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Multiparameter evidence synthesis in epidemiology and medical decision-making: current approaches 总被引:1,自引:0,他引:1
A. E. Ades A. J. Sutton 《Journal of the Royal Statistical Society. Series A, (Statistics in Society)》2006,169(1):5-35
Summary. Alongside the development of meta-analysis as a tool for summarizing research literature, there is renewed interest in broader forms of quantitative synthesis that are aimed at combining evidence from different study designs or evidence on multiple parameters. These have been proposed under various headings: the confidence profile method, cross-design synthesis, hierarchical models and generalized evidence synthesis. Models that are used in health technology assessment are also referred to as representing a synthesis of evidence in a mathematical structure. Here we review alternative approaches to statistical evidence synthesis, and their implications for epidemiology and medical decision-making. The methods include hierarchical models, models informed by evidence on different functions of several parameters and models incorporating both of these features. The need to check for consistency of evidence when using these powerful methods is emphasized. We develop a rationale for evidence synthesis that is based on Bayesian decision modelling and expected value of information theory, which stresses not only the need for a lack of bias in estimates of treatment effects but also a lack of bias in assessments of uncertainty. The increasing reliance of governmental bodies like the UK National Institute for Clinical Excellence on complex evidence synthesis in decision modelling is discussed. 相似文献
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Jonathan H. Wright 《Econometric Reviews》2002,21(4):397-417
Many recent papers have used semiparametric methods, especially the log-periodogram regression, to detect and estimate long memory in the volatility of asset returns. In these papers, the volatility is proxied by measures such as squared, log-squared, and absolute returns. While the evidence for the existence of long memory is strong using any of these measures, the actual long memory parameter estimates can be sensitive to which measure is used. In Monte-Carlo simulations, I find that if the data is conditionally leptokurtic, the log-periodogram regression estimator using squared returns has a large downward bias, which is avoided by using other volatility measures. In United States stock return data, I find that squared returns give much lower estimates of the long memory parameter than the alternative volatility measures, which is consistent with the simulation results. I conclude that researchers should avoid using the squared returns in the semiparametric estimation of long memory volatility dependencies. 相似文献
5.
Jonathan S. Fish 《The Sociological review》2003,51(2):257-275
This paper critically examines Metrovi? and Maffesoli's attempt to understand postmodernity through Émile Durkheim's nonrational link between society, religion and morality. Metrovi? (1991, 1997) and Maffesoli's (1996) work draws upon this emotional element when attempting to refute Baudrillard's (1983) cognitively focused, if implicit, critique of the Durkheimian tradition. Despite their best intentions, Metrovi? and Maffesoli still fail to exploit the partialities of Baudrillard's critique to the full. While both have some appreciation of the link between emotion and religion as found in Durkheim's The Elementary Forms of Religious Life (1912) they, nevertheless, fall short of grasping its full conceptual importance. This leads them to an implicit acceptance of Baudrillard's thesis on the ‘end’ of the social. This pitfall could have been avoided if Metrovi? and Maffesoli had built their respective analyses of the postmodern condition on a closer reading of The Elementary Forms. Reading this text alongside those other insights on emotion and social life as contained within Durkheim and Mauss's Primitive Classification (1903) and Talcott Parsons's subsequent writings on the sociological problem of religion, would have helped to distance the work of Metrovi? and Maffesoli from that of Baudrillard, and allowed them to offer a stronger and more comprehensive defence of the said tradition. 相似文献
6.
Tracey Maegusuku‐Hewett David Dunkerley Jonathan Scourfield Nina Smalley 《Children & Society》2007,21(4):309-321
This article aims to makes a contribution to redressing a methodological and theoretical imbalance in existing research on refugee and asylum‐seeking children. It draws on two qualitative studies from Wales with children and young people. The samples include unaccompanied minors and children living with families as well as both children who are supported in the asylum system and those who have been granted refugee status. The focus on ecological post‐migratory stressors and coping processes that young people identify as being integral to their well‐being and, once granted status, to how they adapt to settlement includes a selective study of some of the sources of resilience referred to in the children's talk. Recognising the interplay between individual and environment leads to a discussion of both personal attributes and collective cultural identities. 相似文献
7.
Diagnostics for dependence within time series extremes 总被引:1,自引:0,他引:1
Anthony W. Ledford Jonathan A. Tawn 《Journal of the Royal Statistical Society. Series B, Statistical methodology》2003,65(2):521-543
Summary. The analysis of extreme values within a stationary time series entails various assumptions concerning its long- and short-range dependence. We present a range of new diagnostic tools for assessing whether these assumptions are appropriate and for identifying structure within extreme events. These tools are based on tail characteristics of joint survivor functions but can be implemented by using existing estimation methods for extremes of univariate independent and identically distributed variables. Our diagnostic aids are illustrated through theoretical examples, simulation studies and by application to rainfall and exchange rate data. On the basis of these diagnostics we can explain characteristics that are found in the observed extreme events of these series and also gain insight into the properties of events that are more extreme than those observed. 相似文献
8.
Christian P. Robert Xiao-Li Meng Jesper Møller Jeffrey S Rosenthal C Jennison M. A Hurn F Al-Awadhi Peter McCullagh Christophe Andrieu Arnaud Doucet Petros Dellaportas Ioulia Papageorgiou Ricardo S Ehlers Elena A Erosheva Stephen E Fienberg Jonathan J Forster Roger C Gill Nial Friel Peter Green David Hastie R King Hans R Künsch N. A. Lazar C Osinski 《Journal of the Royal Statistical Society. Series B, Statistical methodology》2003,65(1):39-55
9.
Jonathan Bradshaw 《Children & Society》2003,17(3):162-172
This article explores trends in child poverty in the UK since 1979 and examines the extent to which the government is making progress in pursuit of its objective to abolish child poverty in 20 years. The spatial distribution of child poverty is examined by country, local authority and ward. The characteristics of households containing poor children are presented and research on the dynamics of child poverty reviewed. Child poverty in the UK trebled during the 1980s and has only just begun to fall slowly. Child poverty is heavily spatially concentrated and the risks of child poverty are concentrated in certain types of household. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
10.
loveLife is the largest effort ever launched in South Africa to change adolescent sexual behaviour with the aim of reducing the rate of HIV infection among 15–20 year olds by 50%, reducing other STIs, and reducing the incidence of teenage pregnancy. loveLife combines high-powered media awareness and education, development of adolescent-friendly reproductive health services, and outreach and support programmes. The 5-year research and evaluation plan includes a multi-year comprehensive observational study, tracking change in a range of behavioural indicators and in sexual health outcomes. In its first 2 years, loveLife reached more than 4 million youth. Sixty-two percent of youth and 59% of their parents/guardians recognize the brand, while the vast majority of parents (97%) and youth (89%) exposed to loveLife, identified loveLife as being positive. Challenges in the next years are the continued roll out of the programme, and the development of institutional support and behaviour change. 相似文献