Estimating the grid of time-points for the piecewise exponential model

One of the greatest challenges related to the use of piecewise exponential models (PEMs) is to find an adequate grid of time-points needed in its construction. In general, the number of intervals in such a grid and the position of their endpoints are ad-hoc choices. We extend previous works by introducing a full Bayesian approach for the piecewise exponential model in which the grid of time-points (and, consequently, the endpoints and the number of intervals) is random. We estimate the failure rates using the proposed procedure and compare the results with the non-parametric piecewise exponential estimates. Estimates for the survival function using the most probable partition are compared with the Kaplan-Meier estimators (KMEs). A sensitivity analysis for the proposed model is provided considering different prior specifications for the failure rates and for the grid. We also evaluate the effect of different percentage of censoring observations in the estimates. An application to a real data set is also provided. We notice that the posteriors are strongly influenced by prior specifications, mainly for the failure rates parameters. Thus, the priors must be fairly built, say, really disclosing the expert prior opinion.     

A class of dynamic piecewise exponential models with random time grid

A novel fully Bayesian approach for modeling survival data with explanatory variables using the Piecewise Exponential Model (PEM) with random time grid is proposed. We consider a class of correlated Gamma prior distributions for the failure rates. Such prior specification is obtained via the dynamic generalized modeling approach jointly with a random time grid for the PEM. A product distribution is considered for modeling the prior uncertainty about the random time grid, turning possible the use of the structure of the Product Partition Model (PPM) to handle the problem. A unifying notation for the construction of the likelihood function of the PEM, suitable for both static and dynamic modeling approaches, is considered. Procedures to evaluate the performance of the proposed model are provided. Two case studies are presented in order to exemplify the methodology. For comparison purposes, the data sets are also fitted using the dynamic model with fixed time grid established in the literature. The results show the superiority of the proposed model.