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Casey Crump Kenny Crump Eric Hack Rose Luippold Kenneth Mundt Elizabeth Liebig Julie Panko Dennis Paustenbach Deborah Proctor 《Risk analysis》2003,23(6):1147-1163
This study evaluates the dose-response relationship for inhalation exposure to hexavalent chromium [Cr(VI)] and lung cancer mortality for workers of a chromate production facility, and provides estimates of the carcinogenic potency. The data were analyzed using relative risk and additive risk dose-response models implemented with both Poisson and Cox regression. Potential confounding by birth cohort and smoking prevalence were also assessed. Lifetime cumulative exposure and highest monthly exposure were the dose metrics evaluated. The estimated lifetime additional risk of lung cancer mortality associated with 45 years of occupational exposure to 1 microg/m3 Cr(VI) (occupational exposure unit risk) was 0.00205 (90%CI: 0.00134, 0.00291) for the relative risk model and 0.00216 (90%CI: 0.00143, 0.00302) for the additive risk model assuming a linear dose response for cumulative exposure with a five-year lag. Extrapolating these findings to a continuous (e.g., environmental) exposure scenario yielded an environmental unit risk of 0.00978 (90%CI: 0.00640, 0.0138) for the relative risk model [e.g., a cancer slope factor of 34 (mg/kg-day)-1] and 0.0125 (90%CI: 0.00833, 0.0175) for the additive risk model. The relative risk model is preferred because it is more consistent with the expected trend for lung cancer risk with age. Based on statistical tests for exposure-related trend, there was no statistically significant increased lung cancer risk below lifetime cumulative occupational exposures of 1.0 mg-yr/m3, and no excess risk for workers whose highest average monthly exposure did not exceed the current Permissible Exposure Limit (52 microg/m3). It is acknowledged that this study had limited power to detect increases at these low exposure levels. These cancer potency estimates are comparable to those developed by U.S. regulatory agencies and should be useful for assessing the potential cancer hazard associated with inhaled Cr(VI). 相似文献
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Ian Butler Lesley Scanlan Margaret Robinson Gillian Douglas Mervyn Murch 《Children & Society》2002,16(2):89-102
The paper reports findings from a research study that explored children's experience of divorce. It shows that children experience parental divorce as a crisis in their lives but that they are able to mobilise internal and external resources to regain a new point of balance. In doing so, children demonstrate the degree to which they are active and competent participants in the process of family dissolution. The implications of the data are then considered in relation to engaging with children involved in divorce and in relation to some of the cultural presumptions that might militate against hearing what they have to say about their experiences. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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This paper provides a contemporary and comprehensive review of work in the marketing channel field that is based on French and Raven's power‐base theory. It traces the development of theoretic, conceptual and methodological orthodoxies from the 1970s. Mirroring the movement towards the relationship marketing paradigm, the paper considers the theory's empirical contribution to knowledge of power, conflict, trust and commitment in marketing channels. Limitations relating to inconsistency of treatment, contradictory findings and the simplification of complex phenomena are identified. Nevertheless, current work extends power‐base theory to other cultures, other styles of research and to the area of supply chains. The review raises questions about the value of contribution made using this theory and notes the surprising absence within the channels literature of the broader, current debate about power. To illustrate, the paper shows how Clegg's (1989. Frameworks of Power. London: Sage) circuits of power framework, if applied to channel contexts, could address forms of power that are invisible, anonymous and not necessarily negative. Applications and methods are discussed, opening a space wherein a broadened understanding of power is integrated within a focus upon cooperative channels. 相似文献
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Gillian Schofield Jeanette Cossar Emma Ward Birgit Larsson Pippa Belderson 《Child & Family Social Work》2019,24(3):372-381
The experiences and needs of lesbian, gay, bisexual, trans and queer/questioning (LGBTQ) young people in care have been overlooked in England, in both policy and research. This paper reports on findings from the first study of LGBTQ young people in care in England and focuses on the nature of foster carers' experiences and perspectives on caring for LGBTQ young people. Qualitative interviews regarding the fostering role in caring for LGBTQ young people were conducted with a sample of foster carers (n = 26) and analysed thematically. Foster carers described the importance of offering LGBTQ young people not only the nurturing relationships that all children in care need but also availability, sensitivity and acceptance to help young people manage stigma and other challenges associated with minority sexual orientation and gender identity. The Secure Base caregiving model provided a framework for analysing the different dimensions of these relationships. Understanding caregiving roles and relationships for LGBTQ young people in care has important implications for recruiting, training, matching and supporting foster carers to care for LGBTQ young people effectively. 相似文献
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Barnett K Buys L Lovie-Kitchin J Boulton-Lewis G Smith D Heffernan M 《Journal of women & aging》2007,19(3-4):179-193
Women's fear of violence can impact negatively on their active participation in life. An ageing survey conducted with 2,620 Australian respondents aged 50 to 90 years examined aspects of work, learning, social, spiritual and emotional status, health, vision, home, life events, demographics, and asked an open-ended question about what being actively engaged in life meant. Ordinal regression was carried out on two dependent variables: wanting and needing to learn to discourage violence. Analyses found that as women's age increased, those on lower incomes were more likely than others to say they needed to learn how to discourage violence against them. This paper investigates the variables associated with the findings-transport, finances, news media, home safety, and reduced social interactions. Results highlight the importance of understanding women's fear in the context of personal and social issues, and the need to provide learning opportunities to improve safety and social engagement. 相似文献
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Gillian Gualtieri 《Sociological Forum》2020,35(1):207-228
This article considers how American colleges and universities responded to rapid legal change around Title IX immediately following the 2011 release of the Office for Civil Rights’ Dear Colleague Letter. By analyzing the content of 250 campus sexual harassment policies, this article finds that contrary to the predictions of the employment discrimination literature, which suggests that the largest, most visible institutions in a field are the most likely to embed markers of symbolic compliance in their formal policies, small baccalaureate colleges are more likely to include references to the law in their formal documents than their research university peers do. To understand this intriguing finding, the article then analyzes 15 interviews with campus administrators at research universities and baccalaureate colleges to uncover the distinct logics of symbolic compliance and student concerns that differentially inform how actors at different kinds of institutions inhabit their roles and endogenously interpret new Title IX regulations in their formal policies and campus practices. In doing so, this article illuminates the ways in which processes of legal endogeneity differ across institution types within the broader field of higher education. 相似文献
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