杜甫《登高》诗中的乐观主义精神探微

杜甫写于唐大历二年(767年)秋天的《登高》诗,虽是其晚年凄凉与孤独生活状态的真实写照,但诗中却充满着令人激动的气势.这种气势不仅源于杜甫对登高文学传统的继承,亦是其晚年面对迁逝之感时昂扬生命意识的展现.除了感时伤事,诗中还深刻蕴含着杜甫晚年的壮阔情怀以及乐观主义精神,这种精神与夔州相对安定的生活有着密切关联,更是其儒家思想的重要体现.     

湘鄂川黔革命根据地的“扩红运动”及其历史与现实意义

湘鄂川黔革命根据地是长江南岸的最后一块红色根据地,是在全国其他各路红军离开原有根据地后,由红二、六军团会师后建立的,为我国革命战争的胜利起到了不可忽视的作用。文章以"扩红运动"为研究维度,从三个方面进行深刻论析。面对国民党的"围剿"、根据地内反动势力的迫害以及薄弱的地方武装力量,"扩红运动"的组织发动显得迫切需要。"扩红运动"的组织发动不仅对打击封建反动势力、维护苏维埃政权、壮大革命队伍、策应红军长征,以及保卫土地革命成果、扩大中国共产党的影响有着重要的历史意义,而且还对当今密切党群关系、处理民族关系、加强军队建设等都有着重要的现实意义。     

Inference and Decision Making for 21st-Century Drug Development and Approval

ABSTRACT

The cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making.     

Ethical Numbers: Ethics Training in U.S. Graduate Statistics Programs, 2013–2014

As important members of research teams, statisticians bear an ethical responsibility to analyze, interpret, and report data honestly and objectively. One way of reinforcing ethical responsibilities is through required courses covering a variety of ethics-related topics at the graduate level. We assessed ethics requirements for graduate-level statistics training programs in the United States for the 2013–2014 academic year using the websites of 88 universities, examining 103 biostatistics programs, and 136 statistics degree programs. We categorized programs’ ethics training requirements as required or not required. Thirty-one (35.1%) universities required an ethics course for at least some degree students. Sixty-two (25.5%) degree programs required an ethics course for at least some students. The majority (77.4%) of required courses were worth 0 or 1 credit. Of the 177 programs without an ethics requirement, 19 (10.7%) listed an ethics elective. Although a single ethics course is insufficient for instilling an ethical approach to science, degree programs that model expectations through coursework point to the value of ethics in science. More training programs should prepare statisticians to consider the ethical dimensions of their work through required coursework. Supplementary materials for this article are available online.     

Foreign-born and native-born migration in the U.S.: evidence from linked IRS administrative and census survey records

Journal of Population Research - This paper details efforts to link administrative records from the Internal Revenue Service (IRS) to American Community Survey (ACS) and 2010 Census microdata for...     

论历史演义的虚构性

明清时期对历史演义的性质存在着争议,有些评论家认为历史演义是正史的通俗版,因而极力反对在历史演义中进行虚构。但大量的创作实践证明,为了增强作品的可读性,历史演义不可能句句依傍正史,必然在细节描写、心理刻画、语言描写、环境烘托等方面进行虚构,从而使历史演义成为虚实结合的历史小说。     

常德市旅游、商贸宣传品的英译探讨

要达到对外宣传预期的目的 ,旅游、商贸对外宣传品的翻译必须正确、得体、一致。实例表明 ,常德市旅游、商贸对外宣传品的翻译在这些方面普遍存在问题。因此 ,要提高翻译质量 ,除管理者高度重视外 ,译者要加强英、汉语功底的修养 ,培养敬业精神     

20年代初苏俄在外蒙古问题上的对华政策

20世纪20年代初期中苏建交谈判期间,苏俄从其自身国家安全利益出发,采取强行出兵外蒙追剿白匪和坚持长期驻军库伦的作法,来占有当时主权属于中国的外蒙古地区,在外蒙古问题上对华采取了大国沙文主义和民族利己主义政策.     

春秋时期的媵制及其盛行原因

媵制指一个贵族男子娶妻 ,这个妻的侄、娣 (妹 )也随同她一同陪嫁 ,这侄娣随姑、姊同嫁一夫的婚俗 ,在春秋时期的诸侯和士大夫中相当盛行 ,对春秋时期的政治联盟、社会稳定和婚姻外交起过十分重要的作用。这种制度的盛行 ,不仅与史前文化的遗存及西周春秋时期的宗法继承制有关 ,而且与春秋时期特殊的历史背景和现实需要有关     

促性腺激素、V_(D_3)、V_E亚硒酸钠对母兔繁殖力的影响

选择成年、健康、未孕母兔 32只 ,随机分成 8组 ,分别给予促性腺激素 (Ⅰ组 )、VD3(Ⅱ组 )、VE 亚硒酸钠 (Ⅲ组 ) ,促性腺激素 +VD3(Ⅳ组 )、VD3+VE 亚硒酸钠 (Ⅴ组 )、促性腺激素 +VE 亚硒酸钠(Ⅵ组 )、促性腺激 +VD3+VE 亚硒酸钠 (Ⅶ组 ) ,空白对照 8种处理。试验结果表明 ,母兔经药物处理后 ,其繁殖性能 (发情状况、排卵数、正常受精卵数 )都比对照组显著地提高 ,但Ⅰ、Ⅳ、Ⅵ组有畸形卵子存在 ,以处理Ⅶ组效果最好 ,其排卵数达 4 7± 2 0 .3个 ,正常受精卵 35个 ,分别比对照组多 36 .5个、30个。