A new long-term survival model with dispersion induced by discrete frailty

Lifetime Data Analysis - Frailty models are generally used to model heterogeneity between the individuals. The distribution of the frailty variable is often assumed to be continuous. However, there...     

A model with long-term survivors: negative binomial Birnbaum-Saunders

Abstract

We propose a cure rate survival model by assuming that the number of competing causes of the event of interest follows the negative binomial distribution and the time to the event of interest has the Birnbaum-Saunders distribution. Further, the new model includes as special cases some well-known cure rate models published recently. We consider a frequentist analysis for parameter estimation of the negative binomial Birnbaum-Saunders model with cure rate. Then, we derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes. We illustrate the usefulness of the proposed model in the analysis of a real data set from the medical area.     

Unified multivariate survival model with a surviving fraction: an application to a Brazilian customer churn data

In this paper we propose a new lifetime model for multivariate survival data in presence of surviving fractions and examine some of its properties. Its genesis is based on situations in which there are m types of unobservable competing causes, where each cause is related to a time of occurrence of an event of interest. Our model is a multivariate extension of the univariate survival cure rate model proposed by Rodrigues et al. [37 J. Rodrigues, V.G. Cancho, M. de Castro, and F. Louzada-Neto, On the unification of long-term survival models, Statist. Probab. Lett. 79 (2009), pp. 753–759. doi: 10.1016/j.spl.2008.10.029[Crossref], [Web of Science ®] , [Google Scholar]]. The inferential approach exploits the maximum likelihood tools. We perform a simulation study in order to verify the asymptotic properties of the maximum likelihood estimators. The simulation study also focus on size and power of the likelihood ratio test. The methodology is illustrated on a real data set on customer churn data.     

Influence diagnostics for the Weibull-Negative-Binomial regression model with cure rate under latent failure causes

In this paper, we propose a flexible cure rate survival model by assuming that the number of competing causes of the event of interest follows the Negative Binomial distribution and the time to event follows a Weibull distribution. Indeed, we introduce the Weibull-Negative-Binomial (WNB) distribution, which can be used in order to model survival data when the hazard rate function is increasing, decreasing and some non-monotonous shaped. Another advantage of the proposed model is that it has some distributions commonly used in lifetime analysis as particular cases. Moreover, the proposed model includes as special cases some of the well-know cure rate models discussed in the literature. We consider a frequentist analysis for parameter estimation of a WNB model with cure rate. Then, we derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to perform global influence analysis. Finally, the methodology is illustrated on a medical data.     

A general long-term aging model with different underlying activation mechanisms: Modeling,Bayesian estimation,and case influence diagnostics

In this paper we propose a general cure rate aging model. Our approach enables different underlying activation mechanisms which lead to the event of interest. The number of competing causes of the event of interest is assumed to follow a logarithmic distribution. The model is parameterized in terms of the cured fraction which is then linked to covariates. We explore the use of Markov chain Monte Carlo methods to develop a Bayesian analysis for the proposed model. Moreover, some discussions on the model selection to compare the fitted models are given, as well as case deletion influence diagnostics are developed for the joint posterior distribution based on the ψ-divergence, which has several divergence measures as particular cases, such as the Kullback–Leibler (K-L), J-distance, L₁ norm, and χ²-square divergence measures. Simulation studies are performed and experimental results are illustrated based on a real malignant melanoma data.     

The exponential Poisson logarithmic distribution

Abstract

In this article, we proposed a new three parameter lifetime distribution motivated mainly by lifetime issues, which generalizes the Exponential Poisson distribution proposed by Cancho et al. (2011) Cancho, V.G., Louzada-Neto, F., Barriga, G.D. (2011). The poisson-exponential lifetime distribution. Computat. Statist. Data Anal. 55:677–686.[Crossref], [Web of Science ®] , [Google Scholar]. We derive various standard mathematical properties of the proposed model including a formal proof of its probability density function and hazard rate function. The inference via the maximum likelihood approach is discussed. The performance of the maximum likelihood estimators, the likelihood ratio test and its power are studied by simulation. Finally, the proposed model is fitted to two real data sets and it is compared with several models.     

On estimation and diagnostics analysis in log-generalized gamma regression model for interval-censored data

The interval-censored survival data appear very frequently, where the event of interest is not observed exactly but it is only known to occur within some time interval. In this paper, we propose a location-scale regression model based on the log-generalized gamma distribution for modelling interval-censored data. We shall be concerned only with parametric forms. The proposed model for interval-censored data represents a parametric family of models that has, as special submodels, other regression models which are broadly used in lifetime data analysis. Assuming interval-censored data, we consider a frequentist analysis, a Jackknife estimator and a non-parametric bootstrap for the model parameters. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some techniques to perform global influence.     

Log-Weibull extended regression model: Estimation,sensitivity and residual analysis

The failure rate function commonly has a bathtub shape in practice. In this paper we discuss a regression model considering new Weibull extended distribution developed by Xie et al. (2002) that can be used to model this type of failure rate function. Assuming censored data, we discuss parameter estimation: maximum likelihood method and a Bayesian approach where Gibbs algorithms along with Metropolis steps are used to obtain the posterior summaries of interest. We derive the appropriate matrices for assessing the local influence on the parameter estimates under different perturbation schemes, and we also present some ways to perform global influence. Also, some discussions on case deletion influence diagnostics are developed for the joint posterior distribution based on the Kullback–Leibler divergence. Besides, for different parameter settings, sample sizes and censoring percentages, are performed various simulations and display and compare the empirical distribution of the Martingale-type residual with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be straightforwardly extended to the martingale-type residual in log-Weibull extended models with censored data. Finally, we analyze a real data set under a log-Weibull extended regression model. We perform diagnostic analysis and model check based on the martingale-type residual to select an appropriate model.     

Scale mixtures log-Birnbaum–Saunders regression models with censored data: a Bayesian approach

The main objective of this paper is to develop a full Bayesian analysis for the Birnbaum–Saunders (BS) regression model based on scale mixtures of the normal (SMN) distribution with right-censored survival data. The BS distributions based on SMN models are a very general approach for analysing lifetime data, which has as special cases the Student-t-BS, slash-BS and the contaminated normal-BS distributions, being a flexible alternative to the use of the corresponding BS distribution or any other well-known compatible model, such as the log-normal distribution. A Gibbs sample algorithm with Metropolis–Hastings algorithm is used to obtain the Bayesian estimates of the parameters. Moreover, some discussions on the model selection to compare the fitted models are given and case-deletion influence diagnostics are developed for the joint posterior distribution based on the Kullback–Leibler divergence. The newly developed procedures are illustrated on a real data set previously analysed under BS regression models.     

Generalized log-gamma regression models with cure fraction

In this paper, the generalized log-gamma regression model is modified to allow the possibility that long-term survivors may be present in the data. This modification leads to a generalized log-gamma regression model with a cure rate, encompassing, as special cases, the log-exponential, log-Weibull and log-normal regression models with a cure rate typically used to model such data. The models attempt to simultaneously estimate the effects of explanatory variables on the timing acceleration/deceleration of a given event and the surviving fraction, that is, the proportion of the population for which the event never occurs. The normal curvatures of local influence are derived under some usual perturbation schemes and two martingale-type residuals are proposed to assess departures from the generalized log-gamma error assumption as well as to detect outlying observations. Finally, a data set from the medical area is analyzed.