A novel method was used to incorporate in vivo host–pathogen dynamics into a new robust outbreak model for legionellosis. Dose‐response and time‐dose‐response (TDR) models were generated for Legionella longbeachae exposure to mice via the intratracheal route using a maximum likelihood estimation approach. The best‐fit TDR model was then incorporated into two L. pneumophila outbreak models: an outbreak that occurred at a spa in Japan, and one that occurred in a Melbourne aquarium. The best‐fit TDR from the murine dosing study was the beta‐Poisson with exponential‐reciprocal dependency model, which had a minimized deviance of 32.9. This model was tested against other incubation distributions in the Japan outbreak, and performed consistently well, with reported deviances ranging from 32 to 35. In the case of the Melbourne outbreak, the exponential model with exponential dependency was tested against non‐time‐dependent distributions to explore the performance of the time‐dependent model with the lowest number of parameters. This model reported low minimized deviances around 8 for the Weibull, gamma, and lognormal exposure distribution cases. This work shows that the incorporation of a time factor into outbreak distributions provides models with acceptable fits that can provide insight into the in vivo dynamics of the host‐pathogen system. 相似文献
Federal and other regulatory agencies often use or claim to use a weight of evidence (WoE) approach in chemical evaluation. Their approaches to the use of WoE, however, differ significantly, rely heavily on subjective professional judgment, and merit improvement. We review uses of WoE approaches in key articles in the peer‐reviewed scientific literature, and find significant variations. We find that a hypothesis‐based WoE approach, developed by Lorenz Rhomberg et al., can provide a stronger scientific basis for chemical assessment while improving transparency and preserving the appropriate scope of professional judgment. Their approach, while still evolving, relies on the explicit specification of the hypothesized basis for using the information at hand to infer the ability of an agent to cause human health impacts or, more broadly, affect other endpoints of concern. We describe and endorse such a hypothesis‐based WoE approach to chemical evaluation. 相似文献
In recent decades the House Sparrow and Tree Sparrow have suffered considerable declines. To date, little is known about the fine scale habitat selection of sparrows where they occur together. We investigated how sympatric sparrows used macro and microhabitats in the urban environment of Guwahati city. Survey of sparrows was carried out in 572 locations of different urban settings to find out the city scale distribution. We classified urban habitats and collected micro-habitat variables at 45 point count stations during 2013–2015. Urbanization gradient was found to be influential in limiting the abundance of sparrows. House Sparrow was more common within the urbanized areas compared to low settlement densities located far from the urban core. In contrast, Tree Sparrows were more scattered and seldom found in crowded areas. Spatial overlap was comparatively high in the residential areas adjacent to hillocks. At micro scale, House Sparrow had quadratic response to the degree of urbanization. Both the species avoided areas where urbanization reached the peak; specifically, the areas which were completely devoid of natural vegetation and top soil was paved, and in shopping centers with glass facades. Habitat requirements of both the species at local landscape scale seemed to be similar, although, with some overlaps, they occupied different gradients of the urban environment. Since urban landscapes are highly managed, the fundamental tool for enhancing urban sparrow populations would be the protection of mosaic habitat prioritizing suitable design and management of private gardens and allotments.
Extending the works of scholars who have elucidated writing as the quintessential site for social transformation, the aim of this article is to locate the myriad possibilities for actualizing Donna Haraway's concept of cyborg writing in the field of organization studies. I contend that cyborg writing functions as a discursive mechanism by which to disrupt Enlightenment ideals of Cartesian duality, objectivity and rationality. These ideals inform the very structure of masculine privilege that emerge from having a society that is organized along androcentric values. Situating the scholarship of Jo Brewis, a contemporary scholar in the field, I illuminate how cyborg writing can be practised effectively, whereby greater richness is imparted into conceptualizations of, and theorizing on, organizational and management phenomena. I conclude with a discussion of the implications of cyborg writing, and with the identification of two trajectories that scholars can pursue in future studies. Progress along these two paths will move towards actualizing the feminist project for gender egalitarianism. 相似文献
The paper explores the degree to which Indigenous groups perceive that resource management plans they develop are able to help deliver outcomes they seek through formal planning systems. It does this by a case study of practice in Aotearoa New Zealand. Some Indigenous groups are concerned they are being encouraged to devote considerable effort to production of major planning documents for use in interaction with environmental agencies, yet in practice, such plans can appear to have a limited role in bringing about desired change or affecting wider planning processes. The research contributes a New Zealand dimension to this international debate. 相似文献
The scientific community has pronounced climate change unequivocal and its consequences disastrous. Yet Americans' behavioral response to the global social problem of environmental degradation has been largely confined to the individual act of recycling. This article examines why Americans are not doing more to address climate change and other environmental issues. Taking a cognitive sociological perspective, I describe how Americans think about environmental issues and pro‐environmental behavior. I draw on Swidler's concept of a “cultural tool kit,” to examine the cultural narratives Americans use to account for the small amount of pro‐environmental behavior they perform. The act of recycling functions as a synecdoche for pro‐environmental behavior in general, allowing individuals to over‐claim the significance of a modest amount of pro‐environmental behavior. I argue that Americans' failure to engage with environmental issues at a collective level is rooted in the individualized culture of American environmentalism. 相似文献