TEACHING THE PRODUCTION/OPERATIONS MANAGEMENT CORE COURSE: INTEGRATING LOGISTICS PLANNING ACTIVITIES

This paper discusses the benefits of restructuring the introductory undergraduate production and operations management (pom) course to improve its pedagogical effectiveness and to better convey the importance of integrating logistics planning activities. The introduction of a dynamic integrative semester-long case study which involves students in applying pom concepts and tools through a simulation game is reported.     

Do participation rates change when active consent procedures replace passive consent

Researchers face considerable ambiguity and controversy regarding the issue of informed consent. Decisions about consent procedures can affect study participation rates and prevalence estimates among specific populations. Changing from passive to active parental consent procedures was examined in a case study with an anonymous survey of sixth- through eighth-grade students' substance use. Four types of procedures for obtaining parental consent were examined. Results suggest that certain types of consent procedures can yield high levels of participation. This study also demonstrates that low participation rates with some active consent procedures can cause biases in sample characteristics and outcome data.     

Do fines for violating possession-use-purchase laws reduce youth tobacco use?

The present brief report followed children exposed to consequences for violating Purchase, Use, and Possession (PUP) laws over time to assess changes in their smoking status. Youth in 24 towns were surveyed once a year for 3 years, and rates of tobacco use for those fined for PUP law violations were assessed. Of those who were given a ticket for a PUP law violation, 35 (39%) reported not smoking during year 1. Students in grade 7 were more likely to have quit smoking (84%) than those in grade 8 (35%), grade 9 (32%), or grade 10 (21%). For the two follow-up years, 45% and 41% reported not smoking. Assuming those who attrited were smokers, it is possible that about 15% to 24% of the original sample of children cited actually quit smoking over the follow-up period. The implications of these findings are discussed.     

The dynamics of hapū research relationships

Abstract

The Whakaki Lake Trust has a long history of being an active kaitiaki of Whakaki Lake and has developed a hapū-based restoration and enhancement programme at the Lake property. Part of this programme has involved working with a range of external agencies and researchers. Research relationships have become an important part of the restoration process to build the capability and capacity of hapū to execute activities associated with restoration. In addition, relationships have provided an opportunity to strengthen and expand the knowledge base that hapū can draw upon to inform ecological restoration and resource management decisions. Some of these relationships have been adversarial and a source of much frustration. As a consequence the Trust has developed very clear expectations and policy around working with others. My experience of developing a doctoral research project with Whakaki Lake Trust is used here to discuss hapū expectations of research and resultant academic dilemmas.     

Penalized Maximum Likelihood Estimator for Normal Mixtures

The estimation of the parameters of a mixture of Gaussian densities is considered, within the framework of maximum likelihood. Due to unboundedness of the likelihood function, the maximum likelihood estimator fails to exist. We adopt a solution to likelihood function degeneracy which consists in penalizing the likelihood function. The resulting penalized likelihood function is then bounded over the parameter space and the existence of the penalized maximum likelihood estimator is granted. As original contribution we provide asymptotic properties, and in particular a consistency proof, for the penalized maximum likelihood estimator. Numerical examples are provided in the finite data case, showing the performances of the penalized estimator compared to the standard one.     

中国古代慈善事业的发展特点

中国古代慈善事业在漫长的历史发展过程中不但逐渐形成了庞杂而丰富的思想体系,而且其慈善主体也实现了从最初单纯的国家慈善到以国家慈善为主、宗族慈善和宗教慈善为重要补充的多元化发展过程。另外,中国古代慈善事业的发展轨迹还明显具备与整个中国古代社会兴衰相表里的重要特点。     

Sexually Transmitted Infections and Unintended Pregnancy: A Longitudinal Analysis of Risk Transmission Through Friends and Attitudes

Data from 1,087 adolescent participants in three waves of the National Longitudinal Study of Adolescent Health were used to examine the effects of peer selection and socialization processes in adolescence on later reports of sexually transmitted infections (STI) and unintended pregnancies. Friends' attitudes and behavior were assessed with friends' reports. Among male adolescents, there was evidence for selection effects on STI diagnoses and socialization effects on reports of unintended pregnancy, both involving friends' attitudes. Among female adolescents, there was evidence for long‐term effects of both socialization and selection processes involving same‐sex friends' attitudes. Discussion focuses on the importance of peer and individual attitudes as potential intervention targets.     

Combination of Cancer Data in Quantitative Risk Assessments: Case Study Using Bromodichloromethane

There are often several data sets that may be used in developing a quantitative risk estimate for a carcinogen. These estimates are usually based, however, on the dose-response data for tumor incidences from a single sex/strain/species of animal. When appropriate, the use of more data should result in a higher level of confidence in the risk estimate. The decision to use more than one data set (e.g., representing different animal sexes, strains, species, or tumor sites) can be made following biological and statistical analyses of the compatibility of these data sets. Biological analysis involves consideration of factors such as the relevance of the animal models, study design and execution, dose selection and route of administration, the mechanism of action of the agent, its pharmacokinetics, any species- and/or sex-specific effects, and tumor site specificity. If the biological analysis does not prohibit combining data sets, statistical compatibility of the data sets is then investigated. A generalized likelihood ratio test is proposed for determining the compatibility of different data sets with respect to a common dose-response model, such as the linearized multistage model. The biological and statistical factors influencing the decision to combine data sets are described, followed by a case study of bromodichloromethane.     

Methods and Rationale for Derivation of a Reference Dose for Methylmercury by the U.S. EPA

In 2001, the U.S. Environmental Protection Agency derived a reference dose (RfD) for methylmercury, which is a daily intake that is likely to be without appreciable risk of deleterious effects during a lifetime. This derivation used a series of benchmark dose (BMD) analyses provided by a National Research Council (NRC) panel convened to assess the health effects of methylmercury. Analyses were performed for a number of endpoints from three large longitudinal cohort studies of the neuropsychological consequences of in utero exposure to methylmercury: the Faroe Islands, Seychelles Islands, and New Zealand studies. Adverse effects were identified in the Faroe Islands and New Zealand studies, but not in the Seychelles Islands. The NRC also performed an integrative analysis of all three studies. The EPA applied a total uncertainty factor (UF) of 10 for intrahuman toxicokinetic and toxicodynamic variability and uncertainty. Dose conversion from cord blood mercury concentrations to maternal methylmercury intake was performed using a one-compartment model. Derivation of potential RfDs from a number of endpoints from the Faroe Islands study converged on 0.1 microg/kg/day, as did the integrative analysis of all three studies. EPA identified several areas for which further information or analyses is needed. Perhaps the most immediately relevant is the ratio of cord:maternal blood mercury concentration, as well as the variability around this ratio. EPA assumed in its dose conversion that the ratio was 1.0; however, available data suggest it is perhaps 1.5-2.0. Verification of a deviation from unity presumably would be translated directly into comparable reduction in the RfD. Other areas that EPA identified as significant areas requiring further attention are cardiovascular consequences of methylmercury exposure and delayed neurotoxicity during aging as a result of previous developmental or adult exposure.     

Non-parametric Quantile Regression with Censored Data

Abstract.  Censored regression models have received a great deal of attention in both the theoretical and applied statistics literature. Here, we consider a model in which the response variable is censored but not the covariates. We propose a new estimator of the conditional quantiles based on the local linear method, and give an algorithm for its numerical implementation. We study its asymptotic properties and evaluate its performance on simulated data sets.