to explore the magnitude of infection risk and predominant route of exposure. We utilized a previously published mathematical model of a susceptible person attending a bed‐ridden infectious person. Infection risk is sensitive to the magnitude of virus emission and contact rates. The contribution of droplet spray exposure to infection risk increases with cough frequency, and decreases with virus concentration in cough particles. We consider two infectivity scenarios: greater infectivity of virus deposited in the upper respiratory tract than virus inhaled in respirable aerosols, based on human studies; and equal infectivity in the two locations, based on studies in guinea pigs. Given that virus have equal probability of infection throughout the respiratory tract, the mean overall infection risk is 9.8 × 10?2 (95th percentile 0.78). However, when virus in the upper respiratory tract is less infectious than inhaled virus, the overall infection risk is several orders of magnitude lower. In this event, inhalation is a significant exposure route. Contact transmission is important in both infectivity scenarios. The presence of virus in only respirable particles increases the mean overall infection risk by 1–3 orders of magnitude, with inhalation contributing ≥ 99% of the infection risk. The analysis indicates that reduction of uncertainties in the concentration of virus in expiratory particles of different sizes, expiratory event frequency, and infectivity at different sites in the respiratory tract will clarify the predominate exposure routes for influenza.  相似文献   
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Farmers’ attitudes, to agricultural production, diversification and policy support, and behavioural intentions in five Member States of the EU (France, Lithuania, Slovakia, Sweden, England) are analysed comparatively. Groups of farmers with similarly held attitudes are identified using cluster analysis to investigate whether differences in attitudes are defined predominately according to national, east–west, size or other criteria. The results highlight that the vast majority of farmers in the enlarged EU retain a productivist mindset, wish to maintain an agricultural focus and strongly reject notions of policy liberalisation. However, while the overwhelming majority advocate protection they are more receptive to greater flexibility in terms of the instruments through which policy support may be delivered. Overall, the strongest opposition to policy liberalisation comes from farmers in the New Member States of the EU.  相似文献   
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We identify market conditions under which intermediaries can thrive in retailer‐driven supply chains. Our main finding is that, as a consequence of the retailers’ leadership position, intermediaries prefer products for which the supply base (existing production capacity) is neither too narrow nor too broad; that is, less existing capacity can result in more intermediary profit. We also show that our main finding is robust to (i) the presence of horizontal competition among retailers and intermediaries, (ii) the existence of exclusive suppliers, and (iii) the ability of the retailers to source directly from the suppliers. Nevertheless, we find that horizontal competition between intermediaries encourages them to carry products with relatively smaller production capacity, whereas exclusive suppliers and direct sourcing encourage intermediaries to carry products with relatively larger installed capacity.  相似文献   
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The quasi-revolutionary events of May 1968 have come to symbolize the generation gap between young people and their elders in France, and of contestation over social values, freedom and control. This article demonstrates that this discontent was apparent earlier in the decade, although politicians in charge of youth affairs either did not see it or chose not to publicize its existence. It focuses on debates relating to sport – and its incorporation into the teaching of physical education in lycées – because of its importance both within formal schooling and as an extra-curricular leisure activity. In 1966 François Missoffe, Minister of Youth Affairs and Sport, launched a huge inquiry into the problems facing young people, leading to the publication of an official report in 1967 which, perhaps surprisingly, had nothing to say about unrest among young people. This article aims to access the voices of young people in French lycées by mining the contents of over 2600 files of evidence that were collected during the course of the Missoffe inquiry. We argue that it is important to measure the gap between what the political and educational decision-makers presupposed about the sporting needs of young people and the views these same young people actually expressed. The article highlights examples of young people’s disillusionment with the teaching of sport and physical education, demonstrating that this not only conveyed signs of discontent with educational institutions as a whole but also a wider desire for social change that anticipated the views of angry lycéens (school pupils) in May 1968.  相似文献   
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Models of influenza transmission have focused on the ability of vaccination, antiviral therapy, and social distancing strategies to mitigate epidemics. Influenza transmission, however, may also be interrupted by hygiene interventions such as frequent hand washing and wearing masks or respirators. We apply a model of influenza disease transmission that incorporates hygiene and social distancing interventions. The model describes population mixing as a Poisson process, and the probability of infection upon contact between an infectious and susceptible person is parameterized by p. While social distancing interventions modify contact rates in the population, hygiene interventions modify p. Public health decision making involves tradeoffs, and we introduce an objective function that considers the direct costs of interventions and new infections to determine the optimum intervention type (social distancing versus hygiene intervention) and population compliance for epidemic mitigation. Significant simplifications have been made in these models. However, we demonstrate that the method is feasible, provides plausible results, and is sensitive to the selection of model parameters. Specifically, we show that the optimum combination of nonpharmaceutical interventions depends upon the probability of infection, intervention compliance, and duration of infectiousness. Means by which realism can be increased in the method are discussed.  相似文献   
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