Confidence intervals for secondary parameters following a sequential test

In sequential studies, formal interim analyses are usually restricted to a consideration of a single null hypothesis concerning a single parameter of interest. Valid frequentist methods of hypothesis testing and of point and interval estimation for the primary parameter have already been devised for use at the end of such a study. However, the completed data set may warrant a more detailed analysis, involving the estimation of parameters corresponding to effects that were not used to determine when to stop, and yet correlated with those that were. This paper describes methods for setting confidence intervals for secondary parameters in a way which provides the correct coverage probability in repeated frequentist realizations of the sequential design used. The method assumes that information accumulates on the primary and secondary parameters at proportional rates. This requirement will be valid in many potential applications, but only in limited situations in survival analysis.     

Homosexuality,Religion, and the Family: The Effects of Religion on Americans’ Appraisals of the Parenting Abilities of Same-Sex Couples

Although a growing body of research focuses on Americans’ attitudes toward same-sex couples as parents, very few include measures of religion, and those that do fail to capture its multidimensional nature. Furthermore, many past studies relied on convenience samples of college students, or samples gathered outside the United States. Multivariate analyses of the 2012 General Social Survey—a nationally representative sample of adults in the United States—reveal that a slim majority of Americans still do not believe same-sex couples can parent as well as male-female couples, and the religious beliefs, behaviors, and affiliations of Americans are significantly and at times differentially associated with appraisals of same-sex couples’ parenting abilities. It appears that although religion is generally associated with more negative appraisals of the parenting abilities of same-sex couples, it is not uniformly so. Americans’ immediate religious and cultural context can shape their appraisals of homosexuality in diverse ways.     

A simple two-stage design for quantitative responses with application to a study in diabetic neuropathic pain

Two-stage designs offer substantial advantages for early phase II studies. The interim analysis following the first stage allows the study to be stopped for futility, or more positively, it might lead to early progression to the trials needed for late phase II and phase III. If the study is to continue to its second stage, then there is an opportunity for a revision of the total sample size. Two-stage designs have been implemented widely in oncology studies in which there is a single treatment arm and patient responses are binary. In this paper the case of two-arm comparative studies in which responses are quantitative is considered. This setting is common in therapeutic areas other than oncology. It will be assumed that observations are normally distributed, but that there is some doubt concerning their standard deviation, motivating the need for sample size review. The work reported has been motivated by a study in diabetic neuropathic pain, and the development of the design for that trial is described in detail.     

Implications of Ethnic Identity Exploration and Ethnic Identity Affirmation and Belonging for Intergroup Attitudes Among Adolescents

The present paper develops and tests two temporal models of the relationships among adolescents' ethnic identity exploration, ethnic identity affirmation and belonging, and attitudes toward their racial/ethnic ingroup and outgroups. Structural equation models for Euro‐Americans, Asian Americans, and Latinos revealed that all hypothesized relationships were positive and significant. The model in which ethnic identity exploration (at Time 1) predicts ethnic identity affirmation and belonging (at Time 2) was superior to the alternative model in which the relationship between them was reversed (i.e., affirmation and belonging at Time 1 predicts exploration at Time 2). Results (1) support the importance of exploration as a basis for establishing a secure attachment to one's ethnic identity, which, in turn, has positive implications for attitudes toward one's own group and other groups and (2) suggest that maintenance of ethnic identity is compatible with positive attitudes toward ethnic outgroups.     

"Lazy men", time-use,and rural development in Zambia

This paper examines how work and the labor in agriculture in rural sub-Saharan Africa is measured. Section 1 presents a historical example of colonial discourses of the "lazy" African (the Lamba in Zambia). Section 2 analyzes a study carried out in rural Zambia to illustrate the relationship between stereotypes held by many Europeans, particular aspects of the colonial project, and the social relations brought about by colonialism. Section 3 examines the ways in which present work and labor approaches in sub-Saharan Africa embody value judgements which leads to distorted documentation of the division of labor between opposite genders. Sections 4 through 7 look at a time-use study conducted in Zambia and argue that studies of such nature create value judgement on what comprises work, and about how researchers and planners classify this. Overall, this article has demonstrated that time-use surveys may provide inadequate understanding of women and men's work in the absence of an understanding of the local context in which the work is undertaken, and of labor markets.     

Bayesian adaptive dose‐escalation procedures for binary and continuous responses utilizing a gain function

One of the main aims of early phase clinical trials is to identify a safe dose with an indication of therapeutic benefit to administer to subjects in further studies. Ideally therefore, dose‐limiting events (DLEs) and responses indicative of efficacy should be considered in the dose‐escalation procedure. Several methods have been suggested for incorporating both DLEs and efficacy responses in early phase dose‐escalation trials. In this paper, we describe and evaluate a Bayesian adaptive approach based on one binary response (occurrence of a DLE) and one continuous response (a measure of potential efficacy) per subject. A logistic regression and a linear log‐log relationship are used respectively to model the binary DLEs and the continuous efficacy responses. A gain function concerning both the DLEs and efficacy responses is used to determine the dose to administer to the next cohort of subjects. Stopping rules are proposed to enable efficient decision making. Simulation results shows that our approach performs better than taking account of DLE responses alone. To assess the robustness of the approach, scenarios where the efficacy responses of subjects are generated from an E _max model, but modelled by the linear log–log model are also considered. This evaluation shows that the simpler log–log model leads to robust recommendations even under this model showing that it is a useful approximation to the difficulty in estimating E _max model. Additionally, we find comparable performance to alternative approaches using efficacy and safety for dose‐finding. Copyright © 2015 John Wiley & Sons, Ltd.     

A still,small voice: Letter‐writing,testimony and the project of address in Etty Hillesum's letters from Westerbork

Abstract

This paper derives from an exploration of the ways in which the letters of Holocaust writer Etty Hillesum, which are seemingly resistant to many of the interests of current trauma theory, can be read in relation to contemporary writing on testimonial. In particular, the three theorists I shall discuss here, Derrida, Caruth and Irigaray, directly address Freud's Beyond the Pleasure Principle, a central text in the current refiguring of trauma. This paper traces the ways in which Hillesum's letters can be read across the theoretical accounts. An interpretation of Hillesum's writing emerges in which the conventional emphasis on the mystical aspect of her texts is reinterpreted in terms of Caruth's emphasis on the life drive. Viewed as forging a creative language of departure, Hillesum's letters are situated in a central relation to the most recent developments in the theoretical discourse around testimony.     

Sacred Rites and Civil Rights: Religion's Effect on Attitudes Toward Same‐Sex Unions and the Perceived Cause of Homosexuality*

Objective. Past research reveals how religion and opinions about the cause of homosexuality influence attitudes concerning same‐sex unions. No study to date contains a comprehensive collection of religion measures while also accounting for views of the cause of homosexuality. Therefore, this study investigates the extent to which religion predicts certain attribution beliefs as well as attitudes toward same‐sex unions while controlling for attribution beliefs. Method. The Baylor Religion Survey (2007 ) is used to estimate binary logistic models predicting the effects of religion and attribution beliefs on attitudes toward same‐sex unions. Findings. First, religion is strongly associated with the belief that homosexuals choose their sexual orientation. Second, religion maintains a significant association with attitudes toward same‐sex unions despite inclusion of an attribution variable. Conclusion. Even if a biological explanation for homosexuality is ultimately proven, unfavorable attitudes toward same‐sex unions will most likely endure due to religion's persistent effect.     

Masculinity: Shutting Out the Nasty Bits

Books reviewed in this article: John MacInnes, The End of Masculinity Lee H. Bowker (ed.), Masculinities and Violence caroline Sweetman (ed.), Men and Masculinity     

Physical and mental health changes in aging foster parents: Do child behavioural problems hasten declines?

This study examined foster parent physical and mental health over time. It was hypothesized that increased severity and frequency of child behavioural problems, whether externalizing or internalizing, would be associated with poorer health over time, especially for foster parents ≥60 years of age. Data from the baseline and Wave 2 interview of the 2010 National Survey of Child and Adolescent Well‐Being were used. The final analytic sample included kin and nonkin foster parents who had custody of a foster child for both waves of data collection (n = 962). Ordinary Least Squares regression models with lagged dependent variables showed that foster parents ≥60 had deteriorating physical health over time, but caregiver age alone had no association with worsening mental health. However, parents ≥60 caring for children with externalizing behavioural problems had significantly improved physical health. Mental health of parents ≥60 significantly diminished if child externalizing or internalizing problems worsened. Findings indicate that for aging foster parents, externalizing child behaviours may stimulate physical activity and improved physical health, yet any type of child behavioural problem can deteriorate mental health functioning.