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1.
Stephen J. Ruberg Frank E. Harrell Jr. Margaret Gamalo-Siebers Lisa LaVange J. Jack Lee Karen Price 《The American statistician》2019,73(1):319-327
ABSTRACTThe cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making. 相似文献
2.
After reviewing the debate about public sociologies in the American Sociological Association over the past few years, we offer
a response to calls for “saving sociology” from the Burawoy approach as well as an analytic critique of the former ASA president's
“For Public Sociology” address. While being sympathetic to the basic idea of public sociologies, we argue that the “reflexive”
and “critical” categories of sociology, as Burawoy has conceptualized them, are too ambiguous and value-laden to allow for
empirical investigation of the different major orientations of sociological research and the ways the discipline can address
non-academic audiences. Debates about the future of sociology should be undertaken with empirical evidence, and we need a
theoretical approach that can allow us to compare both disciplines and nations as well as taking into account the institutional
context of the universities in which we operate. Research into the conditions under which professional, critical, policy,
and public sociologies could work together for the larger disciplinary and societal good is called for instead of overheated
rhetoric both for and against public sociologies. 相似文献
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According to traditional error theory, sentiment measurements vary unsystematically from individual to individual. However, we find some patterned deviation in sentiments that characterize subsets of respondents within a seemingly homogeneous population. After demonstrating the existence of such patterns, we report an exploratory study aimed at identifying social characteristics of people with different patterns of sentiments. People embedded in multiple social networks have exaggerated sentiments that contour cultural patterns, and people with few social associations have attenuated sentiments conveying cultural detachment. In addition, people with disciplinary parents and romantic privation have some distinctive sentiments, depending on their gender. 相似文献
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Lisa A. Gennetian Greg Duncan Virginia Knox Wanda Vargas Elizabeth Clark‐Kauffman Andrew S. London 《Journal of research on adolescence》2004,14(4):399-423
Using data from 8 random assignment studies and employing meta‐analytic techniques, this article provides systematic evidence that welfare and work policies targeted at low‐income parents have small adverse effects on some school outcomes among adolescents ages 12 to 18 years at follow‐up. These adverse effects were observed mostly for school performance outcomes and occurred in programs that required mothers to work or participate in employment‐related activities and those that encouraged mothers to work voluntarily. The most pronounced negative effects on school outcomes occurred for the group of adolescents who had a younger sibling, possibly because of the increased home and sibling care responsibilities they assumed as their mothers increased their employment. 相似文献
8.
Stolzenberg Lisa D'Alessio Stewart J. Rivers James E. Newell Augusto L. 《Social indicators research》2003,61(1):19-57
Determining the size and demographiccharacteristics of substance abuse populationsis extremely important for implementing publicpolicies aimed at the control of substanceabuse. Such information not only assists in theallocation of limited treatment resources bythe state, but also in the monitoring ofsubstance abuse trends over time and in theevaluation of innovative policy initiatives. Inthis study, we develop three composite measuresof treatment need. We then use these measuresto estimate treatment need for alcohol abuseand for controlled substance abuse within eachof Florida's 67 counties. This study providesan important empirical component of communityplanning, quantifying and, to a limited degree,specifying the level of need for the substanceabuse treatment of community residents. Anadditional benefit is the development of a costeffective and unobtrusive methodology fordetermining empirically when levels of need arechanging so that treatment levels can beadjusted accordingly. With proper use,policymakers can readily employ the methodologydeveloped in this study in Florida andelsewhere to make better-informed decisions inthe allocation of finite substance abusetreatment resources. 相似文献
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Lisa Vanhala 《Disability & Society》2006,21(5):551-565
The enactment of British and European legislation establishing rights for disabled people is an important step in combating discrimination and social exclusion. However, rights remain empty promises if they are not enforced. Litigation and test case strategies have become an important way of enforcing rights. This article explores why organizations might turn to the courts to achieve their policy goals and finds that this phenomenon is best explained not by the creation of legal bases or an expanding legal opportunity structure but rather by the adoption of the social, civil-rights model of disability by the disability movement. The social model, with its emphasis on individual rights, equality and reasonable accommodation laid the foundation for litigation strategies. Litigation is able to reduce exclusion through long-term socialization of norms of equality and through the short- and medium-term creation of incentives which encourage individuals to end discriminatory practices. 相似文献