Admissible treatment rules for a risk-averse planner with experimental data on an innovation

Consider a planner choosing treatments for observationally identical persons who vary in their response to treatment. There are two treatments with binary outcomes. One is a status quo with known population success rate. The other is an innovation for which the data are the outcomes of an experiment. Karlin and Rubin [1956. The theory of decision procedures for distributions with monotone likelihood ratio. Ann. Math. Statist. 27, 272–299] assumed that the objective is to maximize the population success rate and showed that the admissible rules are the KR-monotone   rules. These assign everyone to the status quo if the number of experimental successes is below a specified threshold and everyone to the innovation if experimental success exceeds the threshold. We assume that the objective is to maximize a concave-monotone function f(·)$f(·)$ of the success rate and show that admissibility depends on the curvature of f(·)$f(·)$. Let a fractional monotone   rule be one where the fraction of persons assigned to the innovation weakly increases with the number of experimental successes. We show that the class of fractional monotone rules is complete if f(·)$f(·)$ is concave and strictly monotone. Define an M-step monotone rule   to be a fractional monotone rule with an interior fractional treatment assignment for no more than M$M$ consecutive values of the number of experimental successes. The M$M$-step monotone rules form a complete class if f(·)$f(·)$ is differentiable and has sufficiently weak curvature. Bayes rules and the minimax-regret rule depend on the curvature of the welfare function.     

Bayesian model selection for D‐vine pair‐copula constructions

In recent years analyses of dependence structures using copulas have become more popular than the standard correlation analysis. Starting from Aas et al. ( 2009 ) regular vine pair‐copula constructions (PCCs) are considered the most flexible class of multivariate copulas. PCCs are involved objects but (conditional) independence present in data can simplify and reduce them significantly. In this paper the authors detect (conditional) independence in a particular vine PCC model based on bivariate t copulas by deriving and implementing a reversible jump Markov chain Monte Carlo algorithm. However, the methodology is general and can be extended to any regular vine PCC and to all known bivariate copula families. The proposed approach considers model selection and estimation problems for PCCs simultaneously. The effectiveness of the developed algorithm is shown in simulations and its usefulness is illustrated in two real data applications. The Canadian Journal of Statistics 39: 239–258; 2011 © 2011 Statistical Society of Canada     

Leader motive profiles in eight types of organizations

McClelland (1975) introduced the leadership motive pattern (LMP), a motivational configuration found to contribute to leader performance in traditional bureaucratic organizations. Using McClelland's general theory of motivation and Miner's work on organizational sociology, we refine McClelland's original leadership motive pattern, develop leader motive profiles for eight classical and new types of organizations, and advance eight testable propositions for empirical verification. We conclude with implications for future research and practice.     

Trial Size for Near-Optimal Choice Between Surveillance and Aggressive Treatment: Reconsidering MSLT-II

Abstract

A convention in designing randomized clinical trials has been to choose sample sizes that yield specified statistical power when testing hypotheses about treatment response. Manski and Tetenov recently critiqued this convention and proposed enrollment of sufficiently many subjects to enable near-optimal treatment choices. This article develops a refined version of that analysis applicable to trials comparing aggressive treatment of patients with surveillance. The need for a refined analysis arises because the earlier work assumed that there is only a primary health outcome of interest, without secondary outcomes. An important aspect of choice between surveillance and aggressive treatment is that the latter may have side effects. One should then consider how the primary outcome and side effects jointly determine patient welfare. This requires new analysis of sample design. As a case study, we reconsider a trial comparing nodal observation and lymph node dissection when treating patients with cutaneous melanoma. Using a statistical power calculation, the investigators assigned 971 patients to dissection and 968 to observation. We conclude that assigning 244 patients to each option would yield findings that enable suitably near-optimal treatment choice. Thus, a much smaller sample size would have sufficed to inform clinical practice.     

Sequencing of emphases on technology alliances and internal R&D: The effects of the market cycle

How does the market reward technological firms' emphases on alliancing and R&D strategies depending on the phase in the market cycle? I use the 1990s’ “dot-com bubble” cycle and its burst after 2000 to look for joint effects of technology alliances and internal R&D investments on firm market valuations. I show that the existing theory is incomplete without considering (1) the temporal sequencing of emphases on technology alliances and R&D, and (2) the phase in the market cycle. I show that different phases of the market cycle reward different temporal sequences of emphases on technology alliances and internal R&D. This paper contributes to the theory of complementarity of alliances and R&D by pointing out previously unexplored factors that make technology alliances and R&D investments either complements or substitutes.