Dutasteride improves bone mineral density in male patients with lower urinary tract symptoms and prostatic enlargement: a preliminary study

Introduction: We studied the effect of dutasteride on bone mineral density (BMD) in aging male patients with lower urinary tract symptoms (LUTS) and prostatic enlargement.

Methods: We prospectively studied 17 patients with LUTS and prostatic enlargement. Before and 1 year after dutasteride (0.5?mg daily), we assessed International Prostate Symptom Score (IPSS), prostatic volume (PV), serum prostatic-specific antigen (PSA) and testosterone. BMD in the lumbar and femur was measured by DEXA method.

Results: Dutasteride significantly reduced PV (from 51?±?24 to 34?±?17?ml, p?p?p?2, p?2, p?2, p?Conclusions: Dutasteride has a potential to improve BMD with elevation of serum testosterone in aging male patients with LUTS and prostatic enlargement.     

Trends in old-age functioning and disability in Japan, 1993-2002

Disability is a burden to individuals and society. Population ageing, combined with the fact that disability is most common among the elderly, has focused attention on trends in old-age disability. This study estimates trends in functioning and disability among Japanese elderly from 1993 to 2002 and contrasts the patterns with those found in the USA. Japan is an especially interesting country because its age structure is relatively old, and it currently has the highest life expectancy in the world despite the fact that just 50 years ago its life expectancy was in the bottom half of all countries. As in the USA, disability rates have fallen. If it were not for the gains in disability between 1993 and 2002, there would have been 1.1 million more disabled elderly in 2002. The reductions were experienced broadly across socio-demographic and economic groups. Increases in education across cohorts are associated with the declines in disability.     

The Impact of Social Ties on Depressive Symptoms in U.S. and Japanese Elderly

This study examines the effects of social ties (with spouse, children, friends, neighbors, other relatives, and community groups) on depressive symptom levels in U.S. and Japanese adults aged 60 and over. Nationally representative survey data from the United States ( N = 1,419) and Japan ( N = 2,200) indicate that having a spouse, or increased contacts with friends, neighbors and relatives was associated with fewer depressive symptoms in both samples. The effects of spousal presence were significantly larger in the United States than in Japan. The presence of children was associated with fewer depressive symptoms in Japan only, and this effect was significantly stronger among those currently unmarried as opposed to those who are currently married. We discuss these similarities and differences between countries.