Income earning opportunity and work performance affect donating behavior: Evidence from dictator game experiments

Using dictator game experiments, the authors investigate the effect on donation of the dictator and/or recipient working prior to the dictator donating. We focus on two issues that previous studies have not considered. First, we examine the impact on donating behavior of a difference in endowment caused by the dictator's work performance. Second, we explore donation behavior when the recipient's work does not yield income or affect the dictator's endowment, but the recipient's work performance is made known to the dictator. Experimental results indicate that donating behavior is affected not only by the dictator working, but also by the recipient working. In addition, donating behavior is affected by income level, as determined by the dictator's work performance, and is influenced by the recipient's work performance, two findings not previously reported.     

Novel concentration-QTc models for early clinical studies with parallel placebo controls: A simulation study

The QTc interval of the electrocardiogram is a pharmacodynamic biomarker for drug-induced cardiac toxicity. The ICH E14 guideline Questions and Answers offer a solution for evaluating a concentration-QTc relationship in early clinical studies as an alternative to conducting a thorough QT/QTc study. We focused on covariance structures of QTc intervals on the baseline day and dosing day (two-day covariance structure,) and proposed a two-day QTc model to analyze a concentration-QTc relationship for placebo-controlled parallel phase 1 single ascending dose studies. The proposed two-day QTc model is based on a constrained longitudinal data analysis model and a mixed effects model, thus allowing various variance components to capture the two-day covariance structure. We also propose a one-day QTc model for the situation where no baseline day or only a pre-dose baseline is available and models for multiple ascending dose studies where concentration and QTc intervals are available over multiple days. A simulation study shows that the proposed models control the false negative rate for positive drugs and have both higher accuracy and power for negative drugs than existing models in a variety of settings for the two-day covariance structure. The proposed models will promote early and accurate evaluation of the cardiac safety of new drugs.