Particle swarm optimization based Liu-type estimator

In this study, a new method for the estimation of the shrinkage and biasing parameters of Liu-type estimator is proposed. Because k is kept constant and d is optimized in Liu’s method, a (k, d) pair is not guaranteed to be the optimal point in terms of the mean square error of the parameters. The optimum (k, d) pair that minimizes the mean square error, which is a function of the parameters k and d, should be estimated through a simultaneous optimization process rather than through a two-stage process. In this study, by utilizing a different objective function, the parameters k and d are optimized simultaneously with the particle swarm optimization technique.     

Alternative modeling techniques for the quantal response data in mixture experiments

Mixture experiments are commonly encountered in many fields including chemical, pharmaceutical and consumer product industries. Due to their wide applications, mixture experiments, a special study of response surface methodology, have been given greater attention in both model building and determination of designs compared with other experimental studies. In this paper, some new approaches are suggested on model building and selection for the analysis of the data in mixture experiments by using a special generalized linear models, logistic regression model, proposed by Chen et al. [7]. Generally, the special mixture models, which do not have a constant term, are highly affected by collinearity in modeling the mixture experiments. For this reason, in order to alleviate the undesired effects of collinearity in the analysis of mixture experiments with logistic regression, a new mixture model is defined with an alternative ratio variable. The deviance analysis table is given for standard mixture polynomial models defined by transformations and special mixture models used as linear predictors. The effects of components on the response in the restricted experimental region are given by using an alternative representation of Cox's direction approach. In addition, odds ratio and the confidence intervals of odds ratio are identified according to the chosen reference and control groups. To compare the suggested models, some model selection criteria, graphical odds ratio and the confidence intervals of the odds ratio are used. The advantage of the suggested approaches is illustrated on tumor incidence data set.     

Confidence bands for the Michaelis-Menten kinetic model

The maximization and minimization procedure for constructing confidence bands for the general nonlinear regression model is explained. Then, using the maximization and minimization procedure, a conservative confidence band for the Michaelis-Menten kinetic model used in enzyme kinetics is constructed.