Accent on Teaching Materials

This department includes the two sections New Developments in Statistical Computing and Statistical Computing Software Reviews; suitable contents for each of these sections are described under the respective section heading. Articles submitted for the department, outside the two sections, should not be highly technical and should be relevant to the teaching or practice of statistical computing.

An unbiased estimator of e is used to motivate a simple simulation exercise that requires only observations from the distribution uniform on (0, 1). Antithetic variables are introduced and applied to the simulation problem to give a second unbiased estimator of e with reduced variance.     

Simple heterogeneity variance estimation for meta-analysis

Summary.  A simple method of estimating the heterogeneity variance in a random-effects model for meta-analysis is proposed. The estimator that is presented is simple and easy to calculate and has improved bias compared with the most common estimator used in random-effects meta-analysis, particularly when the heterogeneity variance is moderate to large. In addition, it always yields a non-negative estimate of the heterogeneity variance, unlike some existing estimators. We find that random-effects inference about the overall effect based on this heterogeneity variance estimator is more reliable than inference using the common estimator, in terms of coverage probability for an interval estimate.     

Sample size determination in fixed‐dose combination drug studies

In this paper, the application of the intersection–union test method in fixed‐dose combination drug studies is discussed. An approximate sample size formula for the problem of testing the efficacy of a combination drug using intersection–union tests is proposed. The sample sizes obtained from the formula are found to be reasonably accurate in terms of attaining the target power 1?β for a specified β. Copyright © 2003 John Wiley & Sons, Ltd.