Proteins' promise--progress and challenges in ovarian cancer proteomics

Ovarian cancer is the leading cause of gynaecological cancer death. The mortality rate of ovarian cancer could be greatly decreased if there were a screening test which was able to detect the disease at an early stage, resulting in an increased probability of cure. The most promising prospect for the early detection of ovarian cancer comes from the rapidly advancing field of clinical proteomics. An increasing number of reports on the potential clinical application of proteomics research for early detection as well as risk assessment and management of ovarian cancer are being published. Although the research is very promising, major technical challenges are still preventing new discoveries in ovarian cancer proteomics from being translated into clinical practice.     

Die Rolle des Luftverkehrsrechts und der Haftung bei Flugzeugkatastrophen: Eine Finanzmarktanalyse

Zusammenfassung  Rechtsansprüche gegen Fluggesellschaften und Flugzeughersteller in Folge einer Flugzeugkatastrophe richten sich nach einer Flut rechtlicher Bestimmungen, die aus internationalen Abkommen, Vereinbarungen zwischen Fluglinien sowie aus Bundes- und Landesrecht resultieren. Die jeweilige Rechtsgrundlage in einem spezifischen Fall h?ngt von verschiedenen Umst?nden ab, die mit einem Unfall verbunden sind. Es überrascht daher nicht, dass zugesprochene Schadensersatz- und Schmerzensgeldzahlungen an die Angeh?rigen der Opfer von Fall zu Fall erheblich divergieren. In unserer Studie mit U.S.-amerikanischen Daten untersuchen wir, inwieweit der kurz- und langfristige Erfolg von Fluggesellschaften und Flugzeugherstellern durch Flugzeugkatastrophen beeinflusst wird und wir eruieren diejenigen Determinanten, die Performanceunterschiede erkl?ren k?nnen. Verwandte Untersuchungen haben sich weitgehend auf Effekte für Markennamen oder steigende Versicherungspr?mien als Ursachen für Aktienkursverluste konzentriert. Unsere Ergebnisse zeigen darüber hinaus, dass das regulatorische Umfeld einer spezifischen Unglückssituation erheblichen Einfluss darauf hat, wie Finanzm?rkte reagieren. Die Reaktionen der Marktteilnehmer weisen darauf hin, dass die unterschiedlichen Berechnungsgrundlagen für die Opferentsch?digung recht klar erkannt werden.

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The role of aviation laws and legal liability in airplane accidents: A financial market perspective

Summary  Legal liability claims against airlines and airplane manufacturers following an aviation disaster are determined through a myriad of international treaties, intercarrier agreements, and federal and state laws. Which law applies in a specific situation depends on various circumstances surrounding the accident. As a result, pecuniary and non-pecuniary damage awards for the families of the accident victims may vary substantially from case to case. Using U.S. data, our study examines how aviation disasters affect the short and long-term performance of airlines and airplane manufacturers and explores the factors that drive the performance differences. While prior research has largely focused on brand name effects and rising insurance premiums as possible determinants of stock price losses, our results suggest that the regulatory environment that applies to a given aviation accident has a significant impact on how the market reacts to its announcement. Inequities in the valuation of a human life are clearly reflected in stock price reactions. While recent regime changes have helped eliminate some of these imbalances further reform may be necessary.

     

Schließung von Schulen — Chancen für schulische Innovationsprozesse

Closing down schools — chances of scholar innovative processes. Coaching as support of merging processesThe author discusses chances and risks of processes of school merging processes as an internal coach of a school board. Conditions for success are named for various levels of hierarchy in the school system. This includes an support by means of coaching and supervision.     

Multi-objective allocation: A data-free approach

In urban planning and other fields a number of apparently different problems have two features in common. First, a fixed total of a resource is to be split among several claimants. Second, different interested parties have differing views as to what constitutes an optimum allocation. We present methods for the quantification of preferences and for the production of a compromise optimum. The methods have the merit of being problem independent and sparing in their demands for data and for specialised computer software.     

Principles for Developing Benchmark Criteria for Staff Training in Responsible Gambling

One approach to minimizing the negative consequences of excessive gambling is staff training to reduce the rate of the development of new cases of harm or disorder within their customers. The primary goal of the present study was to assess suitable benchmark criteria for the training of gambling employees at casinos and lottery retailers. The study utilised the Delphi Method, a survey with one qualitative and two quantitative phases. A total of 21 invited international experts in the responsible gambling field participated in all three phases. A total of 75 performance indicators were outlined and assigned to six categories: (1) criteria of content, (2) modelling, (3) qualification of trainer, (4) framework conditions, (5) sustainability and (6) statistical indicators. Nine of the 75 indicators were rated as very important by 90 % or more of the experts. Unanimous support for importance was given to indicators such as (1) comprehensibility and (2) concrete action-guidance for handling with problem gamblers, Additionally, the study examined the implementation of benchmarking, when it should be conducted, and who should be responsible. Results indicated that benchmarking should be conducted every 1–2 years regularly and that one institution should be clearly defined and primarily responsible for benchmarking. The results of the present study provide the basis for developing a benchmarking for staff training in responsible gambling.