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We develop methodology for a multistage-decision problem with flexible number of stages in which the rewards are survival times that are subject to censoring. We present a novel Q-learning algorithm that is adjusted for censored data and allows a flexible number of stages. We provide finite sample bounds on the generalization error of the policy learned by the algorithm, and show that when the optimal Q-function belongs to the approximation space, the expected survival time for policies obtained by the algorithm converges to that of the optimal policy. We simulate a multistage clinical trial with flexible number of stages and apply the proposed censored-Q-learning algorithm to find individualized treatment regimens. The methodology presented in this paper has implications in the design of personalized medicine trials in cancer and in other life-threatening diseases.  相似文献   
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Prior studies in the sociology of accidents have shown that different social groups have different rates of accident involvement. This study extends those studies by implementing Bourdieu's relational perspective of social space to systematically explore the homology between drivers’ social characteristics and their involvement in specific types of motor vehicle accident. Using a large database that merges official Israeli road‐accident records with socioeconomic data from two censuses, this research maps the social order of road accidents through multiple correspondence analysis. Extending prior studies, the results show that different social groups indeed tend to be involved in motor vehicle accidents of different types and severity. For example, we find that drivers from low socioeconomic backgrounds are overinvolved in severe accidents with fatal outcomes. The new findings reported here shed light on the social regularity of road accidents and expose new facets in the social organization of death.  相似文献   
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N Levi 《Child welfare》1975,54(5):309-317
A new approach to social services, including services to children, is being taken by the government of the New Democratic Party that assumed office in British Columbia in 1972.  相似文献   
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The purpose of this paper is to develop a general framework for supply contracts in which portfolios of contracts can be analyzed and optimized. We focus on a multi‐period environment with convex contract, spot market, and inventory holding costs. We specialize the model to the case of a portfolio consisting of option contracts. We characterize the optimal replenishment policy and show that it has a simple structure. Namely, the use of every different option contract and the spot market is dictated by a modified base‐stock policy. In addition, we derive conditions to determine when an option is relatively attractive compared to other options or the spot market. Finally, we present our computational study, where we report the sensitivity of the results to the parameters of the model. Our experiments indicate that portfolio contracts not only increase the manufacturer's expected profit, but can also reduce its financial risk.  相似文献   
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Gad Yair 《Social Identities》2013,19(4-5):346-362
The present paper extends recent studies of national character – suggesting that the Israeli case revolves around a set of deep cultural codes which constitute various empirical manifestations. Broadening on this re-emerging paradigm, the study provides a specific case study of a major trait of Israeli national character, namely existential anxiety and fear of annihilation. It does so while advancing the idea that cultural trauma sets a context for Israeli national character. The analysis shows that Israelis constantly reference persistent and endemic existential fears of annihilation. They do so while tying together four levels: the mythological predicament, historical evidence, contemporary threats and future risks.  相似文献   
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