Restricted mean survival time as a summary measure of time‐to‐event outcome

Many clinical research studies evaluate a time‐to‐event outcome, illustrate survival functions, and conventionally report estimated hazard ratios to express the magnitude of the treatment effect when comparing between groups. However, it may not be straightforward to interpret the hazard ratio clinically and statistically when the proportional hazards assumption is invalid. In some recent papers published in clinical journals, the use of restricted mean survival time (RMST) or τ ‐year mean survival time is discussed as one of the alternative summary measures for the time‐to‐event outcome. The RMST is defined as the expected value of time to event limited to a specific time point corresponding to the area under the survival curve up to the specific time point. This article summarizes the necessary information to conduct statistical analysis using the RMST, including the definition and statistical properties of the RMST, adjusted analysis methods, sample size calculation, information fraction for the RMST difference, and clinical and statistical meaning and interpretation. Additionally, we discuss how to set the specific time point to define the RMST from two main points of view. We also provide developed SAS codes to determine the sample size required to detect an expected RMST difference with appropriate power and reconstruct individual survival data to estimate an RMST reference value from a reported survival curve.     

Community-Based System,Reports, and Substantiated Cases of Elder Abuse: Disparities Between Municipalities and Relating Factors in Japan

This study examines (1) the staffing and financial characteristics of systems for elder abuse detection and intervention in the municipal governments of Japan and (2) the relationship among the development of detection and intervention systems, the reporting rates of suspected elder abuse cases, and substantiated abuse rates in 927 municipalities across Japan. Progressive systems for the detection and intervention of elder abuse were significantly associated with a larger number of public officers than in non-progressive systems. Furthermore, greater rates of both suspected and substantiated cases of abuse were associated with progressive systems for elder abuse detection and intervention. Per capita annual expenditures on the comprehensive support project and the community general support center's catchment under the Long-Term Care Insurance (LTCI) program showed no significant association with the development of systems, the rate of suspected cases, or the number of substantiated cases. National social policy makers should examine strategies that would help municipalities assign sufficient staff to elder abuse detection and intervention programs.     

Is more health always better for society? Exploring public preferences that violate monotonicity

There has recently been some literature on the properties of a Health-Related Social Welfare Function (HRSWF). The aim of this article is to contribute to the analysis of the different properties of a HRSWF, paying particular attention to the monotonicity principle. For monotonicity to be fulfilled, any increase in individual health—other things equal—should result in an increase in social welfare. We elicit public preferences concerning trade-offs between the total level of health (concern for efficiency) and its distribution (concern for equality), under different hypothetical scenarios through face-to-face interviews. Of key interests are: the distinction between non-monotonic preferences and Rawlsian preferences; symmetry of HRSWF; and the extent of inequality neutral preferences. The results indicate strong support for non-monotonic preferences, over Rawlsian preferences. Furthermore, the majority of those surveyed had preferences that were consistent with a symmetric and inequality averse HRSWF.     

A Study of the Properties of the Item Count Technique

The item count technique is an indirect questioning techniquethat is used to estimate the proportion of people who have engagedin stigmatizing behavior. This technique is expected to yielda more appropriate estimate than the ordinary direct questioningtechnique because it requests respondents to indicate, basedon a list of several items, simply the number of items thatare applicable to them, including the target key item. An experimentalweb survey was conducted in an attempt to compare the directquestioning technique and the item count technique. Comparedwith the direct questioning technique, the item count techniqueyielded higher estimates of the proportion of shoplifters bynearly 10 percentage points, whereas the difference betweenthe estimates using these two techniques was mostly insignificantwith respect to innocuous blood donation. The survey resultssuggest that in the item count technique respondents tend toreport fewer total behaviors compared to the direct questioncase. This tendency is more pronounced in the case of longeritem lists. Three domain estimators for the item count techniquewere compared, and the cross-based method appeared to be themost appropriate method. Large differences in domain estimatesfor shoplifting between the item count and direct questioningtechniques were found among female respondents, middle-agedrespondents, respondents living in urban areas, and highly-educatedrespondents.     

Japanese Fathers of Preschoolers and Their Involvement in Child Care

We examine how relative resources, time availability, gender ideology, living arrangement, child‐care demand, and job satisfaction are associated with the levels of younger Japanese fathers’ involvement in child care for preschoolers. A theoretical model that includes these factors is tested using 1994 data collected from Japanese fathers and mothers with preschool children (N = 442 couples). We find that practical considerations such as fathers’ shorter work hours, mothers’ full‐time employment, fewer adults and more children in households, and younger ages of children are associated with higher levels of paternal involvement. Implications of these findings are discussed in light of attention to ways to encourage Japanese men's sharing of child‐care responsibilities with their wives.     

General saddlepoint approximations and normalizing transformations for multivariate statistics

The use of general saddlepoint approximations is investigated for the problem of approximating the tail probabilities of statistics in multivariate analysis. A method based on normalizing transformations is proposed to prevent po¬tential deficiencies in general saddlepoint approximations. The efficiency of the proposed method is illustrated through examples of the sample correlation     

禅宗公案的形成和公案禅的起源

禅宗公案是在漫长的历史过程中逐渐形成的。本文通过分析举话活动的源流、公案集的出现以及拈颂对公案形成所起的作用,来讨论禅宗公案的形成过程。实际上,公案是在宋代禅师阐释唐代禅师言行的过程中形成的。公案的形成为公案禅的产生准备了条件。     

General saddlepoint approximations to distributions under an elliptical population

General saddlepoint approximations are derived for the distributions of statistics under an elliptical population. The technique is applied to obtain the tail probabilities of latent roots of a sample covariance matrix. It is shown that the method based on normalizing transformations by Tsuchiya and Konishi (1997) is efficient for the sample correlation coefficient in an elliptical sample.     

李白之创作与道士及上清经

李白深受道教的影响,前人虽然考虑到其歌词与道教或神仙思想之间的关系,但是没有指出过其直接的根据。从他的文学表现以及传记事实来看,可以说李白深受古上清经影响。他的道教背景又有一位叫做焦静真的女道士,而这位道士是司马承祯的后继者之一,也是唐玄宗妹妹玉真公主的师傅。这样一来,李白以及三个关键人物可以连系在一起从而解决关于李白入长安的问题。