Companion piece: Convention on the Rights of the Child special protection measures: overview of implications and value for children in the United States

The United Nations Convention on the Rights of the Child (CRC) is an international treaty that commits ratifying states parties to uphold the rights of all children under the age of 18. This article discusses the issues of highest relevance to the United States and reviews the pros and cons of ratifying, from the perspective of the convention's intent and potential, sovereignty of states, and national public policies, and regarding the special protection recommended for particularly vulnerable children. Specific implementation issues discussed include training, accountability, and monitoring.     

Locating social service centres using interactive graphics

The paper explores the feasibility of using interactive graphic based solution procedures in location problems with discrete choices. It compares solutions generated through interactive graphics with those generated through optimization for a problem context where service centres had to be located in rural India. The comparison demonstrates the feasibility of generating near optimal solutions for problems with a certain dimensionality. Broad features of the graphic software are described. The paper also highlights other advantages and limitations of the interactive graphic procedure.     

A model for national planning policies

This paper attempts to develop a multiobjective model to help policy-makers choose the most appropriate mix of economic policies concurrent with the elimination of serious gaps. Each individual policy attempts to achieve a specific goal or a set of subgoals; but it may hinder the achievement of some other subgoals. To differentiate between the importance of different objectives, the analyst assigns different priorities to each of the given set of subgoals. Three sets of results are provided by three separate computer runs of this model. Each set of results corresponds to one of the three priority structures, and each run indicates quite differing underachievements or over-achievements of individual subgoals. A detailed explanation for each of these deviations (gaps) from the targeted subgoals is attempted in an overall framework and some interactions between various gaps (savings gaps, foreign exchange gap, domestic growth gap, GNP gap, etc.) are also identified.     

Combination of Cancer Data in Quantitative Risk Assessments: Case Study Using Bromodichloromethane

There are often several data sets that may be used in developing a quantitative risk estimate for a carcinogen. These estimates are usually based, however, on the dose-response data for tumor incidences from a single sex/strain/species of animal. When appropriate, the use of more data should result in a higher level of confidence in the risk estimate. The decision to use more than one data set (e.g., representing different animal sexes, strains, species, or tumor sites) can be made following biological and statistical analyses of the compatibility of these data sets. Biological analysis involves consideration of factors such as the relevance of the animal models, study design and execution, dose selection and route of administration, the mechanism of action of the agent, its pharmacokinetics, any species- and/or sex-specific effects, and tumor site specificity. If the biological analysis does not prohibit combining data sets, statistical compatibility of the data sets is then investigated. A generalized likelihood ratio test is proposed for determining the compatibility of different data sets with respect to a common dose-response model, such as the linearized multistage model. The biological and statistical factors influencing the decision to combine data sets are described, followed by a case study of bromodichloromethane.     

Managing aging men in Asia: a strategic approach

We have established a comprehensive diagnostic paradigm for the management of aging men which seeks to evaluate the various determinants of the aging process in five major health areas: cardio-health, bone health, sex health, general health and endocrine state. This paradigm appears to be useful for the management of the problem of aging in our local population. It could be used for the management of individuals as well as for population research. When combined with the establishment of evidence-based management modalities, it will provide a useful tool for the holistic management of aging in Asia.