川东北地区须家河组二段储层差异性分析

随着勘探程度的深入，为了扩大四川盆地天然气勘探领域、寻找新的勘探接替区，四川盆地的勘探区域由盆内逐渐向盆缘延伸。在这种背景下，川东北地区须家河组二段相继取得新的勘探成果，但在勘探开发过程中逐渐暴露了诸如区块之间气井产能差异大，储层的碎屑组分、结构及厚度、物性、孔隙结构差异明显等问题，制约了勘探开发的步伐。针对上述问题，根据岩芯观察描述、分析化验资料及测井解释成果，从沉积、成岩方面入手，对比剖析了川东北龙岗和营山地区须二段储层特征的差异性及其成因，认为远离物源区和高能水体的反复淘洗是造成储层差异性的首要因素，强烈的压实作用和多期石英加大对储层差异性起关键作用，自生绿泥石衬边胶结和长石选择性溶蚀最终决定了储层差异性。从而解释了气藏勘探开发中遇到的诸多问题，对有效指导该区的下一步勘探开发工作具有重要意义。     

Inference and Decision Making for 21st-Century Drug Development and Approval

ABSTRACT

The cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making.     

Ethical Numbers: Ethics Training in U.S. Graduate Statistics Programs, 2013–2014

As important members of research teams, statisticians bear an ethical responsibility to analyze, interpret, and report data honestly and objectively. One way of reinforcing ethical responsibilities is through required courses covering a variety of ethics-related topics at the graduate level. We assessed ethics requirements for graduate-level statistics training programs in the United States for the 2013–2014 academic year using the websites of 88 universities, examining 103 biostatistics programs, and 136 statistics degree programs. We categorized programs’ ethics training requirements as required or not required. Thirty-one (35.1%) universities required an ethics course for at least some degree students. Sixty-two (25.5%) degree programs required an ethics course for at least some students. The majority (77.4%) of required courses were worth 0 or 1 credit. Of the 177 programs without an ethics requirement, 19 (10.7%) listed an ethics elective. Although a single ethics course is insufficient for instilling an ethical approach to science, degree programs that model expectations through coursework point to the value of ethics in science. More training programs should prepare statisticians to consider the ethical dimensions of their work through required coursework. Supplementary materials for this article are available online.     

Foreign-born and native-born migration in the U.S.: evidence from linked IRS administrative and census survey records

Journal of Population Research - This paper details efforts to link administrative records from the Internal Revenue Service (IRS) to American Community Survey (ACS) and 2010 Census microdata for...     

四川省小城镇建设中的几个问题

从费孝通先生研究"小城镇、大问题"到江泽民总书记提出"小城镇、大战略",加强小城镇发展建设已成为党中央在新世纪推进中国城市化的重大决策之一.     

足球运动员训练负荷的生化指标监测

通过对足球运动员实施不同训练负荷方案后心率、血乳酸、血尿素氮的检测与分析研究 ,发现该三项指标随运动负荷强度的增加而增加。因此采用血乳酸、血尿素氮不仅能够客观评定足球训练和比赛的运动负荷强度 ,而且也是控制运动负荷强度以及促进运动疲劳恢复的有效监测指标 ,其方法简单易行 ,从而为教练员加强医务监督、合理安排训练负荷提供科学理论依据。     

多媒体教学方法的探讨

本文通过对传统的板书教学与多媒体教学方法的比较 ,分析了它们的优缺点 ,进而介绍了多媒体教学课件的制作方法 ,探讨了如何运用多媒体教学手段组织教学。     

谈新时期图书馆员的继续教育

从分析太原理工大学图书馆人员现状入手 ,结合国内外图书馆员继续教育发展状况 ,提出图书馆开展继续教育的具体措施 :进行在职教育和在职培训     

一种基于宏块类型的自适应运动估计算法

利用低码流、运动量较小的视频序列前后帧具有很强的时空相关性的特点，进行了算法改进的实验，在保持视频性能的同时，减少了运动搜索的计算量，提高了运动估计的速度。     

冲激噪声环境中LFM信号的特征参数估计

SαS稳定分布是一类非常重要的非高斯随机分布,具有这类分布的噪声称为冲激噪声。在冲激噪声情况下,α阶以上的矩均不存在,导致基于二阶矩的高斯模型算法性能下降,甚至不能正常工作。该文提出了一种在冲激噪声环境下线性调频信号特征参数估计的算法,通过分析冲激噪声的具体特点,给出了修正的低阶矩模糊函数,并结合Radon变换估计了冲激噪声环境下LFM信号的参数。该算法既可应用于冲激噪声下,又可应用于高斯噪声环境,故具有较好的鲁棒性。最后用计算机仿真验证了该算法的有效性。