Exposure Reconstruction for the TCDD-Exposed NIOSH Cohort Using a Concentration- and Age-Dependent Model of Elimination

Recent studies demonstrating a concentration dependence of elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suggest that previous estimates of exposure for occupationally exposed cohorts may have underestimated actual exposure, resulting in a potential overestimate of the carcinogenic potency of TCDD in humans based on the mortality data for these cohorts. Using a database on U.S. chemical manufacturing workers potentially exposed to TCDD compiled by the National Institute for Occupational Safety and Health (NIOSH), we evaluated the impact of using a concentration- and age-dependent elimination model (CADM) (Aylward et al., 2005) on estimates of serum lipid area under the curve (AUC) for the NIOSH cohort. These data were used previously by Steenland et al. (2001) in combination with a first-order elimination model with an 8.7-year half-life to estimate cumulative serum lipid concentration (equivalent to AUC) for these workers for use in cancer dose-response assessment. Serum lipid TCDD measurements taken in 1988 for a subset of the cohort were combined with the NIOSH job exposure matrix and work histories to estimate dose rates per unit of exposure score. We evaluated the effect of choices in regression model (regression on untransformed vs. ln-transformed data and inclusion of a nonzero regression intercept) as well as the impact of choices of elimination models and parameters on estimated AUCs for the cohort. Central estimates for dose rate parameters derived from the serum-sampled subcohort were applied with the elimination models to time-specific exposure scores for the entire cohort to generate AUC estimates for all cohort members. Use of the CADM resulted in improved model fits to the serum sampling data compared to the first-order models. Dose rates varied by a factor of 50 among different combinations of elimination model, parameter sets, and regression models. Use of a CADM results in increases of up to five-fold in AUC estimates for the more highly exposed members of the cohort compared to estimates obtained using the first-order model with 8.7-year half-life. This degree of variation in the AUC estimates for this cohort would affect substantially the cancer potency estimates derived from the mortality data from this cohort. Such variability and uncertainty in the reconstructed serum lipid AUC estimates for this cohort, depending on elimination model, parameter set, and regression model, have not been described previously and are critical components in evaluating the dose-response data from the occupationally exposed populations.     

The Precautionary Principle Versus Risk Analysis

Precautionary behavior serves a valuable protective purpose as a first response to the new. It causes a quick retreat to the safety of the familiar; it provides time for a realistic "friend or foe" assessment of a new event. This rational assessment is often delayed by the sluggishness of government bureaucratic processes, or stopped by an implied challenge to a status quo. At the public level, reassurance may be slow to overcome an early uncertainty. However, a precautionary response does not provide an operational governing principle, although it makes publicly plausible an indefinite concealment of de facto political actions, or nonaction. The alternative of rational decision making at the policy level should flow from a comparative benefit/cost/risk analysis. Such early risk analyses have pragmatic uncertainties based on the limited available knowledge base and, accordingly, require judgmental application.     

Hypothetical Fears and Quantitative Risk Analysis

Hypothetical fears are concepts, not quantities. Their conceptual nature makes impractical conventional quantitative risk analyses (QRA) based on benefit/cost/risk, so they become an unmeasured influence in national decision making. The decision process involves two steps, the Analytic Stage (QRA based) and the Priority Stage (resource allocation competition). This article suggests that a quantitative estimate of the social cost of fear reduction to acceptable levels be used as a surrogate QRA input to the Priority Stage.     

Disaster Management from a POM Perspective: Mapping a New Domain

We have reviewed disaster management research papers published in major operations management, management science, operations research, supply chain management and transportation/logistics journals. In reviewing these studies, our objective is to assess and present the macro level “architectural blue print” of disaster management research with the hope that it will attract new researchers and motivate established researchers to contribute to this important field. The secondary objective is to bring this disaster research to the attention of disaster administrators so that disasters are managed more efficiently and more effectively. We have mapped the disaster management research on the following five attributes of a disaster: (1) Disaster Management Function (decision‐making process, prevention and mitigation, evacuation, humanitarian logistics, casualty management, and recovery and restoration), (2) Time of Disaster (before, during and after), (3) Type of Disaster (accidents, earthquakes, floods, hurricanes, landslides, terrorism and wildfires etc.), (4) Data Type (Field and Archival data, Real data and Hypothetical data), and (5) Data Analysis Technique (bidding models, decision analysis, expert systems, fuzzy system analysis, game theory, heuristics, mathematical programming, network flow models, queueing theory, simulation and statistical analysis). We have done cross tabulations of data among these five parameters to gain greater insights into disaster research. Recommendations for future research are provided.     

After the highwayman: Syntax and successful placement of press releases in newspapers

This study proves once again that too many press releases are poorly written and over-written, with long sentences and paragraphs, and poor syntax as well as weak and passive construction. In their use of press releases, journalists almost always have to make them simpler, shorter, easier to read, and less passive.The authors conclude that success in writing of press releases requires brevity and simplicity, shorter paragraphs, sentences, and words, and the elimination of the passive voice.Timothy Walters is an assistant professor of communication at Stephen F. Austin State University in Nacogdoches, TX. Lynne Walters is associate professor of journalism and Douglas Starr professor of journalism, both at Texas A&M University, College Station. Lynne Walters is currently a Fulbright professor at the American Journalism Center in Budapest, where her husband Timothy is also on a one-year appointment as a visiting professor.