Modification of GEE1 and linear mixed-effects models for heteroscedastic longitudinal Gaussian data

A characterization of GLMs is given. Modification of the Gaussian GEE1, modified GEE1, was applied to heteroscedastic longitudinal data, to which linear mixed-effects models are usually applied. The modified GEE1 models scale multivariate data to homoscedastic data maintaining the correlation structure and apply usual GEE1 to homoscedastic data, which needs no-diagnostics for diagonal variances. Relationships among multivariate linear regression methods, ordinary/generalized LS, naïve/modified GEE1, and linear mixed-effects models were discussed. An application showed modified GEE1 gave most efficient parameter estimation. Correct specification of the main diagonals of heteroscedastic data variance appears to be more important for efficient mean parameter estimation.     

Effects of testosterone replacement therapy on hypogonadal men with osteopenia or osteoporosis: a subanalysis of a prospective randomized controlled study in Japan (EARTH study)

Objective: We investigated the effects of testosterone replacement therapy (TRT) on bone mineral density (BMD) among hypogonadal men with osteopenia/osteoporosis.

Methods: From our previous EARTH study population, 74 patients with a clinical diagnosis of osteopenia or osteoporosis and hypogonadism were included in this study, as the TRT (n?=?35) and control (n?=?34) groups. The TRT group was administered 250?mg of testosterone enanthate injection every 4 weeks for 12 months. The BMD, waist circumference, body mass index, body fat percentage, and muscle volume were measured at baseline and at 12 months. Blood biochemical data, including total cholesterol, triglycerides, HDL-cholesterol, hemoglobin A1c, and adiponectin values were also evaluated.

Results: At the 12-month visit, BMD significantly increased in both groups. However, comparisons on changes of parameter values from baseline to the 12-month visit between the TRT and control groups were significantly different in BMD (5.0?±?5.0 vs. 3.0?±?3.2; p?=?.0434) and in adiponectin value (?0.90?±?3.33 vs. 0.10?±?2.04; p?=?.0192). There were no significant changes in other parameters.

Conclusions: TRT for 12 months could improve BMD with a decrease in adiponectin levels among hypogonadal men with osteopenia/osteoporosis.     

Community-Based System,Reports, and Substantiated Cases of Elder Abuse: Disparities Between Municipalities and Relating Factors in Japan

This study examines (1) the staffing and financial characteristics of systems for elder abuse detection and intervention in the municipal governments of Japan and (2) the relationship among the development of detection and intervention systems, the reporting rates of suspected elder abuse cases, and substantiated abuse rates in 927 municipalities across Japan. Progressive systems for the detection and intervention of elder abuse were significantly associated with a larger number of public officers than in non-progressive systems. Furthermore, greater rates of both suspected and substantiated cases of abuse were associated with progressive systems for elder abuse detection and intervention. Per capita annual expenditures on the comprehensive support project and the community general support center's catchment under the Long-Term Care Insurance (LTCI) program showed no significant association with the development of systems, the rate of suspected cases, or the number of substantiated cases. National social policy makers should examine strategies that would help municipalities assign sufficient staff to elder abuse detection and intervention programs.     

Systems Development and Difficulties in Implementing Procedures for Elder Abuse Prevention Among Private Community General Support Centers in Japan

The present study examines differences in systems development and difficulties in implementing procedures for elder abuse prevention in 1,119 private and 606 public community general support centers under the public long-term care insurance program in Japan. The private community general support centers showed more difficulty implementing procedures than the public community general support centers. Controlling for the type of municipality, progress in systems development did not differ between the private and public community general support centers. Further research should examine how the characteristics of municipal governments are related to systems development in community general support centers.     

The Importance of Freedom in the East and the West Over Time: A Meta-analytic Study of Predictors of Well-Being

We examined whether sense of freedom is an important predictor of well-being, as compared to other typical predictors, across different periods in modern times (1981–2011), and in the East and the West. We applied a meta-analytical approach to the results of a series of multiple regression analyses conducted on six individual waves of Japanese data sets and five individual waves of American data sets from the World Values Survey. The final sample comprised 6389 Japanese and 6176 American respondents during all study periods. The main findings were that sense of freedom was one of the strongest predictors of life satisfaction (a) among several predictors (i.e., health condition, household income, marital status), (b) consistently across waves, and (c) in both Japan and the United States, as typical collectivistic Eastern and individualistic Western countries. We conclude that the greater importance of sense of freedom in ensuring well-being than other typical predictors is applicable to individuals across time and cultures.     

Impact of additive covariate error on linear model

Abstract

We consider effect of additive covariate error on linear model in observational (radiation epidemiology) study for exposure risk. Additive dose error affects dose-response shape under general linear regression settings covering identity-link GLM type models and linear excess-relative-risk grouped-Poisson models. Under independent error, dose distribution that log of dose density is up to quadratic polynomial on an interval (the log-quadratic density condition), normal, exponential, and uniform distributions, is the condition for linear regression calibration. Violation of the condition can result low-dose-high-sensitivity model from linear no-threshold (LNT) model by the dose error. Power density is also considered. A published example is given.     

Effects of dutasteride on lower urinary tract symptoms: a prospective analysis based on changes in testosterone/dihydrotestosterone levels and total prostatic volume reduction

This study analyzed the effects of dutasteride on lower urinary tract symptoms based on the association between changes in the total testosterone (TT)/dihydrotestosterone (DHT) levels and total prostate volume (TPV) reduction. Sixty participants diagnosed with benign prostatic hyperplasia were given 0.5?mg of dutasteride daily for 52 weeks. Measures of TT and DHT levels, TPV and uroflowmetry were obtained before and after dutasteride treatment. Forty-three patients demonstrated a TPV reduction of ≥5% (Group 1), whereas the remaining 17 patients demonstrated a TPV reduction of <5% (Group 2). DHT suppression and DHT/TT ratio at baseline were significantly higher in Group 1 than Group 2. International Prostate Symptom Scores (IPSS) and uroflowmetry were significantly improved in both groups. In Group 2, nine patients demonstrated some improvement in IPSS (Group 2A), whereas eight did not (Group 2B). The rate of TT increase and improvement in voiding symptoms were significantly higher in Group 2A than Group 2B. Dutasteride-induced TPV reduction is dependent on individual 5-α reductase inhibitor activity. Some patients demonstrating smaller dutasteride-induced TPV reduction may experience an improvement in voiding symptoms owing to an increased level of testosterone.     

Estimation of two ordered normal means when a covariance matrix is known

Estimation of two normal means with an order restriction is considered when a covariance matrix is known. It is shown that restricted maximum likelihood estimator (MLE) stochastically dominates both estimators proposed by Hwang and Peddada [Confidence interval estimation subject to order restrictions. Ann Statist. 1994;22(1):67–93] and Peddada et al. [Estimation of order-restricted means from correlated data. Biometrika. 2005;92:703–715]. The estimators are also compared under the Pitman nearness criterion and it is shown that the MLE is closer to ordered means than the other two estimators. Estimation of linear functions of ordered means is also considered and a necessary and sufficient condition on the coefficients is given for the MLE to dominate the other estimators in terms of mean squared error.     

陆九渊哲学新考--陆九渊是否为“心学”思想家？

文章着眼于陆九渊谈及自身之心的不善，因此需要与他人切磋与读书之必要性，并以此分阐明其哲学非但未必是单纯的“心学”，甚至有着与朱熹之“理学”相类似的思想方向性。同时根据陆九渊文庥中书简排列的痕迹，推测出“陆王心学”这一认识亦是王守仁所活跃的明代正德年以后人为制造出的虚像。