Sample sizes for estimation in clinical research

A sample size justification should be given for all clinical investigations. However, sometimes the objective of a trial is to estimate an effect with a view to planning a later definitive study. This paper describes the calculations for designing studies where one wishes to adopt an estimation approach through using confidence intervals around the overall response. Calculations are given for data anticipated to take a Normal form. Copyright © 2004 John Wiley & Sons, Ltd.     

Pen Dudley''s name finally disappears from the public relations marquee

When the public relations firm D-A-Y was dissolved into Ogilvy & Mather Public Relations November 1, 1988, the longest lived public relations agency disappeared into the sands of time that enveloped the first four agencies started in the first decade of the waning century. The D in D-A-Y stood for Pendleton Dudley, a venerable pioneer in this vocation, who had opened his agency in Wall Street in 1909 at the urging of his good friend, Ivy Lee. Dudley, a rugged, independent product of frontier America, headed his firm for fifty-seven years—a longevity record surpassed only by that of Edward L. Bernays, who started his firm in 1919 in the Post World War I public relations boom.Pendleton Dudley—known to his close friends as Pen and to his associates in his firm as PD, was born September 8, 1876, in a small frontier town of Troy, Missouri, when America was an agricultural nation. He came to pioneer as a counselor to the corporate giants, AT&T among them, in a complex, interdependent corporate industrial America. Pen Dudley did much to infuse this field with respectability in a time when it was viewed with suspicion or disdain in its early years. He was a strong advocate of research as the only sound basis for planning and executing programs to influence public behavior. He was also active in the Public Relations Society of America after it was formed in 1948 and was in the forefront of those creating the now extinct Foundation for Public Relations Research and Education. In 1965, he received the Distinguished Service Award from the New York PRSA Chapter. He died at the age of 90 in 1966.The author is Dean Emeritus of Journalism at the University of Georgia, and co-author Effective Public Relations, 6th Ed.     

An individual measure of relative survival

Summary.  Relative survival techniques are used to compare survival experience in a study cohort with that expected if background population rates apply. The techniques are especially useful when cause-specific death information is not accurate or not available as they provide a measure of excess mortality in a group of patients with a certain disease. Whereas these methods are based on group comparisons, we present here a transformation approach which instead gives for each individual an outcome measure relative to the appropriate background population. The new outcome measure is easily interpreted and can be analysed by using standard survival analysis techniques. It provides additional information on relative survival and gives new options in regression analysis. For example, one can estimate the proportion of patients who survived longer than a given percentile of the respective general population or compare survival experience of individuals while accounting for the population differences. The regression models for the new outcome measure are different from existing models, thus providing new possibilities in analysing relative survival data. One distinctive feature of our approach is that we adjust for expected survival before modelling. The paper is motivated by a study into the survival of patients after acute myocardial infarction.     

SOCIOECONOMIC STATUS, JOB CONDITIONS, AND WELL-BEING: Self-Concept Explanations for Gender-Contingent Effects

Using data from a representative sample of adults age eighteen to fifty‐five who reside in Toronto, Canada, and are employed in the paid labor force, this study asks: Are the health benefits of education, income, job autonomy, and nonroutinized work different for women and men? If so, do mastery and self‐esteem contribute to those differences? Results show that women and men derive different personal benefits from socioeconomic status and job qualities: (1) education, job autonomy, and nonroutinized work are associated more positively with the sense of mastery among women, (2) job autonomy is associated more positively with self‐esteem among women, (3) education, job autonomy, and nonroutinized work are associated more negatively with depressive symptoms among women, and (4) job autonomy and nonroutinized work are associated more positively with global health among women. Moreover, the patterns in (1) and (2) explain the gender‐contingent effects in (3) and (4). In addition, unexpected suppression effects reveal that, among men, education is associated negatively with mastery and self‐esteem—but only after adjustment for job conditions. I interpret the findings in the context of the disadvantaged status thesis and speculate about status‐related social comparison processes.     

Classifying At‐Risk High School Youth: The Influence of Exposure to Community Violence and Protective Factors on Academic and Health Outcomes

Using cluster analysis, 789 predominately Latino and African American high school youth were classified into varying academic at‐risk profiles using self‐reported levels of academic confidence, motivation to attend school, perceived family support, connections with teachers and peers, and exposure to violence. Six clusters emerged, 5 of which were identified as “at‐risk.” The clusters were examined in relation to academic stress, health status, grades, and school retention. Exposure to violence was one distinguishing feature of youth identified as most vulnerable, vulnerable, and resilient; however, youth identified as resilient recorded better academic outcomes.     

A Process for Incorporating Comparative Risk into Environmental Policymaking in Louisiana

The goal of Louisiana's 1990–1991 comparative risk project, also called the Louisiana Environmental Action Plan (LEAP), was to incorporate risk assessment into state environmental planning and policymaking. Scientists, government officials, and citizens were brought together to estimate the relative risk to human health, natural resources, and quality of life posed by 33 selected environmental issues. The issues were then ranked according to their relative estimated risks. It was hoped that this ranking of "comparative risks" would enable state policymakers to target the most important environmental problems and allocate scarce public resources more rationally and efficiently. As a result of the project, the governor issued an Executive Order forming a permanent Public Advisory Committee to continue this type of comparative risk assessment in Louisiana.