A parallel analysis of individual and ecological data on residential radon and lung cancer in south-west England

Parallel individual and ecological analyses of data on residential radon have been performed using information on cases of lung cancer and population controls from a recent study in south-west England. For the individual analysis the overall results indicated that the relative risk of lung cancer at 100 Bq m⁻³ compared with at 0 Bq m⁻³ was 1.12 (95% confidence interval (0.99, 1.27)) after adjusting for age, sex, smoking, county of residence and social class. In the ecological analysis substantial bias in the estimated effect of radon was present for one of the two counties involved unless an additional variable, urban–rural status, was included in the model, although this variable was not an important confounder in the individual level analysis. Most of the methods that have been recommended for overcoming the limitations of ecological studies would not in practice have proved useful in identifying this variable as an appreciable source of bias.     

Regression models for analyzing clustered binary and continuous outcomes under an assumption of exchangeability

Scientific experiments commonly result in clustered discrete and continuous data. Existing methods for analyzing such data include the use of quasi-likelihood procedures and generalized estimating equations to estimate marginal mean response parameters. In applications to areas such as developmental toxicity studies, where discrete and continuous measurements are recorded on each fetus, or clinical ophthalmologic trials, where different types of observations are made on each eye, the assumption that data within cluster are exchangeable is often very reasonable. We use this assumption to formulate fully parametric regression models for clusters of bivariate data with binary and continuous components. The regression models proposed have marginal interpretations and reproducible model structures. Tractable expressions for likelihood equations are derived and iterative schemes are given for computing efficient estimates (MLEs) of the marginal mean, correlations, variances and higher moments. We demonstrate the use the ‘exchangeable’ procedure with an application to a developmental toxicity study involving fetal weight and malformation data.     

Imputation by power transformation

In this paper, a new power transformation estimator of population mean in the presence of non-response has been suggested. The estimator of mean obtained from proposed technique remains better than the estimators obtained from ratio or mean methods of imputation. The mean squared error of the resultant estimator is less than that of the estimator obtained on the basis of ratio method of imputation for the optinum choice of parameters. An estimator for estimating a parameter involved in the process of new method of imputation has been discussed. The MSE expressions for the proposed estimators have been derived analytically and compared empirically. Product method of imputation for negatively correlated variables has also been introduced. The work has been extended to the case of multi-auxiliary information to be used for imputation.     

A class of robust stepwise alternatives to Hotelling's T 2 tests

Hotelling's T 2 test is known to be optimal under multivariate normality and is reasonably validity-robust when the assumption fails. However, some recently introduced robust test procedures have superior power properties and reasonable type I error control with non-normal populations. These, including the tests due to Tiku & Singh (1982), Tiku & Balakrishnan (1988) and Mudholkar & Srivastava (1999b, c), are asymptotically valid but are useful with moderate size samples only if the population dimension is small. A class of B-optimal modifications of the stepwise alternatives to Hotellings T 2 introduced by Mudholkar & Subbaiah (1980) are simple to implement and essentially equivalent to the T 2 test even with small samples. In this paper we construct and study the robust versions of these modified stepwise tests using trimmed means instead of sample means. We use the robust one- and two-sample trimmed- t procedures as in Mudholkar et al. (1991) and propose statistics based on combining them. The results of an extensive Monte Carlo experiment show that the robust alternatives provide excellent type I error control and a substantial gain in power.     

On a random series in a hilbert space

Let (S_n) be partial sums of a non-degenerate sequence of Identically and independently distributed random variables taking values in a separable Hilbert space. Then for 0 ≤ β ≤ 3/2, the series converges almost nowhere. For β > 3/2 this may not be true.     

Regression analysis of multivariate recurrent event data with a dependent terminal event

Recurrent event data occur in many clinical and observational studies (Cook and Lawless, Analysis of recurrent event data, 2007) and in these situations, there may exist a terminal event such as death that is related to the recurrent event of interest (Ghosh and Lin, Biometrics 56:554–562, 2000; Wang et al., J Am Stat Assoc 96:1057–1065, 2001; Huang and Wang, J Am Stat Assoc 99:1153–1165, 2004; Ye et al., Biometrics 63:78–87, 2007). In addition, sometimes there may exist more than one type of recurrent events, that is, one faces multivariate recurrent event data with some dependent terminal event (Chen and Cook, Biostatistics 5:129–143, 2004). It is apparent that for the analysis of such data, one has to take into account the dependence both among different types of recurrent events and between the recurrent and terminal events. In this paper, we propose a joint modeling approach for regression analysis of the data and both finite and asymptotic properties of the resulting estimates of unknown parameters are established. The methodology is applied to a set of bivariate recurrent event data arising from a study of leukemia patients.     

Maximum likelihood estimation for the proportional odds model with mixed interval-censored failure time data

This article discusses regression analysis of mixed interval-censored failure time data. Such data frequently occur across a variety of settings, including clinical trials, epidemiologic investigations, and many other biomedical studies with a follow-up component. For example, mixed failure times are commonly found in the two largest studies of long-term survivorship after childhood cancer, the datasets that motivated this work. However, most existing methods for failure time data consider only right-censored or only interval-censored failure times, not the more general case where times may be mixed. Additionally, among regression models developed for mixed interval-censored failure times, the proportional hazards formulation is generally assumed. It is well-known that the proportional hazards model may be inappropriate in certain situations, and alternatives are needed to analyze mixed failure time data in such cases. To fill this need, we develop a maximum likelihood estimation procedure for the proportional odds regression model with mixed interval-censored data. We show that the resulting estimators are consistent and asymptotically Gaussian. An extensive simulation study is performed to assess the finite-sample properties of the method, and this investigation indicates that the proposed method works well for many practical situations. We then apply our approach to examine the impact of age at cranial radiation therapy on risk of growth hormone deficiency in long-term survivors of childhood cancer.