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In the development of many diseases there are often associated random variables which continuously reflect the progress of a subject towards the final expression of the disease (failure). At any given time these processes, which we call stochastic covariates, may provide information about the current hazard and the remaining time to failure. Likewise, in situations when the specific times of key prior events are not known, such as the time of onset of an occult tumour or the time of infection with HIV-1, it may be possible to identify a stochastic covariate which reveals, indirectly, when the event of interest occurred. The analysis of carcinogenicity trials which involve occult tumours is usually based on the time of death or sacrifice and an indicator of tumour presence for each animal in the experiment. However, the size of an occult tumour observed at the endpoint represents data concerning tumour development which may convey additional information concerning both the tumour incidence rate and the rate of death to which tumour-bearing animals are subject. We develop a stochastic model for tumour growth and suggest different ways in which the effect of this growth on the hazard of failure might be modelled. Using a combined model for tumour growth and additive competing risks of death, we show that if this tumour size information is used, assumptions concerning tumour lethality, the context of observation or multiple sacrifice times are no longer necessary in order to estimate the tumour incidence rate. Parametric estimation based on the method of maximum likelihood is outlined and is applied to simulated data from the combined model. The results of this limited study confirm that use of the stochastic covariate tumour size results in more precise estimation of the incidence rate for occult tumours.  相似文献   
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Working with a treatment and observing team at the same time, behind the oneway mirror, offers a variety of ways to: (a) generate multiple realities; (b) work with two different models of family therapy simultaneously; and (c) provide feedback on the teams' own roles, rules and group process. The process that 6 trainees and two supervisors used with T and O teams to examine their own coevolution as a therapeutic system using the Milan model of family therapy and Ericksonian hypnotherapy is described. The article concludes with a discussion of the advantages and pitfalls of this type of dual supervision.  相似文献   
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Recent evidence has emerged that in Britain, like the US, many children below the official minimum school leaving age, are working. In many cases, the work is illegal. Research in the US suggests that many working children risk accidents and other hazards to health. Evidence from Britain on the health and safety aspects of child labour is of a more fragmentary nature, but enough exists to suggest a need for greater vigilance.  相似文献   
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Matthews CM 《Social action》1979,29(2):115-149
This paper reports the findings of 2 studies in North Arcot District of Tamil Nadu, one of which was an evaluation of health education programs. A wide range of information is made available on the local Tamil names for allopathic diseases, their etiology, beliefs related to preventive and curative practices, significance and medical consequences of recourse to doctors and practitioners of indigenous systems of medicine. The attitude survey covers a variety of topics about which not much is known -- immunization, sanitation, environment, antenatal care and allopathic medicine. The data suggest that allopathic treatment is preferred for most diseases, although traditional or spiritual methods continue to be used for certain diseases, many of which are believed to be the cause of infant and child mortality.  相似文献   
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There are increasing numbers of families in Australia headed by sole parents, but little is known about the experiences of those who also care for a child with a disability. Additional caring responsibilities have previously been shown to impact on the work participation of parents. This study involved qualitative analyses of interview data conducted with sole mothers with school‐aged children with disability (N = 11). Thematic analysis revealed four themes that enabled and supported participation in the workforce: social support; managing appointments; characteristics of the workplace; and the role of the school. Results suggest the importance of practical help from family and friends in facilitating participation in paid employment. Additionally, the importance of flexible appointment scheduling on the part of service providers was highlighted, as well as the importance of workplace flexibility and supportive workplace cultures. Such factors were important in supporting sole mothers to balance work with care, with important implications for personal and family wellbeing.  相似文献   
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Following the UK’s EU referendum in June 2016, there has been considerable interest from scholars in understanding the characteristics that differentiate Leave supporters from Remain supporters. Since Leave supporters score higher on conscientiousness but lower on neuroticism and openness, and given their general proclivity toward conservatism, we hypothesized that preference for realistic art would predict support for Brexit. Data on a large nationally representative sample of the British population were obtained, and preference for realistic art was measured using a four‐item binary choice test. Controlling for a range of personal characteristics, we found that respondents who preferred all four realistic paintings were 15–20 percentage points more likely to support Leave than those who preferred zero or one realistic paintings. This effect was comparable to the difference in support between those with a degree and those with no education, and was robust to controlling for the respondent’s party identity.  相似文献   
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Rice  Lindsay  Greenlee  Eric T. 《Gender Issues》2019,36(2):136-151
Gender Issues - Research examining gender disparities in the workplace tends to focus on individual behavior rather than the behavior of teams or dyads, yet important workplace decisions such as...  相似文献   
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