Using In Vitro High‐Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards

Today there are more than 80,000 chemicals in commerce and the environment. The potential human health risks are unknown for the vast majority of these chemicals as they lack human health risk assessments, toxicity reference values, and risk screening values. We aim to use computational toxicology and quantitative high‐throughput screening (qHTS) technologies to fill these data gaps, and begin to prioritize these chemicals for additional assessment. In this pilot, we demonstrate how we were able to identify that benzo[k]fluoranthene may induce DNA damage and steatosis using qHTS data and two separate adverse outcome pathways (AOPs). We also demonstrate how bootstrap natural spline‐based meta‐regression can be used to integrate data across multiple assay replicates to generate a concentration–response curve. We used this analysis to calculate an in vitro point of departure of 0.751 μM and risk‐specific in vitro concentrations of 0.29 μM and 0.28 μM for 1:1,000 and 1:10,000 risk, respectively, for DNA damage. Based on the available evidence, and considering that only a single HSD17B4 assay is available, we have low overall confidence in the steatosis hazard identification. This case study suggests that coupling qHTS assays with AOPs and ontologies will facilitate hazard identification. Combining this with quantitative evidence integration methods, such as bootstrap meta‐regression, may allow risk assessors to identify points of departure and risk‐specific internal/in vitro concentrations. These results are sufficient to prioritize the chemicals; however, in the longer term we will need to estimate external doses for risk screening purposes, such as through margin of exposure methods.     

The influence of land use type and municipal context on urban tree species diversity

Recent research has focused on the ways urban forest patterns vary in relation to level of urbanization and socioeconomic characteristics, with most studies limited to one urban land use type or multiple non-differentiate land uses. Additionally, the majority of studies examining urban forest patterns focus on canopy cover extent, with less attention given to patterns of species diversity. This study explores how tree species diversity varies across different urban land uses and municipal boundaries to better understand the role of land use types in shaping urban forest patterns. The goal is addressed through an exploration of plot-level tree data in the urban municipalities of Peel Region located in the Greater Toronto Area (Ontario, Canada). Species composition and standard diversity metrics are calculated for eight land use types and four municipalities. Our results show that differences in diversity metrics and species composition are greater between urban land uses than municipalities. Moreover, Peel’s urban forest has relatively high alpha diversity but many species are present on only one land use type. The results suggest that different causal processes are associated with each land use type, and that urban forest managers should adopt land use-specific strategies to meet species composition goals within the urban forest.     

White Ethnic Diversity in Small Town Iowa: A Multilevel Analysis of Community Attachment

Community attachment is the feeling of being connected to community life. Within the community attachment literature, two classic approaches frame scholars’ understanding of this important dimension of community life: the linear development and systemic models. Our empirical models emphasize different factors for community attachment, including population size, density, and heterogeneity for the linear development model and age, length of residence, and social status for the systemic model. Surprisingly, heterogeneity has been omitted from analyses of the linear development model throughout the literature since its introduction, a shortcoming our study addresses. Though heterogeneity can be conceptualized in a number of ways, a large—and growing—body of literature focuses on the effects of race and ethnicity for communities. Here, we focus on a particular type of ethnic heterogeneity—European ancestry—and reincorporate this essential dimension of communities back into the linear development model of community attachment. Using data from the 2004 wave of the Iowa Community Survey and multilevel modeling techniques, we explore how white ethnic diversity matters for community life. We conclude with a discussion of the implications of our study, including potential avenues for future research focusing on other ethnicities that are often subsumed under broader racial and panethnic labels.     

Checkbooks in the Heartland: Change over Time in Voluntary Association Membership

Numerous scholars documented declines in America's social capital through the mid‐1990s but we do not know whether the trend has continued. Further, despite warnings by Robert Putnam and Theda Skocpol that the quality of Americans' voluntary association memberships has also deteriorated—moving from active, “face‐to‐face” memberships to passive, “checkbook” memberships—data have not been available to test this claim. In this article, we use both the Iowa Community Survey and the General Social Survey to explore the changing nature of voluntary association membership between 1994 and 2004. We demonstrate that not only are declines in voluntary association memberships continuing in the new century but there has been a shift in the intensity of voluntary association participation over time. We observe a decline in active membership over time and an increase in checkbook membership over time. These findings provide support for Putnam's claim that checkbook membership is increasing at the expense of more active types of memberships.     

Immigrants and Housing Markets in Mid-Size Metropolitan Areas1

The recent trend of immigrants arriving in mid-size metropolitan areas has received growing attention in the literature. This study examines the success of immigrants in the housing markets of a sample of 60 metropolitan areas using Census microdata in both 2000 and 2005. The results suggest that immigrants are less successful in achieving homeownership and more likely to live in overcrowded conditions than native-born whites of non-Hispanic origin. The immigrant effect on homeownership differs by geography and by immigrant group. Finally, we find evidence that immigrant networks increase the likelihood of becoming a homeowner.     

Insight into Informant Discrepancies Regarding Psychosexual Functioning of Adolescents with and without Autism Spectrum Disorder

The private nature of psychosexual functioning leads adolescents and their parents to have different perspectives, which highlights studying parent–child informant discrepancies in this domain. We investigated informant discrepancy in psychosexual functioning, using the self‐report and parent report versions of the Teen Transition Inventory (TTI), of adolescents with autism spectrum disorder (ASD; 136 parent–child dyads) compared to adolescents from the general population (GP; 70 parent–child dyads). Significantly larger informant discrepancies exist in ASD dyads than GP dyads in most domains of psychosexual functioning, except for Body image, Sexual behavior, and Confidence in the future. It is important to use and pay attention to both informants, as discrepancies are relevant for both research and clinical practice regarding psychosexual functioning.     

Walk-in Together: A pilot study of a walk-in online family therapy intervention

Many Australians are requiring mental health care, including families, leading to long wait times in order to access support. Walk-in therapy reduces barriers to mental health support services by providing support at the time that families seek help. This paper presents a proof-of-concept study investigating the acceptability and short-term effectiveness of an online walk-in family therapy service, Walk-in Together (WIT). Part 1 of the paper describes the experiences of 44 family members from 22 families who presented to a public family therapy clinic for a virtual walk-in family therapy session. The session was conducted by a team of three experienced family therapists. Family members' experiences were sought pre-session, post-session, and at 6 weeks follow-up via survey and interview. Part 2 of the paper explores therapist perceptions (n = 7) of the WIT approach, through thematic analysis of semi-structured interview data. Post-session feedback showed 85% of family members found WIT to be helpful and 50% were optimistic about their future as a family after their WIT session. Six weeks post-session it was revealed that WIT supported planning for families in equipping them to move forward with 88% of family members reporting that they knew what to do after the session. All therapists uniformly experienced the model as offering a timely and beneficial service, suitable for diverse presentations and constellations of families. These preliminary results suggest the significant utility of this WIT intervention as a well-received and helpful service for families, who valued the easy access and rapid therapeutic response afforded by the online, walk-in delivery model. This proof-of-concept paper suggests the potential for further development and growth of WIT, as well as other mental health support services using a walk-in, telehealth model to meet the rising demand for therapeutic support for families in distress.     

Improving the Mental Health Outcomes of LGBTQ Youth and Young Adults: A Longitudinal Study

ABSTRACT

The purpose of this groundbreaking study was to evaluate outcomes of 482 LGBTQ (lesbian, gay, bisexual, transgender, or questioning) youth and young adults who received services and supports through the Comprehensive Community Mental Health Services for Children with Serious Emotional Disturbances Program (CMHI). This study was a secondary data analysis using data from a larger study of 3208 LGBTQ and non-LGBTQ youth ages 11 through 21 who had a serious emotional disturbance (SED). This study is significant in that it evaluates functional outcomes for young people identified as LGBTQ based on a specialized service framework (i.e., system of care approach). In essence, do LGBTQ youth with SED benefit from a specific approach to intervention? In addition, a comparison at intake on suicidality, bullying and victimization was conducted between the LGBTQ and non-LGBTQ identifying youth from the larger sample. The youth and a caregiver were interviewed face-to-face separately at intake, 6-months, and 12-months. Significant improvements were found across all of the dependent variables, supporting the viability of SOC for improving outcomes for LGBTQ youth. Future research should continue to build on this study by adding to the design a control group to improve internal validity of the findings.