Simultaneous estimation for semi-parametric multi-index models

Estimation of a general multi-index model comprises determining the number of linear combinations of predictors (structural dimension) that are related to the response, estimating the loadings of each index vector, selecting the active predictors and estimating the underlying link function. These objectives are often achieved sequentially at different stages of the estimation process. In this study, we propose a unified estimation approach under a semi-parametric model framework to attain these estimation goals simultaneously. The proposed estimation method is more efficient and stable than many existing methods where the estimation error in the structural dimension may propagate to the estimation of the index vectors and variable selection stages. A detailed algorithm is provided to implement the proposed method. Comprehensive simulations and a real data analysis illustrate the effectiveness of the proposed method.     

Random sliced inverse regression

Sliced Inverse Regression (SIR; 1991) is a dimension reduction method for reducing the dimension of the predictors without losing regression information. The implementation of SIR requires inverting the covariance matrix of the predictors—which has hindered its use to analyze high-dimensional data where the number of predictors exceed the sample size. We propose random sliced inverse regression (rSIR) by applying SIR to many bootstrap samples, each using a subset of randomly selected candidate predictors. The final rSIR estimate is obtained by aggregating these estimates. A simple variable selection procedure is also proposed using these bootstrap estimates. The performance of the proposed estimates is studied via extensive simulation. Application to a dataset concerning myocardial perfusion diagnosis from cardiac Single Proton Emission Computed Tomography (SPECT) images is presented.