The time‐dependent “cure‐death” model investigating two equally important endpoints simultaneously in trials treating high‐risk patients with resistant pathogens

A variety of primary endpoints are used in clinical trials treating patients with severe infectious diseases, and existing guidelines do not provide a consistent recommendation. We propose to study simultaneously two primary endpoints, cure and death, in a comprehensive multistate cure‐death model as starting point for a treatment comparison. This technique enables us to study the temporal dynamic of the patient‐relevant probability to be cured and alive. We describe and compare traditional and innovative methods suitable for a treatment comparison based on this model. Traditional analyses using risk differences focus on one prespecified timepoint only. A restricted logrank‐based test of treatment effect is sensitive to ordered categories of responses and integrates information on duration of response. The pseudo‐value regression provides a direct regression model for examination of treatment effect via difference in transition probabilities. Applied to a topical real data example and simulation scenarios, we demonstrate advantages and limitations and provide an insight into how these methods can handle different kinds of treatment imbalances. The cure‐death model provides a suitable framework to gain a better understanding of how a new treatment influences the time‐dynamic cure and death process. This might help the future planning of randomised clinical trials, sample size calculations, and data analyses.     

A Scoping Review of Challenges in Adult Intimate Relationships After Childhood Sexual Abuse

Childhood sexual abuse is a severe problem worldwide. Childhood sexual abuse can be detrimental to children and their abilities to cope with and communicate in their subsequent adult intimate relationships. The aim of this review was to generate and summarize knowledge about how childhood sexual abuse manifests in adult intimate relationships so healthcare professionals can incorporate this knowledge into treatment and care. A scoping review methodology was selected because it supports examination of the extent, range, and nature of research activity. A content analysis of the studies included in this review led to three thematic categories of challenges in adult intimate relationships after childhood sexual abuse: (a) relationship satisfaction, (b) sexual satisfaction, and (c) communication and trust.     

The reconstruction of childhood–implications for theory and practice

First, the article deals with selected aspects of change that have framed the lives of contemporary families and children in Scandinavia: urbanization; secularization and norm-pluralism; changes in work-conditions; ideologies about the role of mothers; structural changes in family patterns; and the modern professionalization of care. Second, how change induces a crisis in the grand developmental approach within child psychology is investigated. It is argued that any a priori universal and non-contextual derived type of knowledge about development fails to grasp what is going on within families and in care and socialization in rapidly changing cultures such as Scandinavia and other Western European countries. An alternative paradigm is presented that should make us better able to understand development as embedded in culture and time. Third, some new challenges for educating the skilled practitioner are focused upon. Here reflective competence will be addressed: expertise as an ‘eternal process of inquiry; the ability to use multi-based and often conflicting knowledge about families and children in order to solve problems in everyday situations; the strengthened emphasis on the practitioner-as-person and the ability to use practical and reflected knowledge in different contexts. Finally, new bases of scientific knowledge are suggested for use in the future education of practitioners.     

Structure and agency between French and Morphogenetic Régulation

This article examines the gradual evolution of the French Régulation school (FR) for the study of capitalism through the lens of structure and agency. The analysis first segments the school into two epochs, the early Régulation, led by authors Aglietta and Lipietz, and the later Régulation, which saw the rise of Boyer. We find that the gradual progression that occurred within the FR school is linked to its authors' implicit ontic engagement with structure and agency, which, in turn, provides natural linkages to Critical Realism. In the second part of the paper, we demonstrate how the comparison between Morphogenetic Régulation and French Régulation (FR) can facilitate a much deeper reading of the structure-agency debate pertaining to the transformation of capitalism. In so doing, it discusses the value addedness of Morphogenetic Régulation through three specific concepts by stressing their relevance for contemporary studies in international political economy. These concepts are: stratified emergence; causality and the problématique of hierarchy.     

No Compelling Evidence That Newborns Imitate Oral Gestures

Newborns (N = 83) were presented with 3 conditions, each for 160 sec: tongue protrusion (TP), mouth opening (MO), and control (CO). In TP and MO, a female model alternated between demonstrating the gesture for 20 sec and presenting a passive, motionless face for 20 sec. In CO, she presented a passive face in both the “demonstration” and “passive” intervals. The participants' eyes were more widely open in the demonstration intervals of TP and MO than in the passive intervals, indicating that they were attending to the gestures. In TP, the participants produced more TP responses than MO responses, but in MO there was no effect, undermining the neonatal imitation hypothesis.     

Appetite for Destruction? China,Ecologically Unequal Exchange,and Forest Loss

We test the hypothesis from the theory of ecologically unequal exchange that agricultural exports to China are related to increased forest loss in low- and middle-income nations exporting to it. We do so by analyzing data for 75 low- and middle-income nations using ordinary least squares regression. We find support for our hypothesis that flows of agricultural exports from low- and middle-income nations to China are related to increased forest loss in exporting nations. We also find that a country's total agricultural exports, proximity of forest to infrastructure, and protected areas tend to increase forest loss.