Sex differences in the development of mild cognitive impairment and probable Alzheimer’s disease as predicted by hippocampal volume or white matter hyperintensities

This study examined biological sex differences in the development of mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) development as predicted by changes in the hippocampus or white matter hyperintensities. A secondary data analysis of the National Alzheimer’s Coordinating Center Uniform Data Set was conducted. We selected samples of participants with normal cognition at baseline who progressed to MCI (n = 483) and those who progressed to probable AD (n = 211) to determine if hippocampal volume or white matter hyperintensities (WMH) at baseline predicted progression to probable AD or MCI and whether the rate of progression differed between men and women. The survival analyses indicated that changes in hippocampal volumes affected the progression to probable AD (HR = 0.535, 95% CI [0.300–0.953]) only among women. White men had an increased rate of progression to AD (HR = 4.396, CI [1.012–19.08]; HR = 4.665, 95% CI [1.072–20.29]) compared to men in other race and ethnic groups. Among women, increases in hippocampal volume ratio led to decreased rates of progressing to MCI (HR = 0.386, 95% CI [0.166–0.901]). Increased WMH among men led to faster progression to MCI (HR = 1.048. 95% CI [1.011–1.086]). Women and men who were older at baseline were more likely to progress to MCI. In addition, results from longitudinal analyses showed that women with a higher CDR global score, older age at baseline, or more disinhibition symptoms experienced higher odds of MCI development. Changes in hippocampal volumes affect the progression to or odds of probable AD (and MCI) more so among women than men, while changes in WMH affected the progression to MCI only among men.     

Follow My Gaze: Face Race and Sex Influence Gaze‐Cued Attention in Infancy

Using the eye gaze of others to direct one's own attention develops during the first year of life and is thought to be an important skill for learning and social communication. However, it is currently unclear whether infants differentially attend to and encode objects cued by the eye gaze of individuals within familiar groups (e.g., own race, more familiar sex) relative to unfamiliar groups (e.g., other race, less familiar sex). During gaze cueing, but prior to the presentation of objects, 10‐month‐olds looked longer to the eyes of own‐race faces relative to 5‐month‐olds and relative to the eyes of other‐race faces. After gaze cueing, two objects were presented alongside the face and at both ages, infants looked longer to the uncued objects for faces from the more familiar‐sex and longer to cued objects for the less familiar‐sex faces. Finally, during the test phase, both 5‐ and 10‐month‐old infants looked longer to uncued objects relative to cued objects but only when the objects were cued by an own‐race and familiar‐sex individual. Results demonstrate that infants use face eye gaze differently when the cue comes from someone within a highly experienced group.     

Young Women's Experiences and Perceptions of Cunnilingus during Adolescence

Recent studies indicate that cunnilingus may be as prevalent as fellatio among American adolescents. Despite this approximate equivalence in rates, there is an imbalance in the amount and type of attention paid to fellatio and cunnilingus. Furthermore, there has been little empirical examination of young women's experiences and perceptions of cunnilingus during adolescence. Two studies in response to this gap in knowledge were conducted. In Study 1, regression analyses indicated that a young woman's sexual assertiveness was linked to having more lifetime cunnilingus partners, as well as more cunnilingus experiences in the past three months. Study 2 explored young women's perceptions of cunnilingus and their speculations about their male partners’ perceptions thereof. Linear mixed modeling revealed that participants had highly favorable impressions of cunnilingus, which they believed their male partners shared. These findings are considered in terms of positive adolescent sexual development and cultural norms regarding female sexuality.     

Young women's experiences and perceptions of cunnilingus during adolescence

Recent studies indicate that cunnilingus may be as prevalent as fellatio among American adolescents. Despite this approximate equivalence in rates, there is an imbalance in the amount and type of attention paid to fellatio and cunnilingus. Furthermore, there has been little empirical examination of young women's experiences and perceptions of cunnilingus during adolescence. Two studies in response to this gap in knowledge were conducted. In Study 1, regression analyses indicated that a young woman's sexual assertiveness was linked to having more lifetime cunnilingus partners, as well as more cunnilingus experiences in the past three months. Study 2 explored young women's perceptions of cunnilingus and their speculations about their male partners' perceptions thereof. Linear mixed modeling revealed that participants had highly favorable impressions of cunnilingus, which they believed their male partners shared. These findings are considered in terms of positive adolescent sexual development and cultural norms regarding female sexuality.