初中生良好家庭教育环境的构建

初中生所处的时期既是"黄金期"又是"危险期",对他们的教育更显得重要。然而家长最了解,也最容易影响孩子;孩子很依赖父母,也就最容易接受父母的教育;家庭教育又是人生所受的第一个教育,也具有其它教育无法比拟的优势,所以家长要意识到家庭教育环境的重要性、提高自身素质、掌握初中生的身心特点、为他们营造良好的家庭教育环境,进而更好地配合学校及社会对他们的教育。     

Immune shaping and the development of Alzheimer's disease vaccines

Given the emotional, social, and financial devastation wrought by Alzheimer's disease (AD), it is imperative that effective therapeutics be devised to ameliorate this presently incurable disorder. Vaccine-based approaches have been developed to target and eliminate amyloid beta (Abeta), a key peptide implicated in AD pathogenesis. Preclinical successes in AD mouse models created excitement and impetus for the clinical application of an Abeta-based vaccine. Eliciting immune responses against a self-peptide (that is, a peptide produced by the organism itself), such as Abeta, carries with it the potential to induce autoimmune and inflammatory conditions in the vaccinated individual, a caveat borne out in multiple patients enrolled as part of a recent clinical trial. These clinical adverse events seemingly overshadowed interesting behavioral stabilization and alterations of Abeta burden in these and other vaccinated patients, thus speaking to the potential of immunotherapy for AD. Understanding the mechanisms by which vaccines reduce Abeta burden in AD brain and the types of immune responses raised, as well as developing new modalities of vaccine delivery that facilitate the modulation of elicited immune responses, will undoubtedly lead to a new generation of efficacious Abeta immunotherapeutics with improved safety profiles.